The oncological safety of nipple sparing mastectomy: The European INSPIRE Project


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Isabel Rubio1
1Hospital Universitario Vall d´Hebron

Abstract

Nipple Sparing Mastectomy (NSM) entails the conservation of the nipple–areola complex (NAC) as well as the skin envelope while performing a complete excision of all the mammary gland. NSM and immediate breast reconstruction has been practiced more and more often in the last decade in treating invasive and in situ breast cancer and for women with an increased risk of developing breast cancer. One significant advantage of the NSM technique is the removal of the whole breast tissue while preserving native breast integrity, the nipple-areola complex as well as the submammary fold, therefore improving the cosmetic outcomes.

As rates of NSM continue to increase, it is important to retrieve confirmatory evidence in support of the oncologic safety of the technique. To test the effectiveness and safety of NSM, a large prospective data collection has been set, the INSPIRE project. The INSPIRE project aims to gain insight in treatment strategies for women undergoing NSM and immediate breast reconstruction for breast cancer or for risk reducing purposes. The target is to provide prospective robust evidence on its oncological safety; complications (associated risks of nipple and skin necrosis, infection rates, reconstruction loss, nipple symmetry) and patient reported outcome measures (PROMs).