614 abstracts found.



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The Role of KSRP in the Alternative Splicing of the Fibroblast Growth Factor Receptor 2 in Triple Negative Breast Cancer

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Kiashanee Moodley1,Kurt Lightfoot2,Caroline Dickens1,Therese Dix-Peek1,Juan Valcárcel2,Raque Duarte1,Gwendal Dujardin2

1Department of Internal Medicine, Faculty of Health Sciences, Johannesburg, South Africa,2Gene Regulation, Stem Cells and Cancer, Centre de Regulació Genòmica, Barcelona, Spain


An assessment of PARP-1 inhibition in combination with external beam x-radiation in the treatment of neuroblastoma

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Iain Hyndman1,Donna Nile1,Colin Rae1,Mark Gaze2,Robert Mairs1

1Radiation Oncology, Institute of Cancer Sciences, Glasgow, UK,2Great Ormond Street Hospital, London, UK


Characterisation of the mucin receptor MUC1 in the progression to oesophageal cancer and potential for antibody directed therapy.

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Mohammed Adil Butt2,1,Hayley Pye1,SUR Khan1,I Puccio1,H Reinert1,E Bloom1,M Gandy1,M Rashid7,M Deonarain3,D Swallow6,M Banks2,M Rodriguez-Justo5,R Hamoudi1,M Novelli5,LB Lovat1,2,RJ Haidry2,D Oukrif5

1Department for Tissue & Energy, University College London, London, UK,2Upper Gastrointestinal Service, University College London, London, UK,3Antikor BioPharma, Stevenage Bioscience Catalyst, Stevenage, UK,4Antikor BioPharma, Stevenage Bioscience Catalyst, Stevenage, UK,5Department of Pathology, University College London, London, UK,6Genetics, Evolution & Environment, Division of Biosciences, University College London, London, UK,7Department of Oncology, UCL Cancer Institute, London, UK


Can we use N-acetyl-l-aspartyl-l-glutamate peptidase-like 2 to target drugs to cancer cells?

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Hannah Luxton1,B Simpson1,J Kay1,S Menon3,M Brown2,N Clarke2,H Whitaker1

1Molecular Diagnostics and Therapeutics Group, London, UK,2Genito Urinary Cancer Research Group, Institute for Cancer Sciences, Manchester, UK,3Bioinformatics Core Facility, Cancer Research UK Cambridge Institute, Cambridge, UK


How many lives will bowel cancer screening save if we improve participation in Merseyside? 

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Matthew Saunders1,Daniel Seddon2

1Public Health England, Cjesjire&Merseyside, UK,2NHS England North, London, UK


“Identifying novel transcriptional downregulators of MCL-1 to induce apoptosis in pancreatic cancer”

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Mateus Milani1

1University of Liverpool, Liverpool, UK


Comparison of different NGS library construction methods for single cell sequencing

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Peter Hahn1,Rumeysa Akinci-Tolun1,Isabell Haupt1,Ioanna Andreou1,Christian Korfhage1,Nan Fang1

1QIAGEN GmbH, QIAGEN Strasse, Hilden, Germany


PRospective observational assessment of the effectiveness of Enzalutamide treatment in patients with Metastatic castration-resIstant proState cancEr in a real-world clinical practice setting: the ongoing PREMISE study

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Heather Payne1,Michael Borre2,Richard Davidson3,Robert Snijder4,Maria De Santis5

1University College London Hospitals, Department of Oncology, London, UK,2Aarhus University Hospital, Department of Urology, Aarhus, Denmark,3Astellas Pharma EMEA, Chertsey, UK,4Astellas Pharma Global Development, Leiden, The Netherlands,5University of Warwick, Cancer Research Unit, Coventry, UK


A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy.

