31 abstracts found.



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Docetaxel and/or zoledronic acid for hormone-naïve prostate cancer: First overall survival results from STAMPEDE(NCT00268476)

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Nicholas D James1,13,Matthew R Sydes2,Malcolm D Mason3,Noel W Clarke14,David P Dearnaley4,Melissa R Spears2,Robin Millman15,Christopher C Parker8,Alastair W S Ritchie2,J Martin Russell5,John Staffurth11,Robert J Jones5,Shaun P Tolan6,John Wagstaff7,Andrew Protheroe8,Rajaguru Srinivasan9,Alison J Birtle10,Joe M O’Sullivan11,Richard Cathomas12,Mahesh K B Parmar2

1University of Warwick, Coventry, UK,2MRC Clinical Trials Unit at UCL, London, UK,3Velindre Hospital, Cardiff, UK,4The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK,5Beatson West of Scotland Cancer Centre, Glasgow, UK,6Clatterbridge Cancer Centre, Wirral, UK,7South West Wales Cancer Institute, Swansea, UK,8University of Oxford Medical Oncology Department, Oxford, UK,9Royal Devon and Exeter NHS Foundation Trust, Exeter, UK,10Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK,11Belfast City Hospital, Belfast, UK,12Kantonsspital Chur, Chur, Switzerland,13Queen Elizabeth Hospital, Birmingham, UK,14The Christie and Salford Royal Hospitals, Manchester, UK,15Prostate Cancer Support Group, Middlesbrough, UK


CheckMate 067: a phase III randomized double-blind study of nivolumab (NIVO) monotherapy or NIVO combined with ipilimumab (IPI) versus IPI monotherapy treatment-naïve patients (pts) with advanced melanoma (MEL)

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Jedd Wolchok1,Vanna Chiarion-Sileni2,Rene Gonzalez3,Piotr Rutkowski4,Jean Grob5,Charles Cowey6,Christopher Lao7,Dirk Schadendorf8,Pier Ferrucci9,Michael Smylie10,Reinhard Dummer11,Andrew Hill12,John Haanen13,Michele Maio14,Grant McArthur15,Arvin Yang16,Linda Rollin17,Christine Horak16,James Larkin18,Stephen Hodi19

1Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA,2Oncology Institute of Veneto IRCCS, Padua, Italy,3University of Colorado Cancer Center, Denver, CO, USA,4Maria Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland,5Hospital de la Timone, Marseille, France,6Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, TX, USA,7University of Michigan, Ann Arbor, MI, USA,8Department of Dermatology, University of Essen, Essen, Germany,9European Institute of Oncology, Milan, Italy,10Cross Cancer Institute, Edmonton, AB, Canada,11Universitäts Spital, Zurich, Switzerland,12Tasman Oncology Research, Queensland, Australia,13Netherlands Cancer Institute, Amsterdam, The Netherlands,14Medical Oncology and Immunotherapy, University Hospital of Siena, Siena, Italy,15Peter MacCallum Cancer Centre, Victoria, Australia,16Bristol-Myers Squibb, Princeton, NJ, USA,17Bristol-Myers Squibb, Wallingford, CT, USA,18Royal Marsden Hospital, London, UK,19Dana-Farber Cancer Institute, Boston, MA, USA


PET-NECK: A multi-centre, randomized, phase III, controlled trial (RCT) comparing PETCT guided active surveillance with planned neck dissection (ND) for locally advanced (N2/N3) nodal metastases (LANM) in patients with head and neck squamous cell cancer (HNSCC) treated with primary radical chemoradiotherapy (CRT)

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Hisham Mehanna1,Wai Lup Wong2,Christopher A McConkey3,Joy K Rahman3,Max Robinson4,Andrew Hartley5,Christopher Nutting6,Ned Powell7,Hoda Al-Booz8,Martin Robinson9,Elizabeth Junor10,Claire Hulme11,Alison F Smith11,Peter Hall12,Bal Sanghera2,Janet A Dunn3

1InHANSE, University of Birmingham, Birmingham, UK,2Paul Strickland Scanner Centre, Mount Vernon Hospital, Middlesex, UK,3Warwick University Clinical Trials Unit, Coventry, UK,4Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle, UK,5Queen Elizabeth Hospital Birmingham, Birmingham, UK,6Royal Marsden Hospital, London, UK,7HPV Oncology Group, Institute of Cancer Genetics, Cardiff University, Cardiff, UK,8Bristol Haematology and Oncology Centre, Bristol, UK,9Weston Park Hospital, Sheffield, UK,10Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK,11University of Leeds, Leeds, UK,12St James University Hospital, Leeds, UK


A phase II/III randomised trial comparing maintenance lapatinib vs placebo after first line chemotherapy in HER1/2 positive metastatic bladder cancer

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Simon Chowdhury2,Tony Elliot3,Robert Jones4,Syed Hussain5,Simon Crabb6,Charlotte Ackerman1,Satinder Jagdev7,John Chester7,Serena Hilman8,Mark Beresford8,Graham Macdonald9,Sundar Santhanam10,John Frew11,Andrew Stockdale12,Shah-Jalal Sarker1,Dan Berney1,Thomas Powles1,Robert Huddart13

1Barts Cancer Institute, London, UK,2Guy’s and St Thomas’ Hospital NHS Trust, London, UK,3The Christie NHS Foundation Trust, Manchester, UK,4Beatson West of Scotland Cancer Centre, Glasgow, UK,5The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool, UK,6University Hospital Southampton NHS Foundation Trust, Southampton, UK,7St James’s University Hospital, Leeds, UK,8Bristol Haematology and Oncology Centre, Bristol, UK,9Aberdeen Royal Infirmary, Aberdeen, UK,10Nottingham University Hospitals NHS Trust, Nottingham, UK,11Freeman Hospital, Newcastle, UK,12University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK,13Royal Marsden Hospital, Surrey, UK


