Abstract

Background

The study for original development of the tumorigenesis in the most earlier stage is still wild opened. The recent progress of the studies might provide fresh views for predicting the molecular mechanism of the most first step during the carcinogenesis.

Method

The methods of qPCR ,Western-blot and flow cytometry have been used in the present studies.

Results

First of all, our data indicated that a Survivin-NFkB and E2F1-Survivin circlets existed in the process of tumorigenesis. The following study data from ESCC tumor samples also indicated that the Survivin-NFkB circlet existed in the earlier stages of premalignant lesion in ESCC. The review data have also shown that there is a most earlier promotional mechanism for generating precancerous lesion with TNF-alpha-NFkB circlet appearing in the process of cell death induced inflammation.

Conclusion

Thus, we have the reasons to believe that carcinogens stimulated the cells to be in the processes of cell death(including necroses,necropoptosis, and apoptosis), which caused activation of TNF alpha-NFkB circlet, as long as these went through, the Survivin-NFkB circlet will be the next move to start and strengthen the activities of Survivin and interfere the normal cell via the aspects of apoptosis, cell cycles and cell proliferation to initiate the processing of tumorigenesis, and this circlet will continue to develop its biological influence to further drive the cells in the process of carcinogenesis.