Humanising mouse models of cancer: how relevant are current models?


Session type:

Owen Sansom1
1Cancer Research UK Beatson Institute, Glasgow, UK


Genetically engineered mouse models (GEMMs) of cancer have been instrumental in studying cancer initiation, progression and evolution. There is great interest now in the mouse as a preclinical tool to identify new therapies and predict current regimes. However there are many differences between mouse and man; for example, drug metabolism and the immune system. This session will address current GEMM models to investigate drug treatments and the state of art work undergoing to humanise mouse models.