Functional genomics and proteomics in pancreatic cancer research


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Joerg Hoheisel

German Cancer Research Center (DKFZ), Heidelberg, Germany

Abstract

Research at the Division of Functional Genome Analysis is aimed at the development and immediate application of new technologies for an analysis, assessment and description of both the realisation and regulation of cellular function from genetic information. Analyses on tumour material are at the centre of attention. Parallel studies at a global level are under way, for example, on the epigenetic modulation of gene promoters, variations in transcription factor binding, changes of transcript levels of coding and non-coding RNAs, on the actual protein expression and the intensity of protein interactions. From the resulting data, we aim at an understanding of cellular regulation and its biological consequences. In combination with clinical facts, the knowledge is used for the creation of means of early diagnosis, accurate prognosis and the analysis of treatment results as well as the establishment of new therapeutic approaches.

A more recent line of work aims at an in vitro implementation of complex biological processes. Motivation is a utilisation for the production of molecules and the establishment of artificial molecular systems. Cell-free biosynthetic production will become important for many biotechnological and pharmacochemical challenges ahead.