466 abstracts found.



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The impact of the COVID-19 pandemic on cancer diagnostic pathways in children, teenagers and young adults: a cohort study in England

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Defne Saatci1, Jason Oke1, Anthony Harnden1, Julia Hippisley-Cox1
1University of Oxford

Molecular screening of urine for Mismatch Repair deficient urothelial tumours; an under-appreciated cancer in Lynch syndrome

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Rachel Phelps1, John Burn1, Christine Hayes1, Richard Gallon1, Jo Pethick2, Fiona McRonald2, Steven Hardy2, Peter Gawthorpe1, Gillian Borthwick1, Mauro Santibanez-Koref1, Michael Jackson1
1Newcastle University, 2Public Health England

A global review of publicly available open-access skin cancer image datasets used in development of machine learning algorithms for skin cancer diagnosis

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David Wen1, Saad Khan2, Antonio Ji-Xu3, Hussein Ibrahim4, Luke Smith5, Jose Cabellero5, Luis Zepeda5, Les Mara5, Alastair Denniston1, Xiaoxuan Liu1, Rubeta Matin3
1University of Birmingham, 2Royal Berkshire NHS Foundation Trust, 3Oxford University Hospitals NHS Foundation Trust, 4University Hospitals Birmingham NHS Foundation Trust, 5Other

Circulating Tumour Cell Analysis to Evaluate Docetaxel Treatment Response and Resistance Markers in Prostate Cancer

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Caitlin Davies1
1Barts Cancer Institute

The influence of ethnicity on survival in malignant brain tumours in England: a population-based cohort study

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Hiba Wanis1, Elizabeth Davies1, Henrik Møller1, Keyoumars Ashkan1
1King’s College London (KCL)

Evaluation of a hypoxia-associated gene signature in the NIMRAD trial that randomised head and neck cancer patients to radiotherapy alone or with nimorazole 

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Joely Irlam1, Elisabet More1, Guy Betts2, Nick Slevin3, David Thomson3, Ananya Choudhury1, Catharine West1
1University of Manchester, 2Manchester University Hospitals NHS Foundation Trust, 3Other

The spatial landscape of clonal expansion by confined somatic mutations in benign and malignant tissue

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Alastair Lamb1, Andrew Erickson2, Emelie Berglund3, Mengxiao He3, Joakim Lundberg3
1University of Oxford, 2Nuffied Department of Surgical Sciences, 3Other

Preventing weight gain to prevent breast cancer

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Mary Pegington1, Michelle Harvie2, Alan Davies1, David French1, Julia Mueller3, Anthony Howell1
1University of Manchester, 2Manchester University Hospitals NHS Foundation Trust, 3University of Cambridge

Macrophage Polarization in Pembrolizumab Induced Mycobacterium Tuberculosis Granuloma Formation in Nasopharyngeal Carcinoma

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Tae Yang Desmond Hung1, Ngar Woon Kam1, Victor Ho Fun Lee1
1University of Hong Kong

Patient and informal carers experience of living with mesothelioma: A systematic rapid review and synthesis of the literature

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Stephanie Ejegi-Memeh1, Virginia Sherborne1, Madeleine Harrison1, Bethany Taylor1, Michaela Senek1, Angela Tod1, Clare Gardiner1
1University of Sheffield

DEPEND – early identification of pancreatic cancer using pancreatic exocrine insufficiency and faecal elastase as screening tools

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Declan McDonnell1, Paul Afolabi1, Christopher Byrne1, Sam Wilding2, Victoria Goss2, Zaed Hamady1
1University Hospital Southampton NHS Foundation Trust, 2University of Southampton

Prostate cancer progression is driven by adipocyte-derived extracellular vesicles

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Fabrizio Fontana1, Monica Marzagalli1, Michela Raimondi1, Emanuela Carollo2, Patrizia Sartori1, Patrizia Procacci1, David Carter2, Patrizia Limonta1
1University of Milan, 2Oxford Brookes University

The effect of the COVID-19 pandemic on the functional capacity and cardiopulmonary fitness of major surgery patients.

