Role of TGF-beta in glioblastoma
Session type: Oral
Theme: Invited speaker abstract
During the last decades, the TGF pathway has emerged as a therapeutic target againstcancer. However, TGF has a complex role in cancer. During tumour progression TGFbecomes an oncogenic factor inducing proliferation, angiogenesis, invasion, andmetastasis, as well as suppressing the anti-tumoral immune response. The preciseunderstanding of the role of TGF in oncogenesis is required in order to design optimaltherapeutic approaches and select the patient population that may benefit from an anti-TGF therapy. I will present our work related to the role of TGF in glioblastomafocusing on the impact of TGF on the tumour microenvironment. Our works aims atproviding biomarkers of response to TGF signalling inhibitors through theunderstanding of the TGF oncogenic response in glioblastoma.