Radiogenomics Consortium meta-analysis of four genome wide association studies of late toxicity after radiotherapy for prostate cancer


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Catharine West1, Gill Barnett2, Sarah Kerns3, Laura Fachal4, Neil Burnet2, Alison Dunning5, Antonio Gómez-Caamaño6, Harry Ostrer7, Paul Pharoah5, Barry Rosenstein3, Ana Vega4, Matt Parliament8
1University of Manchester, Manchester, UK,2Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK,3Icahn School of Medicine at Mount Sinai, New York, USA,4Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain,5University of Cambridge, Cambridge, UK,6Complexo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain,7Albert Einstein College of Medicine, New York, USA,8Cross Cancer Institute, Alberta, Canada

Abstract

Background

Studies are attempting to identify common genetic variants (single nucleotide polymorphisms, SNPs) that increase a cancer patient's risk of radiotherapy toxicity.  To date few positive associations were replicated due to insufficient statistical power. Therefore, a meta-analysis was performed on existing genome wide association studies (GWAS).