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Hayley Pye1,Mohammed Adil Butt1,2,Halla Reinert1,Antoine Maruani3,Jared Marklew4,Joao Nunes3,Maryam Qurashi1,5,Laura Funnel1,Abi May1,James Baker3,Mark Smith3,Stephen Caddick3,Gokhan Yahioglu4,5,Mahendra Deonarain4,Vijay Chudasama3,Laurence Lovat1,2

1Department for Tissue & Energy, University College London, London, UK,2Upper Gastrointestinal Service, University College Hospital, London, UK,3Department of Chemistry, University College London, London, UK,4Antikor BioPharma, Stevenage Bioscience Catalyst, London, UK,5Department of Chemistry, Imperial College London, London, UK


Primary versus metastasis using iontorrent next generation sequencing (PRIMINGS)

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David Moore1,2,Luke Martinson1,William Dalleywater2,Jacqui Shaw1,John Le Quesne1,2

1University of Leicester, Leicester, UK,2University Hospitals Leicester, Leicester, UK


Oncology and Haematology Clinical Trials (OHCT) -What is the Role of the Clinical Trial Practitioner (CTP)?

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Harriet Jones1,Rachel Todd1,Piranavan Sucindran1,Nicholas Gomm1

1Guy’s and St Thomas’ Foundation NHS Trust, London, UK


Apical SLC9A3R1 links high-grade colorectal cancer morphology to genomic instability

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Jane McClements1,Ravi Deevi1,Arman Javadi1,Lisa Rainey1,Maurice Loughrey2,1,Frederick Campbell1

1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, Belfast, UK,2Department of Histopathology, Royal Victoria Hospital, Belfast, UK


Circulating RNA in prostate cancer reveals novel androgen regulated genes that predict poor outcome

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Benjamin Thomas1,Jonathan Kay2, Suraj Menon1, Sarah Vowler1, Sarah Dawson1, Hayley Luxton1, Thomas Johnson1, Charlie Massie1, Michelle Osbourne1, Anne Warren3, Keith Burling3, Andy Lynch1,Anne George4, Marie Corcoran4, Johannah Burge4, Sara Stearn4, Alastair Lamb1, Greg Shaw1, David Neal1, Hayley Whitaker3

1CRUK Cambridge Institute, Cambridge, UK,2University College London, London, UK,3Addenbrookes Hospital, Cambridge, UK,4University of Cambridge, Cambridge, UK,5University of Oxford, Oxford, UK


Quit With Us: A pro-active community based smoking cessation intervention 

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Tim Banks1,Maura Matthews1,Gail Hughes1,Jess Bridgeman1,Ian Lewis1

1Tenovus Cancer Care, Cardiff, Wales, UK


Research by researchers selected by patients: Research by patients selected by researchers

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Ian Lewis1,Anita Howman1,Corinne Squire2,Sue Bevan2,Stephen Thomas1

1Tenovus Cancer Care, Cardiff, Wales, UK,2Cardiff University, Cardiff, Wales, UK


Control of cell migration in normal and neoplastic neural stem cells via a PML/EZH2-mediated regulatory loop

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Deli A1,2,Valeria Amodeo1,2,Joanne Betts1,2,Stefano Bartesaghi1,2,Mikaella Vouri1,2,Rozita Roshani1,2,Sarah Oberndorfer1,2,Maya Shaked-Rabi3,David Dinsdale4,Pierluigi Nicotera5,Chris Jones6,David Michod1,2,Sebastian Brandner3,Paolo Salomoni1,2

1UCL Cancer Institute, London, UK,2Samantha Dickson Brain Cancer Unit, London, UK,3UCL Institute of Neurology, London, UK,4MRC Toxicology Unit, Leicester, UK,5DZNE, Bonn, Germany,6Institute of Cancer Research, Sutton, UK,7UCL Institute of Child Health, London, UK


Decreased Serum Thrombospondin-1 Levels in Pancreatic Ductal Adenocarcinoma Patients: An Early Indicator of Disease or Diabetes Mellitus Development?

