¹University of Hull, Hull, UK

¹The Institute of Cancer Research, London, UK,²Royal Marsden Hospital, London, UK

¹Flinders University, Adelaide, Australia

¹Cancer Research UK, London, UK,²University of Stirling, Stirling, UK

¹Queen Mary University of London, London, UK

¹Univeristy of Cambridge, Cambridge, UK

¹Icahn School of Medicine at Mount Sinai, New York NY, USA

¹Memorial Sloan Kettering Cancer Center, New York, NY, USA

¹Medical University of Graz, Graz, Austria

¹University of Cambridge, Cambridge, UK

¹University of Groningen, Groningen, The Netherlands

¹MRC Toxicology Unit, Leicester, UK

¹CRUK Centre for Drug Development, London, UK

¹UCL, London, UK

¹AstraZeneca Oncology Innovative Medicines, Cambridge, UK

¹University of Leicester, Leicester, UK

¹WCRF International, London, UK,²University of Southampton, Southampton, UK

¹Institute of Cancer Research, Sutton, Surrey, UK

¹Genome Damage and Stability Centre, Falmer, Brighton, UK

¹German Cancer Research Centre (DKFZ), Heidelberg, Germany

¹University of Birmingham, West Midlands, UK

¹BC Cancer Agency Research Centre, Vancouver, BC, Canada,²University of British Columbia, Vancouver, BC, Canada

¹University of Exeter, Exeter, UK

¹University of California, San Francisco, San Francisco, CA, USA,²Harvard School of Public Health, Boston, MA, USA

¹Bangor University, Bangor, UK

¹Flatiron Health, New York, NY, USA

¹Dept. of Oncology, University Hospital of Lausanne, Lausanne, Switzerland,²Ludwig Cancer Research Center, Lausanne, Switzerland

¹University of Cambridge, Cambridge, UK

¹Ontario Institute for Cancer Research, Toronto, Canada,²University of Toronto, Toronto, Canada

¹University of Twente, Enschede, The Netherlands

¹University of Oxford, Oxford, UK

¹Division of Genetics & Epidemiology, Institute of Cancer Research, London, UK,²Verna & Marrs McLean Dept. of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA,³Dept of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA,⁴Our Lady’s Children’s Hospital, Dublin, UK,⁵Wake Forest University School of Medicine, Winston-Salem, USA,⁶Public Health England, Oxford, UK,⁷Dept of Histopathology and Paediatric Laboratory Medicine, Great Ormond Street Hospital, London, UK,⁸Cancer Genetics Unit, Royal Marsden Hospital NHS Foundation Trust, London, UK

¹Institute of Cancer Sciences, University of Manchester, Manchester, UK,²Institute of Population Health, University of Mancchester, Manchester, UK,³Department of Obstetrics and Gynaecology, University of Aberdeen, Aberdeen, UK

¹Northern Centre for Cancer Care, Newcastle upon Tyne, UK,²MRC Clinical Trials Unit at UCL, London, UK,³Castle Hill Hospital, East Yorkshire, UK,⁴The Christie, Manchester, UK,⁵Bristol Haematology & Oncology Centre, Bristol, UK,⁶University Hospital Llandough, South Glamorgan, UK,⁷Royal Victoria Infirmary, Newcastle upon Tyne, UK,⁸Beatson West of Scotland Cancer Centre, Glasgow, UK,⁹Mater Hospital, Brisbane, Queensland, Australia,¹⁰Nottingham University Hospitals, Nottingham, UK,¹¹Weston Park Hospital, Sheffield, UK,¹²Queen Elizabeth Hospital, King’s Lynn, UK

¹The Institute of Cancer Research, London, UK,²Clatterbridge Cancer Centre, Wirral, UK,³Velindre Cancer Centre, Cardiff, UK,⁴Ipswich Hospital, Ipswich, UK,⁵Lincoln County Hospital, Lincoln, UK,⁶Royal Surrey County Hospital, Guildford, UK,⁷Christie Hospital, Manchester, UK,⁸Royal Marsden NHS Trust, London, UK,⁹Musgrove Park Hospital, Taunton, UK,¹⁰Royal Sussex County Hospital, Brighton, UK,¹¹Royal Preston Hospital, Preston, UK

¹The Christie NHS Foundation Trust, Manchester, UK,²National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan,³National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan,⁴HonorHealth, Scottsdale, AZ, USA,⁵TGen, Scottsdale, AZ, USA,⁶Taipei Veterans General Hospital, Taipei, Taiwan,⁷National Yang-Ming University, Taipei, Taiwan,⁸Washington University in St. Louis, St. Louis, MO, USA,⁹St László Teaching Hospital, Budapest, Hungary,¹⁰St John of God Hospital, Subiaco, Western Australia, Australia,¹¹Scottsdale Healthcare, Scottsdale, AZ, USA,¹²Vall d’Hebron University Hospital, Barcelona, Spain,¹³Vall d’Hebron Institute of Oncology, Barcelona, Spain,¹⁴Seoul National University Hospital, Seoul, Republic of Korea,¹⁵Hôpital Saint-André, Bordeaux, France,¹⁶China Medical University Hospital, Taichung, Taiwan,¹⁷Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil,¹⁸Klinikum rechts der Isar der TU München, Munich, Germany,¹⁹Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA

