Integration of cancer genome sequencing and dynamic functional imaging to assess the metabolic effects of metformin in breast cancer: a neoadjuvant window of opportunity clinical study


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Simon Lord1,2, Neel Patel3, Dan Liu3, John Fenwick3, Fergus Gleeson3, Syed Haider1,2, Francesca Buffa1, Adrian Harris1,2
1Department of Oncology, University of Oxford, Oxford, UK,2Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK,3Oxford Cancer Imaging Centre, University of Oxford, Oxford, UK

Abstract

Background

There is great interest in the effects on cancer metabolism of the diabetes drug, metformin and its potential as a cancer treatment. Despite intense investigation it is still not clear as to its metabolic effects on primary human cancer in vivo.