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Claire Jenkinson1,2,Victoria Elliott1,2,Anthony Evans1,2,Lucy Oldfield1,2,Rosalind Jenkins3,John Timms4,Darragh O’Brien4,Sophia Apostolidou4,Aleksandra Gentry-aharaj4,Evangelia Fourkala4,Ian Jacobs4,5,Usha Menon4,Trevor Cox1,Fiona Campbell6,Robert Sutton1,2,Stephen Pereira7,David Tuveson8,Kevin Park3,William Greenhalf1,2,John Neoptolemos1,2

1Department of Molecular and Clinical Cancer Medicine, Liverpool, UK,2National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, Liverpool, UK,3MRC Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Liverpool, UK,4Department of Women’s Cancer, Institute for Women’s Health, London, UK,5Faculty of Medical & Human Sciences, 1.018 Core Technology Facility, Manchester, UK,6Department of Pathology, Liverpool, UK,7Institute for Liver and Digestive Health, London, UK,8Cold Spring Harbor Laboratory, New York, USA


Incorporating epistasis interaction of genetic susceptibility Single Nucleotide Polymorphisms in a lung cancer risk prediction model

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Michael W. Marcus1,Olaide Y. Raji1,Stephen W. Duffy2,Robert P. Young3,Raewyn J. Hopkins3,John K. field1

1Roy Castle Lung Cancer Research Programme, the University of Liverpool Cancer Research Centre, Institute of Translational Medicine, the University of Liverpool. Liverpool L3 9TA, UK, Liverpool, UK,2Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, London, UK,3School of Biological Sciences; Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, Auckland, New Zealand


A prospective study of anal cancer screening amongst three high risk groups; Final results of the ANALOGY study.

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Alice Schofield1,Laura Sadler1,Linsey Nelson1,Julie Burnett1,Sheila Russell2,Matthew Gittins3,Mina Desai4,Alexandra Sargent5,Raymond McMahon6,Ashish Suckthankar7,Stephen Higgins8,James Hill9,Emma Crosbie1,Julietta Patnick10,Henry Kitchener1

1Institute of Cancer Sciences, University of Manchester, Manchester, UK,2Renal Transplant Unit, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,3Institute of Population Health, University of Manchester, Manchester, UK,4Manchester Cytology Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,5Clinical Virology, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,6Histopathology Department, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,7Manchester Centre for Sexual Health, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,8Department for Sexual Health and HIV, North Manchester General Hospital, Pennine Acute Hospital NHS Trust, Manchester, UK,9General Surgery, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,10Public Health England, Sheffield, UK


Role of Protein Phosphatase 4 in Chronic Myeloid Leukaemia

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Sundus Al-Khazraji1,Mirna Mourtada-Maarabouni1

1Keele University, Staffordshire, UK


Medicines and Consumables Wastage: Clinical Research Unit (CRU) Audit 2015

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Cyper Allan1,Katharine Williams1,Catharine Spalton1

1University of Sheffield, Sheffield, South Yorkshire, UK


Sarah Cannon Research Institute UK (SCRI UK) and University College London – Advanced Diagnostics (UCL-AD) Genomics Review Board (GRB) Implementation and Experience

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Gabriel Mak1,Teresa Curiel1,Saeed Rafii1,Mark Voskoboynik1,Nataliya Rozumna-Martynyuk1,David Collin1,3,Phil Bennett2,Debbie Haynes1,Charles Swanton3,Hendrik-Tobias Arkenau1

1Sarah Cannon Research Insitute UK, London, UK,2University College London – Advanced Diagnostics, London, UK,3University College London Hospitals and Cancer Institute, London, UK


Initial experience of an algorithm-based programme for the community follow-up of patients with stable prostate cancer

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Jessica Little1,Philip Goodall1,Eleanor Robinson1,Ian Trimble2,Owen Cole3,Thomas Walton1,

Department of Urology, Nottingham University Hospitals NHS Trust, Nottingham, UK1,Nottingham City Clinical Commissioning Group, Nottingham, UK2,Royal Guernsey Hospital, Guernsey, UK3


Increasing the frequency of physical activity very brief advice for cancer patients.  Development of an intervention using the Behaviour Change Wheel. 

