Patient recruitment for observational and interventional research studies in anal cancer in Leeds, England for 2013-2018
Session type: Poster / e-Poster / Silent Theatre session
Anal cancer is rare but its incidence is rising with around 1,200 people diagnosed per year in the UK. In colorectal cancer, sustained patient participation rates of ≥16% in interventional research studies is associated with improved survival for the whole patient population. We evaluate recruitment for the non-surgical management of anal cancer with regards to trial type and proportion of patients recruited.
Study recruitment data was searched on electronic medical records for all patients with a new diagnosis of anal cancer who had radical treatment 01/01/13-31/12/18.
Table 1 shows number of patients approached and entered for observational and interventional trials split by year of diagnosis. This shows a decline in recruitment for observational studies and an increase in recruitment for interventional studies over time. Total number approached and proportion of approached that entered an interventional study improved over time. 44 patients over the 6 year period were approached and/or entered more than 1 observational trial. No patients were involved in >1 interventional trial. In 2017-2018, 30% of incident patients entered an interventional trial.
Number of new diagnosis
Table 1 - Anal cancer data 2013-2018 split by trial type and recruitment status
*Large recruitment for 2014 is due to a patient-reported outcome study that recruited patients who were post treatment (including those diagnosed pre-2014)
Overall recruitment, proportion of patients approached and proportion of those approached that entered an interventional study improved overtime. We have demonstrated that high participation rates in interventional trials of a rare cancer is possible and aim to sustain and increase our recruitment in the future.