Introduction: What makes a target attractive for cancer drug discovery


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Donald Ogilvie1
1ancer Research UK Manchester Institute, Manchester, UK

Abstract

The selection of a molecular target for drug discovery involves careful consideration of the relevance of the target hypothesis to the unmet clinical need and the feasibility of the technical approach.  In terms of the latter, only a minor fraction of the expressed genome is accessible to drug modulation with current technologies.  Experts will discuss the factors to be considered in the selection and validation of novel molecular cancer targets and in the selection of small molecule and antibody approaches to drug discovery.