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Justin Webb1,2,Jo Foster1,Edward Poulter1

1Macmillan Cancer Support, London, UK,2University of Hertfordshire, Hertfordshire, UK


Tumour-induced reprogramming of hepatic metabolism causes failure of anti-cancer immunotherapy

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Thomas Flint1,Tobias Janowitz1,2,Claire Connell1 (presenting),Ian Beh1,Edward Roberts5,Alice Denton3,Anthony Coll4,Duncan Jodrell1,Douglas Fearon6,7

1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK,2Department of Oncology, University of Cambridge, Cambridge, UK,3Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK,4University of Cambridge Metabolic Research Laboratories, Cambridge, UK,5Department of Pathology, University of California, San Francisco, CA, USA,6Cold Spring Harbor Laboratory, NY, USA,7Weill Cornell Medical College, New York, NY, USA


Increasing the frequency of physical activity very brief advice for cancer patients – a mixed methods feasibility study of a training intervention for nurses.

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Justin Webb1,2,Jen Hall3,Kirsten Hall4,Raheelah Ahmad2

1Macmillan Cancer Support, London, UK,2University of Hertfordshire, Hertfordshire, UK,3Brunel University, London, UK,4Bath University, Bath, UK


Lung Metastectomy and Colorectal Cancer: Patient Outcomes and Prognostic Factors

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Ciara O’Brien1,Rachel Broadbent1,Kandadai Rammohan2,Michael Braun1

1The Christie Hospital NHS Foundation Trust, Manchester, UK,2University Hospital of South Manchester NHS Foundation Trust, Manchester, UK


Survival-predictive cell surface proteins in multiple myeloma: Mining publicly available gene expression data to identify novel biomarkers and targets for therapy

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Jason Sangha1,2

1Leeds Teaching Hospitals NHS Trust, Leeds, UK,2Leeds Institute of Cancer & Pathology, University of Leeds, Leeds, UK


CD15/FUT4 overexpression on cancer cells decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.

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Guido Giordano1,Pietro Parcesepe2,Massimo Pancione3

1Medical Oncology Unit, Fatebenefratelli Hospital, Benevento, Italy,2Department of Pathology and Diagnostics, University of Verona, Verona, Italy,3Department of Sciences and Technologies, University of Sannio, Benevento, Italy


A novel highly invasive transitional phenotype during development of gefitinib resistance in oral squamous cell carcinoma is linked to activation of the PI3K/Akt pathway

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Julie Hamilton1,David Argyle2,Gura Bergvist2,Donald Yool2

1Roslin Institute, University of Edinburgh, Easter Bush, Roslin, Midlothian, UK,2Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush, Roslin, Midlothian, UK


standardisation of high throughput spheroid engineering using the labcyte echo acoustic dispenser

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michelle barnard2,adrienne flanagan2,susanne scheipl2,aurore lejeune1

1Labcyte, Sunnyvale, USA,2UCL Cancer Institute, London, UK


90 day mortality in radical radiotherapy – a retrospective population based study of 18,300 treatment episodes

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Katie Spencer1,2,Eva Morris2,Emma Dugdale1,Rebecca Birch2,Rob Turner1,David Sebag-Montefiore2,1,Geoff Hall1,2,Adrian Crellin1

1Leeds Cancer Centre, Leeds, UK,2University of Leeds, Leeds, UK


The Vacuolar ATPase Subunit E regulates cell death in human breast cancer cells

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Saja Mohammed1,Mirna Mourtada-Maarabouni1

1Keele University, Staffordshire, UK


An audit of Trabectedin for the treatment of incurable soft tissue sarcoma, five years of patient experience in the Northern Centre for Cancer Care (NCCC), Newcastle upon Tyne

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Jane Margetts1,Elizabeth Reay1,Radha Todd1,Mark Verrill1

1Northern Centre for Cancer Care, Newcastle upon Tyne, UK


Modifying the cut and thrust of cancer cells – the influence of the oncogene LYRIC/AEG-1 on gene splicing

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Hayley Luxton1,Nicola Brindle1,Ian Mills1,2,David Neal1,Hayley Whitaker1

1University of Cambridge, Cambridge, UK,2University of Oslo, Oslo, Norway


The Role of the Clinical Trials Set Up Specialist: From Protocol to Patient Trial Initiation within the Oncology Haematology Clinical Trials Team (OHCT)

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Sheela Medahunsi1,Nicholas Gomm1

