Peripheral Neuropathy (PN) during and 12 months after Capecitabine and Oxaliplatin chemotherapy (CAPOX) for colorectal cancer


Session type:

Dawn Storey1, Maria Sakala2, Sally Clive2

1University of Edinburgh Cancer Research Centre, UK, 2Edinburgh Cancer Centre, UK


There is little data regarding PN during and after CAPOX and speculation that it may be more common than with FOLFOX4 (5-Fluorouracil and Oxaliplatin 85mg/m2, d1, q14). We aimed to determine the incidence and associations of acute PN during CAPOX and chronic PN 6 and 12 months afterwards.

A retrospective audit of 188 Oxaliplatin nave colorectal cancer patients (87 adjuvant, 101 palliative) who received at least one cycle of CAPOX (Oxaliplatin 130mg/m2 over 2 hours, d1, q21 and Capecitabine 1000mg/m2 orally twice daily day 1 evening to day 15 morning for 8