Induction of thrombospondin-1 mediates the anti-angiogenic activity of dexrazoxane
Session type: Poster / e-Poster / Silent Theatre session
1Institute for Biomedical Research, University of Birmingham, UK, 2Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK, 3St Johns Institute of Dermatology, Kings College London, UK, 4School of Cancer Sciences, University of Birmingham, UK
Considerable interest lies in the identification of novel anti-angiogenic compounds for cancer therapy. We have investigated whether dexrazoxane has anti-angiogenic properties and if so, the mechanism of the inhibition.
The phenotypic effects of dexrazoxane on endothelial cell behaviour was investigated