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Miranda Bowman1, Rhona Sinclair2, Alastair Greystoke1
1Newcastle University, 2Newcastle upon Tyne Hospitals NHS Foundation Trust

Impact of COVID – 19 pandemic on psycho-social well-being of cancer patients attending Dubai Hospital.

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Kaltar Das1, Muhammad Farooq Latif1, Syed Hamad Tirmazy1, Nezar Salim1, Shila Sajan1, Susheel Kumar1, Abdul Basit1, Mohamed Omara1, Dalia El shourbagy1, Dina Hamza1, Jessy A Thomas1
1Dubai Health Authority

Adjuvant immunotherapy (IO) or targeted treatment (TT) in fully resected Stage III and IV melanoma patients: Single centre analysis.

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Lani Walshaw1, Peter Wilson1, Abolore Amuludun1, Donna Wynter1, Sukaina Rashid1, Shanthini Crusz1
1St Bartholomew’s Hospital

A dynamic prediction model for early detection of colorectal cancer using routine blood test results from primary care

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Pradeep S. Virdee1, Jacqueline Birks2, Tim Holt2
1Centre for Statistics in Medicine, University of Oxford, 2University of Oxford

Treatment outcomes of patients with cutaneous melanoma harbouring rare BRAF mutations

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Tamsin Nash1, Pavlina Spiliopoulou1, Yun Yi Tan1, Jeff Evans2, Ashita Waterston1
1Beatson West of Scotland Cancer Centre, 2University of Glasgow

Delayed immune-related adverse events (irAE) with anti-PD1-based immunotherapy in melanoma

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Carina Owen1
1University Hospitals Bristol NHS Foundation Trust

Identification of symptoms associated with the diagnosis of pancreatic exocrine and neuroendocrine neoplasms: a nested case-control study of the UK population

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Weiqi Liao1, Ashley Clift1, Martina Patone1, Carol Coupland2, Stephen P Pereira3, Julia Hippisley-Cox1
1University of Oxford, 2University of Nottingham, 3University College London (UCL)

Palliative healthcare professionals give greater weight to advice from a prognostic algorithm rather than advice from another healthcare professional when predicting 2-week survival: the ADJUST study

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Andrea Bruun1, Nicola White1, Linda Oostendorp1, Victoria Vickerstaff1, Adam Harris1, Christopher Tomlinson2, Steven Bloch1, Patrick Stone1
1University College London (UCL), 2Imperial College London

Management of adverse events in patients with HER2+ metastatic breast cancer treated with tucatinib, trastuzumab, and capecitabine (HER2CLIMB)

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Alicia Okines1, Elisavet Paplomata2, Tanya Wahl2, Gail Wright2, Stephanie Sutherland3, Erik Jakobsen2, Frances Valdes-Albini2, Arlene Chan2, Amy Clark4, Alison Conlin2, Maryam Lustberg2, Jennifer Specht2, Timothy Pluard2, Xiaofu Zhu2, Ian Krop5, Karen Gelmon6, Dennis Slamon2, Jorge Ramos2, Wentao Feng2, Erika Hamilton2
1Royal Marsden NHS Foundation Trust, 2Other, 3Mount Vernon Cancer Centre, 4University of Pennsylvania, 5Dana-Farber Cancer Institute, 6BC Cancer Agency

The immune infiltrate, TGFb signalling and APC mutation determine complete response to radiation in rectal cancer

