Genomic analysis of Malaysian breast cancers unravel molecular differences from Caucasian breast cancers
Session type: Poster / e-Poster / Silent Theatre session
Breast cancer is the leading cause of cancer death among women. In Asia, breast cancer incidence shows growth over the past decades. Several appreciable differences exist between Asian and Caucasian breast cancers, for example younger age of incidence and higher prevalence of hereditary factors, hinting at crucial differences at the molecular level.
We performed whole exome sequencing (WES) on 576 Malaysian breast cancers (at median coverage 75X) and their matched normal blood (40X) to detect single nucleotide variations (SNVs) and small insertions and deletions (indels). We also performed shallow whole genome sequencing (sWGS) to detect major chromosomal aberrations.
We captured known copy number changes, together with major breast cancer genes and their phenotypes, for example high frequency of SNVs in hotspot regions in PIK3CA and indels in GATA3. We additionally show that Malaysian breast cancer show higher prevalence of TP53 as compared to Caucasian breast cancer cases, consistent with previous findings in Korean breast cancer samples.
Together, these results underlie the molecular differences between Asian and Caucasian breast cancers.