Tumour-size as a surrogate for overall survival in advanced colorectal cancer


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Tomasz Burzykowski1
1Hasselt University

Abstract

It has been shown (for instance, in metastatic breast cancer or advanced colorectal cancer) that tumour response is not a valid surrogate for overall survival. However, tumour response is a binary endpoint and it ignores information contained in the change in tumour size, upon which it is based. Thus, one can ask question whether change in tumour size might be a better candidate for a surrogate for overall survival. In the presentation we will present results of an analysis aiming at answering this question using a database of clinical trials in colorectal cancer.