Aspirin, non-steroidal anti-inflammatory drug and paracetamol use is associated with an increased risk of prostate cancer in a large, population-based, case-control study
Session type: Poster sessions
1University of Bristol, UK, 2John Radcliffe Hospital, Oxford, UK, 3University of Cambridge, UK
Evidence from laboratory studies suggests that chronic inflammation plays an important role in prostate cancer aetiology. This has resulted in speculation that non-steroidal anti-inflammatory drugs, such as aspirin and ibuprofen, may protect against prostate cancer development.
We used data from a case-control study (ncases= 1,016; ncontrols= 5,043), nested within a UK-wide population-based study that used a PSA-testing approach, to investigate the effect of aspirin, non-steroidal anti-inflammatory drug and paracetamol use on prostate cancer risk.
We found evidence for an increased risk of PSA-detected prostate cancer amongst users of aspirin (OR= 1.24, 95% CI= 1.01 to 1.52), non-aspirin non-steroidal anti-inflammatory drugs (OR= 1.51, 95% CI= 1.13 to 2.01) and overall non-steroidal anti-inflammatory drugs (OR= 1.37, 95% CI= 1.14 to 1.64). Paracetamol use was not associated with prostate cancer. Aspirin, non-steroidal anti-inflammatory drug and paracetamol use were associated with reduced serum PSA concentrations amongst controls.
Our findings raise doubts about the suitability and safety of using non-steroidal anti-inflammatory drugs as chemopreventive agents in the primary prevention of prostate cancer.