Aberrant cell signalling in cancer


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Chris Marshall1
1Institute of Cancer Research, London, UK

Abstract

Thirty years ago we did not know the identity of a single gene involved in cancer. Now we know the identities of hundreds of genes that are altered in cancer. While cancer genes have numerous different functions it is clear that many of them, including HRAS the first human cancer geneto be isolated, control cell signalling mechanisms. Signalling determines whether a cell will grow and divide, survive or die, move or stay still. The study of aberrant cell signalling has presented many novel therapeutic opportunities. In this talk I will describe my lab's work on RAS signalling and how the family of RHO proteins control cancer movement and metastasis.