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Enric Domingo1, Sanjay Rathee2, Andrew Blake2, Leslie Samuel3, Graeme Murray4, David Sebag-Montefiore5, Simon Gollins6, Nicholas West5, Rubina Begum7, Marian Duggan7, Laura White7, Sylvana Hassanieh2, Susan Richman5, Phil Quirke5, James Robineau2, Keara Redmond8, Aikaterini Chatzipli9, Ultan McDermott9, Viktor Koelzer10, Simon Leedham2, Ian Tomlinson11, Philip Dunne8, Francesca Buffa2, Tim Maughan2
1University of Oxford, Oxford, UK, 2University of Oxford, 3NHS Grampian – Aberdeen Royal Infirmary, 4University of Aberdeen, 5University of Leeds, 6North Wales Cancer Treatment Centre, 7University College London (UCL), 8Queen’s University Belfast, 9Wellcome Sanger Institute, 10University of Zurich, 11University of Edinburgh

A novel mechanism promotes actin patch formation to prevent chromatin bridge breakage in cytokinesis

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Sofia Balafouti1, George Zachos1, Eleni Petsalaki1
1Other

Evaluation of a faith-placed education intervention for bowel cancer screening in Muslim communities in the East of England

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Marimba Carr1, Daksha Trivedi2, Claire Thompson2, Nigel Smeeton2, Salman Waqar3, Tara Berger Gillam4, Iffat Tejani5
1NHS England, 2University of Hertfordshire, 3University of Oxford, 4Public Health England, 5No affiliation

Improving cancer care efficiency in Covid-19 recovery: A service improvement project establishing an Emergency Ambulatory Acute Oncology Service

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Charlotte Maden1, Alison Hodge2, David Bloomfield2
1University Hospitals Sussex, 2Brighton and Sussex University Hospitals NHS Trust

Enablers of Home-based Physical Activity for People with Lung Cancer and Cachexia

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Nichola Gale1, Jane Hopkinson2, David Wasley3, Anthony Byrne4
1Cariff University, 2Cardiff University, 3Cardiff Metropolitan University, 4Cardiff and Vale University Health Board (CVUHB)

Exploring complexity in international primary care referral pathways for the management of suspected cancer

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Charlotte Lynch1, Brian Nicholson2, Cathy Clelland3, May-Lill Johansen4, Jon Emery5, Ross Lawrenson3, David Weller6, Claire Collins3, Dorte Ejg Jarbol7, Kirubakaran Balasubramaniam7, Alun Surgey8, Laurence Dorman3, Samantha Harrison9
1Cancer Research UK, London, UK, 2University of Oxford, 3Other, 4UiT The Arctic University of Norway, 5University of Melbourne, 6University of Edinburgh, 7University of Southern Denmark, 8Bangor University, 9Cancer Research UK (CRUK)

Myoferlin: A predictive marker of response to radiotherapy and survival in patients with locally advanced rectal cancer and a poteintal therapeutic target

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Hayley Fowler1, Rachael Clifford1, David Bowden1, Paul Sutton1, Naren Govindarajah1, Matthew Fok1, Jason Parsons1, Dale Vimalachandran2
1University of Liverpool, 2Countess of Chester Hospital NHS Foundation Trust

Novel platinum(II)-containing compounds as potent, mono- or combination therapies to combat resistance in GI cancers

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Katie Lloyd1, Emma Haynes1, Gabriele Wagner1
1University of Chester

Real world outcomes in cancer patients with COVID-19 infection: Northern Ireland experience.

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Laura Feeney1, Anita Lavery2, Ashleigh Hamilton2, Conor O’Neill2, Gerard Walls3, Kirsty Taylor2, Richard Turkington4
1CCRCB Queens University Belfast, 2Northern Ireland Cancer Centre, 3Northern Centre for Cancer Care, 4Queen’s University Belfast

Adoption of a DPYD variant screening panel and treatment dosing protocol in South East London Cancer patients undergoing fluoropyrimidine chemotherapy is workable safe and effective.

