Small molecule inhibitors of the transmembrane receptor tyrosine kinase Axl as potential anti-cancer therapeutics

Year: 2009

Session type: Poster / e-Poster / Silent Theatre session

Azadeh Bagherzadeh¹, Neil Jones¹, Michelle Barnard¹, Alexandra Boakes¹, Timo Heikkila¹, James Firth¹, Gregoire Pave¹, Emma Wynne¹, Francesca Blum¹, Irene Farr Gutierrez¹, Kevin Stewart¹, Aurore Lejeune¹, Tim Hammonds¹, Alan Storey³, Edel OToole², Lorna Stewart¹, Laurent Rigoreau¹

¹Cancer Research Technology Discovery Lab, London, UK, ²Barts and London School of Medicine and Dentistry, Queen Mary, University of London, UK, ³Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK

Abstract

Following stimulation by its endogenous ligand Gas6, the transmembrane receptor tyrosine kinase (RTK) Axl mediates oncogenic transformation through its intracellular kinase domain (ICD).

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NCRI Cancer Conference abstracts

Abstracts from the NCRI Cancer Conferences

Small molecule inhibitors of the transmembrane receptor tyrosine kinase Axl as potential anti-cancer therapeutics

Azadeh Bagherzadeh¹, Neil Jones¹, Michelle Barnard¹, Alexandra Boakes¹, Timo Heikkila¹, James Firth¹, Gregoire Pave¹, Emma Wynne¹, Francesca Blum¹, Irene Farr Gutierrez¹, Kevin Stewart¹, Aurore Lejeune¹, Tim Hammonds¹, Alan Storey³, Edel OToole², Lorna Stewart¹, Laurent Rigoreau¹

¹Cancer Research Technology Discovery Lab, London, UK, ²Barts and London School of Medicine and Dentistry, Queen Mary, University of London, UK, ³Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK

Abstract

Small molecule inhibitors of the transmembrane receptor tyrosine kinase Axl as potential anti-cancer therapeutics

Azadeh Bagherzadeh1, Neil Jones1, Michelle Barnard1, Alexandra Boakes1, Timo Heikkila1, James Firth1, Gregoire Pave1, Emma Wynne1, Francesca Blum1, Irene Farr Gutierrez1, Kevin Stewart1, Aurore Lejeune1, Tim Hammonds1, Alan Storey3, Edel OToole2, Lorna Stewart1, Laurent Rigoreau1

1Cancer Research Technology Discovery Lab, London, UK, 2Barts and London School of Medicine and Dentistry, Queen Mary, University of London, UK, 3Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK

Abstract

Azadeh Bagherzadeh¹, Neil Jones¹, Michelle Barnard¹, Alexandra Boakes¹, Timo Heikkila¹, James Firth¹, Gregoire Pave¹, Emma Wynne¹, Francesca Blum¹, Irene Farr Gutierrez¹, Kevin Stewart¹, Aurore Lejeune¹, Tim Hammonds¹, Alan Storey³, Edel OToole², Lorna Stewart¹, Laurent Rigoreau¹

¹Cancer Research Technology Discovery Lab, London, UK, ²Barts and London School of Medicine and Dentistry, Queen Mary, University of London, UK, ³Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK