341 abstracts found.



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Discovery of potent, selective and orally bioavailable CDK8/CDK19 kinase modulators

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Aurélie Mallinger,1 Kai Schiemann,2 Christian Rink,1 Frank Stieber,2 Simon Crumpler,1 Mark Stubbs,1 Olajumoke Adeniji-Popoola,1 Oliver Poeschke,2 Michael Busch,2 Paul Czodrowski,2 Djordje Musil,2 Daniel Schwarz,2 Maria-Jesus Ortiz-Ruiz,1 Richard Schneider,2 Melanie Valenti,1 Alexis de Haven Brandon,1 Rosemary Burke,1 Paul Workman,1 Trevor Dale,3 Dirk Wienke,2 Paul Clarke,1 Christina Esdar,2 Florence Raynaud,1 Suzanne Eccles,1 Felix Rohdich2 and Julian Blagg1

1The Institute of Cancer Research, London 2Merck KGaA, Darmstadt, Germany 3School of Bioscience, Cardiff University


Focal Adhesion Kinase – a new target in cancer immunotherapy

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Alan Serrels1

1MRC Centre for Inflammation Research, Queen’s Medical Research Institute, University of Edinburgh


R-spondin gain-of-function in colorectal cancer – a comparison between mature tumours and precursor polyps

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Sam Kleeman1,Roland Arnold1,on behalf of S-CORT Consortium2,Tim Maughan3,Simon Leedham1
1Wellcome Trust Centre for Human Genetics,2S-CORT Consortium,3CRUK/MRC Oxford Institute for Radiation Oncology

EORTC Perspectives on QOL in clinical trials

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Andrew Bottomley1
1EORTC

Advances in the measurement of patient-reported outcomes

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John Ware1
1University of Massachusetts Medical School

Web-based system to monitor cancer patients’ physical symptoms during active treatment-engaging patients and clinicians

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Galina Velikova1
1University of Leeds

Patient-reported outcomes for adverse event and symptom monitoring in oncology

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Ethan Basch1
1University of North Carolina at Chapel Hill

Challenges and opportunities for quality of life and symptom assessment in cancer clinical trials

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Melanie Calvert1
1University of Birmingham

WNT signalling and the Mediator complex associated kinases CDK8/19

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Julian Blagg1
1The Institute of Cancer Research

Fixation and spread of somatic clones in adult human colon

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Anna Nicholson1
1Cancer Research UK

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