Induction of thrombospondin-1 mediates the anti-angiogenic activity of dexrazoxane


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Stephanie Maloney1, Dianne Sullivan2, Steven Suchting2, Jonathan Barker3, Sudha Sundar4, Roy Bicknell1

1Institute for Biomedical Research, University of Birmingham, UK, 2Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK, 3St Johns Institute of Dermatology, Kings College London, UK, 4School of Cancer Sciences, University of Birmingham, UK

Abstract

Background

Considerable interest lies in the identification of novel anti-angiogenic compounds for cancer therapy. We have investigated whether dexrazoxane has anti-angiogenic properties and if so, the mechanism of the inhibition.

Method

The phenotypic effects of dexrazoxane on endothelial cell behaviour was investigated