Latest Feasibility Outcomes from the Prostate cancer Evaluation of Exercise and Nutrition Trial (PrEvENT)


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Luke Robles1,Eleanor Shingler1,Lucy Hackshaw-McGeagh1,Raj Persad2,David Gillatt2,Jeff Holly3,Anthony Koupparis2,Edward Rowe2,Lyndsey Johnson4,Jenny Cloete4,Constance Shiridzinomwa4,Paul Abrams2,Chris Penfold1,Amit Bahl2,Jon Oxley5,Claire Perks3,Richard Martin6,Athene Lane6
1NIHR Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol,2Bristol Urological Institute, North Bristol NHS Trust, Southmead Hospital, Bristol,3School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol,4North Bristol NHS Trust, Southmead Hospital, Bristol,5Cellular Pathology, North Bristol NHS Trust, Southmead Hospital, Bristol,6School of Social and Community Medicine, University of Bristol

Abstract

Background

An increase in fruit and vegetable intake and physical activity have be associated with a reduced risk of prostate cancer recurrence.  The ongoing Prostate cancer Evaluation of Exercise and Nutrition Trial (PrEvENT) is a feasibility cohort study with a nested 2 x 3 factorial randomised controlled trial (RCT).  Its primary objectives are to evaluate the feasibility of allocating men randomly to a diet/physical activity intervention and their adherence to the interventions post-operatively. 

Method

Eligible participants were men aged  ≥18 years, diagnosed with localised (organ confined) prostate cancer, and undergoing radical prostatectomy (surgery).  Baseline measures were completed before surgery.  Participants were re-approached at 6 weeks following surgery and completed another set of measures.  Participants who consented to the RCT were randomised to 1 of 6 interventions with follow-ups at 3 and 6 months.  There was no further follow-up for participants who were not randomised. 

Results

A total of 108 men (mean age = 64, SD = 6.62) were recruited into the cohort study.  A total of 80 men have consented to the RCT and have been randomised to an intervention:  lycopene supplements (n = 13), plant-based diet (n = 13), brisk walking (n = 14), lycopene supplements with brisk walking (n = 14), plant-based diet with brisk walking (n = 14), and control (n = 12).   The trial has shown good retention of participants at 3-month and 6-month follow-up (% dropout = 5% and 1% respectively). 

Conclusion

The findings suggest that it is feasible to randomise and retain men to dietary and physical activity interventions post-operatively.  These findings will help to inform the development of a larger RCT to evaluate the effects of diet and physical activity on prostate cancer related outcomes.