¹MD Anderson Cancer Center, University of Texas, Houston, TX, USA,²Institut Gustave Roussy, Villejuif, France,³Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, Boston, MA, USA,⁴Roswell Park Cancer Institute, Buffalo, NY, USA,⁵Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA,⁶Stanford Cancer Institute, Stanford, CA, USA,⁷University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA,⁸Vanderbilt University Medical Center, Nashville, TN, USA,⁹Fondazione Istituto Nazionale Tumori, Milan, Italy,¹⁰Fox Chase Cancer Center, Philadelphia, PA, USA,¹¹Hospital Universitario 12 De Octubre, Madrid, Spain,¹²Westmead Hospital, New South Wales, Australia,¹³Aarhus University Hospital, Aarhus, Denmark,¹⁴Comprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland,¹⁵South West Wales Cancer Institute and Swansea University College of Medicine, Swansea, UK,¹⁶University Hospital Essen of University of Duisburg-Essen, Essen, Germany,¹⁷Chiba Cancer Center, Chiba, Japan,¹⁸Bristol-Myers Squibb, Hopewell, NJ, USA,¹⁹Bristol-Myers Squibb, Lawrenceville, NJ, USA

¹University of Cambridge School of Clinical Medicine, Cambridge, UK,²Macmillan Cancer Support, London, UK,³Coventry University, Coventry, UK,⁴Addenbrooke’s Cambridge University Hospitals NHS Trust, Cambridge, UK,⁵Bedford Hospital NHS Trust, Bedford, UK

¹National Cancer Registry Ireland, Cork, Ireland,²Trinity College Dublin, Dublin, Ireland,³Newcastle University, Newcastle, UK

¹ICR, LONDON, UK,²UCSF, SAN FRANCISCO, USA

¹Warwick Clinical Trials Unit, Coventry, UK,²South Devon Healthcare NHS Foundation Trust, Torquay, UK,³Independent Cancer Patient Voices, London, UK,⁴Department of Clinical Healthcare, Oxford Brookes University, Oxford, UK,⁵St James’s University Hospital, Leeds, UK,⁶University Hospital of South Manchester NHS Foundation Trust, Manchester, UK,⁷Ninewells Medical School, Dundee, UK

¹Department of Cancer Studies and Cancer Research UK Leicester Centre, Leicester, UK,²Imperial College, Department of Surgery and Cancer, Charing Cross Hospital, London, UK,³Silicon Biosystems, Bologna, Italy

¹Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK,²Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK,³Cehmical Genomics Group, RIKEN Center for Sustainable Resource Science, Wako, Japan

¹University of Southampton, Southampton, UK,²University of Portsmouth, Portsmouth, UK,³St. George’s University Hospitals, London, UK,⁴Poole Hospital NHS Foundation Trust, Poole, UK

¹Wellcome Trust Sanger Institute, Hinxton, UK,²Harvard Medical School, Boston, UK,³University of Tampere and Fimlab Laboratories, Tampere, Finland,⁴University College London, London, UK

¹Cancer Research UK, London, UK,²Cancer Research UK Cambridge Institute, Cambridge, UK,³Institute of Medical Genetics, Cardiff, UK,⁴University of Oxford, Oxford, UK,⁵The Centre for Molecular Pathology, Surrey, UK,⁶West Midlands Regional Genetics Laboratory, Birmingham, UK,⁷Leeds Institute of Cancer and Pathology, Leeds, UK,⁸University of St. Andrews, St. Andrews, UK,⁹The Royal Marsden NHS Foundation Trust, London, UK,¹⁰Cardiff University, Cardiff, UK,¹¹The Queen Elizabeth Hospital, Birmingham, UK,¹²Royal Brompton and Harefield Hospitals NHS Foundation Trust, London, UK,¹³NHS Greater Glasgow and Clyde, Glasgow, UK,¹⁴Papworth Hospital NHS Foundation Trust, Cambridge, UK,¹⁵Manchester Cancer Research Centre, Manchester, UK

¹Imperial College, London, UK,²Waters Corporation, Budapest, Hungary

¹UCL, London, UK

¹UCL, London, UK,²QMUL, London, UK,³University of Exeter, Exeter, UK,⁴London Borough of Waltham Forest, London, UK

¹University College London, London, UK,²University of Oxford, Oxford, UK,³Imperial College London, London, UK,⁴King’s College London, London, UK,⁵Great Ormond Street Hospital, London, UK