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Julien de Naurois1, Kalliopi Michoglou1, Dimity Ball1, Muhammad Khan1, Ketevan Eremeishvili1, Jose Roca1, Asad Qureshi1, Nick Maisey1, Kiruthikah Thillai1, Miguel Reis Ferreira1, Sarah Ngan1, Kasia Owczarczyk1, Debashis Sarker1, Ailsa Sita-Lumsden1, Vasiliki Michalarea1, Jessica Brady1, Irene DeFrancesco1, Tony Marinaki1, Paul Ross1
1Guy’s and St Thomas’ NHS Foundation Trust

Is there a weekend effect in colonoscopy? A population-based study using the National Endoscopy Database

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Linda Sharp1, Liya Lu1, Jamie Catlow2, Raphael Broughton3, Peter Rogers4
1Newcastle University, 2North Tees & Hartlepool NHS Foundation Trust, 3Royal College of Physicians (RCP), 4Other

Investigating the multi-modality anti-tumour effects of combined sequential tumour irradiation and vascular-targeted photodynamic therapy in preclinical prostate cancer.

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Richard Bryant1, Hanna Sjoberg2, Yiannis Philippou2, Anette Magnussen2, Iain Tullis2, Esther Bridges2, Andrea Chatrian1, Joel Lefebvre1, Ka Ho Tam1, Emma Murphy2, Jens Rittscher1, Dina Preise3, Lilach Agemy3, Tamar Yechezkel3, Sean Smart2, Danny Allen2, David Scheiblin4, Stephen Lockett4, David Wink4, Alastair Lamb2, Ian Mills2, Adrian Harris2, Ruth Muschel2, Boris Vojnovic2, Avigdor Scherz3, Freddie Hamdy2
1University of Oxford, 2Cancer Research UK (CRUK) Oxford Centre, 3Weizmann Institute of Science, 4National Institutes of Health (NIH)

Hormone Replacement Therapy and Cancer Survival: A Longitudinal Cohort Study

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Tom Ranger1, Judith Burchardt1, Ashley Clift1, Winnie Mei1, Carol Coupland2, Pui San Tan1, Sharon Dixon1, Alexander Labeit3, Christopher Cardwell3, Julia Hippisley-Cox1
1University of Oxford, 2University of Nottingham, 3Queen’s University Belfast

A new England-wide survey on quality of life after cancer

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Charlotte Judge1, Clare Frobisher1, Carolynn Gildea1, Roger Hill1, Kerry Hibberd2, Lucinda Phillips2, Daniel Ratchford2, Val Shilling3, Gillian Rosenberg3, Alice Simon3, Simon Rogers4
1Public Health England, 2Other, 3NHS England, 4Edge Hill University

Efficacy and safety of avelumab + axitinib (A+Ax) vs sunitinib (S) in elderly patients with advanced renal cell carcinoma (aRCC): extended follow-up results from JAVELIN Renal 101

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Yoshihiko Tomita1, Anand Sharma2, Robert Motzer3, Toni Choueiri1, Brian Rini4, Hideaki Miyake1, Hirotsugu Uemura1, Laurence Albiges1, Yosuke Fujii1, Yoshiko Umeyama1, Jing Wang5, Mariangela Mariani1, Manuela Schmidinger1
1Other, 2Mount Vernon Cancer Centre, 3Memorial Sloan-Kettering Cancer Center, 4Vanderbilt-Ingram Cancer Center, 5Pfizer

Endoscopically-delivered Purastat for the treatment of severe haemorrhagic radiation proctopathy: A case series

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Katherine White1, Caroline Henson1
1Manchester University Hospitals NHS Foundation Trust

An ex vivo functional assay suite determines that ovarian tumour DNA damage response pathway signatures are heterogeneous and classify patient outcomes in ovarian cancer

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Thomas Walker1, Zahra Faraahi1, Marcus Price1, Amy Hawarden1, Dominique Jones1, Aiste McCormick2, Laura Woodhouse2, Connor Roberts1, Emma Crosbie1, Stephen Taylor1, Richard Edmondson1
1University of Manchester, 2Newcastle University

Brain metastases in renal cell carcinoma. A 10-year retrospective study from a West Midlands tertiary centre