Development of novel imaging methods in mouse cancer models

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Kevin Brindle1

1University of Cambridge, Cambridge, UK


Overall survival benefit of radium-223 chloride (Alpharadin™) in the treatment of patients with symptomatic bone metastases in castration-resistant prostate cancer (CRPC): A phase III randomized trial (ALSYMPCA)

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Christopher Parker1, Daniel Heinrich2, Joe M. O'Sullivan3, Sophie Foss
1The Royal Marsden Hospital, Surrey, UK, 2Haukeland University Hospital, Bergen, Norway, 3Centre for Cancer Research and Cell Biology, Queen

Comparing BRAF inhibitor vemurafenib with dacarbazine (DTIC) in patients with V600EBRAF-mutated melanoma: A Phase III randomised, open-label, multicentre trial (BRIM3)

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James Larkin1, Paul B. Chapman2, Grant A. McArthur3, Paul Lorigan4, Paul Nathan5, Mark R. Middleton6, Axel Hauschild7
1Royal Marsden Hosptial, London, UK, 2Memorial Sloan-Kettering Cancer Center, New York, USA, 3Peter MacCallum Cancer Centre, Melbourne, Australia, 4University of Manchester, Manchester, UK, 5Mount Vernon Hospital, London, UK, 6University of Oxford Cancer Centre, Oxford, UK, 7University of Kiel, Kiel, Germany

Optimal sequencing of adjuvant chemotherapy (CT) and radiotherapy (RT) for women with early breast cancer (EBC): results of the SECRAB trial. Presented on behalf of the SECRAB Steering Committee

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Indrajit Fernando1, Sarah Bowden2,1, Deborah Stocken2, Robert Grieve3, David Spooner1, Rajiv Agrawal4, Murray Brunt5, Mark Churn6, Andrea Stevens1, Andrea Marshall7, Daniel Rea2,1, Peter Canney8
1University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK, 2University of Birmingham, Birmingham, UK, 3University Hospital, Coventry, UK, 4Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, UK, 5University Hospital North Staffordshire, Stoke on Trent, UK, 6New Cross Hospital, Wolverhampton, UK, 7University of Warwick, Warwick, UK, 8Beatson West of Scotland Cancer Centre, Glasgow, UK

Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukaemia and deletion of TP53: Final results of the National Cancer Research Institute (NCRI) CLL206 Trial

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Andrew R Pettitt1,2, Richard Jackson1, Stacey Carruthers1, James Dodd1, Susanna Dodd1, Gillian G Johnson1, Anna Schuh3, Estella Matutes4, Claire Dearden4, Daniel Catovsky4, John Radford5,6, Adrian Bloor5,6, George A Follows7, Stephen Devereux8, Anton Kruger9, Julie Blundell9, Samir Agrawal10, David Allsup11, Stephen Proctor12, Earnest Heartin13
1University of Liverpool, Liverpool, UK, 2Royal Liverpool & Broadgreen University Hospitals NHS Trust, Liverpool, UK, 3Oxford Radcliffe Hospitals NHS Trust, Oxford, UK, 4Institute of Cancer Research and Royal Marsden Hospital NHS Trust, Surrey, UK, 5The University of Manchester, Manchester, UK, 6Christie NHS Foundation Trust, Manchester, UK, 7Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK, 8King's College Hospital NHS Foundation Trust, London, UK, 9Royal Cornwall Hospitals NHS Trust, Cornwall, UK, 10Barts and The London NHS Trust, London, UK, 11Hull and East Yorkshire Hospitals NHS Trust, Hull, UK, 12University of Newcastle, Newcastle, UK, 13Conwy & Denbighshire NHS Trust, North Wales, UK, 14Royal Bournemouth and Christchurch Hospitals NHS Foundation Trust, Bournemouth, UK, 15Leeds Teaching Hospitals NHS Trust, Leeds, UK

Final analysis of intergroup randomized phase III study of androgen deprivation therapy (ADT) + radiation therapy (RT) in locally advanced prostate cancer (CaP) (NCIC-CTG, SWOG, MRC-UK, INT: T94-0110)

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Malcolm Mason1, Matthew Sydes2, Wendy Parulekar3, Mahesh Parmar2, John Anderson4, Jim Barber5, Michael Brundage3, Richard Cowan6, Mary Gospodarowicz7, Charles Hayter8, John Hetherington9, Andrea Hiltz3, Peter Kirkbride10, Edward Kostashuk11, Karen Sanders2, Jinka Sathya12, Gregory Swanson13, Bingshu Chen3, Padraig Warde7
1Cardiff University, Cardiff, UK, 2MRC Clinical Trials Unit, London, UK, 3NCIC Clinical Trials Group, Kingston, Ontario, Canada, 4The Royal Hallamshire Hospital, Sheffield, UK, 5Velindre Hospital, Cardiff, UK, 6The Christie NHS Foundation Trust, Manchester, UK, 7Princess Margaret Hospital and University of Toronto, Toronto, Canada, 8Credit Valley Hospital, Mississauga, Canada, 9Castle Hill Hospital, Hull, UK, 10Weston Park Hospital, Sheffield, UK, 11British Columbia Cancer Agency, Surrey, British Columbia, Canada, 12CancerCare Manitoba, Winnipeg, Canada, 13University of Texas Health Science Centre at San Antonio, San Antonio, Texas, USA

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