A162: A model for care: 6 year experience of recruitment into breast cancer trials- a single centre perspective
1Shrewsbury and Telford NHS Trust, Shrewsbury, Shropshire, UK
The National Institute for Health research advises of the need to see sustained improvement in the performance of NHS providers in initiating and delivering clinical research. At Shrewsbury and Telford NHS Trust a dedicated trials team have supported the breast oncology service to improve trials recruitment.
A dedicated trials team screens all breast oncology clinics against trial entry criteria. Patients are identified and a trials nurse is available in each clinic to discuss clinical trials where appropriate and provide an information pack. A follow up call is undertaken to confirm the patient's decision. A prospective log is kept of patients decisions and reviewed with the Principle Investigator to inform and highlight potential barriers to recruitment. Data for recruitment in to breast cancer trials from 2008- ongoing is presented.
From 2008- 2014 sixteen clinical trials were identified as open to recruitment during this time. Five Principle Investigators opened trials, 3 Consultants (2 Clinical Oncologists, 1 Surgeon) and 2 Research Nurses. Four trials were commercial trials. Over a 6 year period 1373 patients were identified from the trials screening program as eligible for entry, 547 were recruited, 354 declined entry and 68 were ineligible.
Target recruitment was specified in 11 trials and achieved in 5 trials. Where recruitment was not achieved identifying factors were established which included short recruitment window (3 trials), radiotherapy capacity, (1 trial), physics QA issues, (1 trial) patient ineligible after screening investigations (1 trial).
Over a 6 year period 1373 patients were identified as potentially eligible for opportunity to enter clinical trials and 39.8% accepted, 25.8 % declined, 5 % were subsequently ineligible.
A comprehensive screening program with a dedicated clinical trials team to support patients with information can enhance clinical trial recruitment and improve patient care. We support this as a model for care.