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Peijing Teo1, Iskandar Mohamed1, Simon Grumett1
1University Hospitals Birmingham NHS Foundation Trust

Liver x receptor splice variants are prognostic indicators in triple negative breast cancer patients

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Priscilia Lianto1, J. Bernadette Moore1, Thomas A Hughes1, James L Thorne1
1University of Leeds

Continuous physiologic monitoring using wearable sensors of home based cancer patients with COVID-19: RECAP study (NCT04397705)

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Ann Tivey1, Rohan Shotton1, Rachel Oakley2, Sally Taylor1, Tim Cooksley1, Andre Freitas2, David Wong2, Michael King1, John Radford2
1The Christie NHS Foundation Trust, 2University of Manchester

Less chemotherapy for equal survival: the impact of enhanced supportive care in hepatobiliary cancer

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Daniel Monnery1, Sinead Benson1, Helen Wong1, Anna Olsson-Brown1
1Clatterbridge Cancer Centre NHS Foundation Trust

Working together to improve earlier diagnosis of sarcoma

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Victoria Vinader1, Victoria Vinader1, Zoe Davison1, Tobias Firth1, Sorrel Bickley2, Bradley Price2
1Bone Cancer Research Trust, 2Sarcoma UK

Use of pembrolizumab monotherapy for metastatic non-small cell lung cancer expressing PDL1 1-49% in the COVID-19 era

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Grace Tze-en Ding1, Findlay Thomson2, Cory Stratton2, Colin Barrie1, Kirsty Maclennan1, Sorcha Campbell1, Aisha Tufail1, Iain Phillips1, Melanie Mackean1, Mark Stares1
1Edinburgh Cancer Centre, 2University of Edinburgh

Management and Outcomes of confirmed Cancer of Unknown Primary patients referred to the University College London Hospital CUP MDT

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Tharun Joseph Vattam Thottiyil1, Kai-Keen Shiu1
1University College London Hospitals NHS Foundation Trust (UCLH)

The INSPIRE clinical trial – Dosimetry of radioiodine therapy for thyroid cancer patients in the UK

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Jan Taprogge1, Carla Abreu1, Lily Carnegie-Peake1, Paul Gape1, Dominic Rushforth1, Charlotte Barker1, Antigoni Divoli1, Jonathan Gear1, Lucy McAreavey1, Iain Murray1, Brenda Pratt1, Bruno Rojas1, Allison Craig1, Lenka Vavrova1, Kee Howe Wong1, Kate Newbold1, Glenn Flux1
1Royal Marsden NHS Foundation Trust

Use of antiepileptic drugs and risk of prostate cancer: A nationwide case-control study in Prostate Cancer data Base Sweden

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Gincy George1, Gincy George1, Hans Garmo2, Jan Adolfsson3, Lars Holmberg1, Pär Stattin2, Johan Styrke4, Mieke Van Hemelrijck1
1King’s College London (KCL), 2Other, 3Karolinska Institutet, 4Umeå university

Targeting of AKT and Inhibitor of Apoptosis Proteins (IAP) in the treatment of pancreatic ductal adenocarcinoma (PDAC)

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Swati Kumar1, Leanne Stevenson1, Richard C Turkington1
1Queen’s University Belfast

The Scottish Inflammatory Prognostic Score (SIPS) predicts survival with first-line EGFR inhibitors in non-small cell lung cancer

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Amanda Swan1, Kirsten Cumming1, Tze-En Ding1, Colin Barrie1, Kirsty MacLennan1, Sorcha Campbell1, Tamasin Evans1, Aisha Tufail1, Melanie Mackean1, Iain Phillips1, Mark Stares2
1Edinburgh Cancer Centre, 2University of Edinburgh

Adherence to adjuvant endocrine therapy in early breast cancer patients on supported self management: Real world evidence from a cancer unit at a district general hospital

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Sarah Howlett1, May Teoh1
1Royal Surrey NHS Foundation Trust