Introduction: Drug resistance modelling – patients, organoids and mice


Session type:

David Adams1
1Wellcome Trust Sanger Institute, Cambridge, UK


The aim of this session will be to discuss the problem of cancer drug resistance by the analysis of human samples, the use organoid culture systems, and also mice. The aim would be to have a state-of-the-art talk about the problem of drug resistance in the clinic and how molecular techniques are being used to understand it. This would be followed by a talk about how patient derived material can be used to screen in vitro for cancer drug sensitivities/resistance, and finally how mouse model systems may help provide mechanistic insights. The later should bring together PDX models and also engineered mice.