Development of core outcomes sets to be reported in clinical trials for curative treatment of upper gastrointestinal cancer: a systematic review of the literature


Year:

Session type:

Angus McNair1, Thomas Crosby2, Michael Griffin3, Jane Blazeby1

1University of Bristol, UK, 2Velindre Cancer Centre, Cardiff, UK, 3Royal Victoria Infirmary, Newcastle, UK

Abstract

Background

Selection of appropriate outcomes in randomised clinical trials is critical in the evaluation of both treatment arms. Inappropriate selection of outcomes may generate misleading information or omit important endpoints. Our aim was to systematically review studies that addressed the process of selecting endpoints to measure in clinical trials in curative treatment for upper gastrointestinal (UGI) cancer.

Method

A Medline systematic review was conducted for studies of the selection of outcomes for use in clinical trials in oesophageal, gastric and pancreatic cancer, with no restrictions.