Outcomes of Solitary Fibrous Tumours


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James Miller1,Robert Ashford2
1NHS,2East Midlands Sarcoma Service

Abstract

Background

Introduction: Solitary Fibrous Tumours are a rare sarcoma histotype, usually treated by surgical resection. A proportion of these patients go on to develop local recurrence or metastatic disease but the relative incidence of these occurring varies widely in the literature.

Aims: To review the clinical and oncological outcomes of patients with Solitary Fibrous Tumours (SFT) presenting to the East Midlands Sarcoma Service.

Method

Methods: Patients were identified from a histopathology database and spanned a 28-year period. A retrospective case note analysis was undertaken for those patients identified as Solitary Fibrous Tumours on the database.

Results

Results: Between the years of 1988 and 2016, 234 samples in 187 patients were identified of which 95 were male and 92 were female. The mean age was 56.5 years (range 10 to 92 years). In total, 59 of the tumours were located in the head and neck, 71 were thoracic and the remainder extra thoracic. 15 patients (8.0%) developed local recurrence and 9 patients (4.8%) developed metastases. Of the 9 patients with metastases, 2 had metastasized from head and neck primaries, 4 from thoracic primaries and 3 from extrathoracic primaries.   The median time from primary to local recurrence was 61 months whilst the median time from primary to metastatic disease was just 11 months.

Conclusion

Conclusion: Solitary fibrous tumours are rare sarcomas and can occur in a variety of distinct anatomical sites. Local recurrence and metastases occurred in our series at a rate of 8.0% and 4.8% respectively and predominantly in the thoracic and head and neck SFT’s.