Gene-environment interactions and breast cancer: prospective evidence from 7610 women with breast cancer in a large UK cohort


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Ruth Travis1,Gillian Reeves1,Valerie Beral1
1Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom

Background

Genome-wide association studies, together with analyses of specific candidate polymorphisms, have identified a number of low-penetrance breast cancer susceptibility loci. Information is scarce about the combined effects on breast cancer incidence of these genetic variants and of environmental factors (reproductive, behavioural, and anthropometric risk factors for breast cancer). To test for evidence of gene-environment interactions, we compared genotypic relative risks for breast cancer across categories of the environmental risk factors.

Method

We tested gene¬Ėenvironment interactions in a nested case-control study of ¬†7610 women who developed breast cancer and 10,196 controls without the disease, studying the effects of 12 polymorphisms (FGFR2-rs2981582, TNRC9-rs3803662, 2q35-rs13387042, MAP3K1-rs889312, 8q24-rs13281615, 2p-rs4666451, 5p12-rs981782, CASP8-rs1045485, LSP1-rs3817198, 5q-rs30099, TGFB1-rs1982073, and ATM-rs1800054) in relation to prospectively collected information about ten established environmental risk factors (age at menarche, parity, age at first birth, breastfeeding, menopausal status, age at menopause, use of hormone replacement therapy, body-mass index, height, and alcohol consumption).

Results

We will present findings from this systematic investigation of gene-environment interactions in relation to breast cancer risk in a large UK cohort.

Conclusion

Results from a meta-analysis of these and other published data will also be shown.