Introduction: DNA repair in cancer biology and treatment


Year:

Session type:

Chris Lord1
1The Institute of Cancer Research, London, UK

Abstract

Genomic instability is one of the most pervasive characteristics of tumour cells and is probably the combined effect of DNA damage and tumour-specific DNA repair defects. Although these processes drive genomic instability and ultimately the disease process, they also provide therapeutic opportunities.

In this session, we aim to discuss not only the precise molecular processes involved in DNA repair, but also how these systems shape the mutational spectrum of cancers. Finally, we will discuss how our growing understanding of DNA repair processes is informing the development of therapeutic approaches to the disease.