7 abstracts found.



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Introduction: integration of germline genetic information can improve cancer diagnoses, treatment and prevention

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Germline genomics and predisposition to serious adverse drug reactions with anti-cancer drugs

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Munir Pirmohamed1

1University of Liverpool, Liverpool, UK


Interventional genetics

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John Burn1

1Newcastle University, Newcastle, UK


Integration of germline genetic information can improve cancer diagnosis, treatment and prevention

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Nazneen Rahman1,2

1Institute of Cancer Research, London, UK,2Royal Marsden, London, UK


Mutations in the transcriptional repressor REST predispose to Wilms tumour

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Shazia Mahamdallie1,Sandra Hanks1,Kristen Karlin2,3,Anna Zachariou1,Elizabeth Perdeaux1,Elise Ruark1,Chad Shaw3,Alexander Renwick3,Emma Ramsay1,Shawn Yost1,Anna Elliot1,The Wilms Tumor Susceptibility Collaboration (WTSC)1,Michael Capra4,Thomas McLean5,Anthony Renwick1,Sheila Seal1,Charles Stiller6,Neil Sebire7,Thomas Westbrook2,3,Nazneen Rahman1,8

1Division of Genetics & Epidemiology, Institute of Cancer Research, London, UK,2Verna & Marrs McLean Dept. of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA,3Dept of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA,4Our Lady’s Children’s Hospital, Dublin, UK,5Wake Forest University School of Medicine, Winston-Salem, USA,6Public Health England, Oxford, UK,7Dept of Histopathology and Paediatric Laboratory Medicine, Great Ormond Street Hospital, London, UK,8Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust, London, UK


Mutations in the transcriptional repressor REST predispose to Wilms tumour

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Shazia Mahamdallie1,Sandra Hanks1,Kristen Karlin2,3,Anna Zachariou1,Elizabeth Perdeaux1,Elise Ruark1,Chad Shaw3,Alexander Renwick3,Emma Ramsay1,Shawn Yost1,Anna Elliot1,The Wilms Tumor Susceptibility Collaboration (WTSC)1,Michael Capra4,Thomas McLean5,Anthony Renwick1,Sheila Seal1,Charles Stiller6,Neil Sebire7,Thomas Westbrook2,3,Nazneen Rahman1,8

1Division of Genetics & Epidemiology, Institute of Cancer Research, London, UK,2Verna & Marrs McLean Dept. of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA,3Dept of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA,4Our Lady’s Children’s Hospital, Dublin, UK,5Wake Forest University School of Medicine, Winston-Salem, USA,6Public Health England, Oxford, UK,7Dept of Histopathology and Paediatric Laboratory Medicine, Great Ormond Street Hospital, London, UK,8Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust, London, UK


Young patients with HER2+ breast cancer rarely have a germline mutation in a known cancer predisposition gene

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Diana Eccles1,Li Na2,Tom Maishman1,Ellen Copson1,Ian Campbell2

1University of Southampton, Southampton, UK,2Peter Macallum Cancer Centre, Melbourne, Australia