Implications of physical activity on CPET in a prostate cancer sample – feasibility trial


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Luke Robles1,Lucy Hackshaw-McGeagh1,Claire M Perks1,Hilary Taylor1,Stephen Tolchard2,Edward Rowe3,Jonathon Aning3,Raj Persad3,Anthony Koupparis3,J Athene Lane1,Richard M Martin1
1University of Bristol,2North Bristol NHS Trust,3Bristol Urological Institute

Abstract

Background

Evidence has shown moderate-vigorous physical activity to be associated with lowering prostate-cancer specific mortality. In particular, regular brisk walking after diagnosis of localised prostate cancer can prevent or delay cancer progression. This suggests that increasing men’s physical fitness before surgery has the potential to improve post-surgery outcomes, such as reducing cancer progression. However, little evidence is available to suggest whether this is feasible. We will, therefore, explore the impact of a brisk walking intervention on anaerobic threshold in men with localised prostate cancer pre-surgery.

Method

This feasibility trial will randomly allocate 20 men to either the 4-6 week (30 min, 5d/week) brisk walking intervention or a control group (usual level of physical activity). Eligible men will include those with localised prostate cancer recruited opportunistically from a urology outpatients department. Men will consent to participate in the trial using a novel electronic consent tool. Men’s anaerobic threshold will be measured by cardiopulmonary exercise testing (CPET), which assesses oxygen intake and measures of lung, heart, and circulatory function. Once randomised, men will undergo CPET followed by the intervention. At follow-up, men will undergo another CPET before their surgery. Blood samples will be taken before both CPET appointments and prostate tissue will be taken during surgery.

 

Results

This trial plans to start in September 2019 and will conclude in 2020.

Conclusion

Simple lifestyle changes before undergoing treatment for prostate cancer could provide a method of early intervention for prostate cancer progression. In addition, brisk walking could have beneficial effects to men’s physical fitness and quality of life.