Randomised phase 3 study of panitumumab with FOLFOX compared to FOLFOX alone as 1st line treatment (tx) for metastatic colorectal cancer (mCRC): the PRIME trial
Session type: Poster / e-Poster / Silent Theatre session
1Beatson Cancer Centre, Glasgow, UK, 2Centre Ren Gauducheau, Nantes, France, 3Ospedale Niguarda Ca Granda, Milan, Italy, 4Vall d'Hebrn University Hospital, Barcelona, Spain, 5Mount Sinai Hospital, Toronto, Canada, 6Hospital de Gastroenterologa, Buenos Aires, Argentina, 7Centre du Cancer de l'Universit Catholique de Louvain, Brussels, Belgium, 8The Royal Marsden NHS Foundation Trust, London, UK, 9Amgen Inc, California, USA
Panitumumab (pmab) is a fully human anti-epidermal growth factor receptor monoclonal antibody approved as monotherapy for patients (pts) with mCRC. The PRIME trial was designed to evaluate the efficacy and safety of pmab with FOLFOX vs FOLFOX alone as 1st-line tx for mCRC according to tumour KRAS mutational status (clinicaltrials.gov identifier: NCT00364013; sponsor: Amgen Inc).
This was a randomised, multicenter, phase 3 study. Pts were randomised 1:1 to receive pmab 6.0 mg/kg Q2W+FOLFOX (Arm 1) vs FOLFOX alone (Arm 2).