1Guys and St Thomas’ NHS Foundation Trust, London, UK


Three cancer groups to explain the different complexity, intensity and longevity of broad clinical needs

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Rachel White1,Hannah McConnell1,Jane Maher1,2

1Macmillan Cancer Support, London, UK,2Mount Vernon Cancer Centre, Middlesex, UK


Aspirin inhibits mTOR signalling, protein synthesis and translation in colorectal cancer

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Asta Valanciute1,Karen Dunbar1,Malcolm Dunlop1,Farhat Din1

1Institute of Genetics and Molecular Medicine, Edinburgh, UK


Computational tools for studying chromosome dynamics and instability

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Elina Vladimirou1,Andrew McAinsh1

1University of Warwick, Coventry, UK


Synthetic Tumor Networks for Translational Studies

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Gareth Bolitho1,Ashley Smith2,Charles Garson2,Balabhaskar Prabhakarpandian2,Kapil Pant2

1Stratech Scientific Ltd, Newmarket, UK,2Synvivo, AL, USA


Stimulated DW-MRI for radiotherapy planning: improving radiotherapy induced xerostomia in head and neck cancer patients

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Jonathan Wyatt1,Rachel Pearson2,Andrew Blamire2,Charles Kelly1,Jill McKenna1,Jim Snell1,Hazel McCallum1

1Northern Centre for Cancer Care, Newcastle upon Tyne, UK,2Newcastle University, Newcastle upon Tyne, UK


microRNA-449a impedes the growth and invasion of brain tumour initiating cells

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Kastytis Sidlauskas1,Ningning Li1,Ying Zhang1,Sebastian Brandner1

1University College London, London, UK


Targeting arginine auxotrophy in colorectal cancer

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Constantinos Alexandrou1,Saif Sattar1,Jennifer Higgins1,Hong Cai1,Mafalda Pires-Damaso1,Ankur Karmokar1,Lynne Howells1,Andreas Gesher1,Catherine Andreadi1,Karen Brown1,Alessandro Rufini1

1University of Leicester, Leicester, UK


Genome-wide DNA methylation and gene expression profiling of cancer-associated myofibroblasts (CAM) identifies cancer-induced DNA methylation changes that may regulate CAM-specific gene expression

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Hanna Najgebauer1,Triantafillos Liloglou2,Andrea Varro1,Christopher M Sanderson1

1Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK,2Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK


Frameworks for understanding the cancer population

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Hannah McConnell1,Rachel White1,Jane Maher1,2

1Macmillan Cancer Support, London, UK,2Mount Vernon Cancer Centre, London, UK


Defining stromal characteristics which can predict neoadjuvant chemotherapy response in breast cancer

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Celine Pourreyron1,Patsy Whelehan1,Philip Coates1,Andrew South2,Sarah Vinnicombe1,Alastair Thompson3,Andrew Evans1,Frances Fuller-Pace1

1University of Dundee, Dundee, UK,2Thomas Jefferson University, Philadelphia, USA,3The University of Texas MD Anderson Cancer Center, Houston, USA


PTEN regulates cdc42-dependent morphogenesis through ?-arrestin1/ARHGAP21 signalling.

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Arman Javadi1,Ravi Deevi1,Charles Campbell1

1Centre for Cancer Research and Cell Biology, Belfast, UK


Developing a device to immobilize the breast during radiotherapy: A co-design approach with patients and health care professionals

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Heidi Probst1,Heath Reed1,Keeley Rosbottom1,Andrew Stanton1,Helen Crank1,Christopher Bragg2,Karen Collins1

1Sheffield Hallam University, Sheffield, UK,2Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK


A retrospective observational study of length of stay in hospital after colorectal cancer surgery in England (1998-2010)

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Ariadni Aravani1,Elizabeth Samy2,James Thomas2,Phil Quirke1,Eva Morris1,Paul Finan1

1University of Leeds, Leeds, UK,2Public Health England, Leeds, UK


Molecular interactions between PAK4 and EGFR in ovarian carcinogenesis

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Ivy, Tsz-Lo Wong1,Oscar, Gee-Wan Wong1,Annie, Nga-Yin Cheung1

1Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong