Radium 223 – Early Beatson Experience
Session type: Proffered paper sessions
Radium 223 treatment for bony only metastatic disease from metastatic castrate resistant prostate cancer (mCRPC) has been available only in England through the Cancer Drugs Fund (CDF) which cease later following the delisting by the CDF. Radium 223 received approval from Scottish Medicines Consortium (SMC) on 13 October 2015. Beatson West of Scotland Cancer Centre started delivering Radium 223 treatment in May 2016 to mCRPC. We share our early experience within clinical service context.
We collected data on the 18 patients with metastatic prostate cancer who had completed all 6 cycles of Radium 223 treatment including background information of initial PSA (iPSA) at diagnosis, clinical trials participation prior to treatment, types of first , second and third line treatment received, if palliative radiotherapy was delivered within 12 weeks prior to Radium 223 treatment, prior treatment with bisphosphonates, median time from the last Radium223 treatment to time of death and reasons for stopping treatment.
Majority had iPSA of less than 50, 5 patients had been involved with clinical trials prior, majority received prior Docetaxel treatment as first line and Enzalutamide as second line therapy, 5 patients who needed palliative radiotherapy within 12 weeks prior and 7 patients received bisphosphonates prior to palliative radiotherapy.
Mean survival was 45 days from the end of Radium223 treatment to time of death and 9 patients completed all 6 cycles of treatments successfully.
Our early experience with Radium 223 treatment post marketing indicates that this is feasible option. However we have not yet replicated the ALSYMPCA trial results in our experience. We postulate that this is either due to patient selection, long waiting time from suitability to Radium223 and the treatment to become available in our centre.
We are in the process of analysis the full one year results and will be updating in future conferences