EXACT: A multicomponent, feasibility, exercise trial for men with metastatic castrate-resistant prostate cancer.


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Gillian Prue1,Malcolm Brown1,Marie Murphy2,Helen McAneney1,Joe O'Sullivan1,Suneil Jain1
1Queen's University Belfast,2Ulster University

Abstract

Background

Men with metastatic castrate-resistant prostate cancer (MCRPC) experience many treatment-related side effects. Evidence suggests exercise may alleviate some of this disease burden, though empirical evidence in advanced prostate cancer remains limited. The purpose of this study is to determine whether men with metastatic prostate cancer can partake in a remotely supervised, moderate intensity exercise programme and any associated effects on quality of life and physical fitness.

Method

We plan to recruit 30 men with MCRPC. Participants are individually prescribed a home-based, moderate intensity 12 week exercise and behavioural intervention. The primary outcome is feasibility, hence we are evaluating recruitment and attrition rates to the study and adherence rates to the intervention. Secondary outcomes focus on skeletal events, the feasibility of patient reported outcome measures and the sampling time points. General physical fitness is assessed at regular intervals, using conventional exercise tests. Objective physical activity levels are captured for 7 days using an accelerometer. In parallel with the feasibility aspects, changes compared to baseline will be reported. Semi-structured interviews will be conducted with participants, non-participants, and health care professionals to determine the acceptability and accessibility of the intervention. This will be used to optimise the intervention for future effectiveness studies.

This study has received ethical approval and has been registered (NCT03658486).

Results

To date, 15 patients have been screened and deemed eligible. Six patients have consented with three currently on trial (100% adherence), while three further patients are considering the study invite. Six patients have declined participation (n 4 = not interested; n 1 = too busy; n 1 = too active).

Conclusion

This study aims to determine the potential utility of a home-based exercise intervention in managing treatment-related side effects. This feasibility trial will inform a larger randomised control trial, to determine the efficacy of such exercise as a low-toxicity adjuvant therapy.