910 abstracts found.



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Structure-function and structure-inhibition relationships in the CDK family

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Martin Noble

University of Oxford, UK


Addressing delayed cancer diagnosis in primary care: Patterns of attendance and symptoms of teenagers and young adults seen in 3 general practices during 1 year

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Lorna Fern1, Christine Campbell2, Tim Eden3, Robert Grant4, Ian Lewis5, Una McLeod6, David Weller2, Jeremy Whelan1

1University College Hospitals, London, UK, 2University of Edinburgh, Edinburgh, UK, 3University of Manchester, Manchester, UK, 4St Brysdale Surgery, Fife, UK, 5University of Leeds, Leeds, UK, 6University of Glasgow, Glasgow, UK


C-Met oncogenic mutants sustain signals in the endosome and are protected against downregulation

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Carine Joffre, Stephanie Kermorgant

Institute of Cancer and Cancer Research UK Clinical Centre, Bart's and The London School of Medicine and Dentistry, London, UK


Identifying the next generation of anticancer drug targets

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Bob Jackson

Pharmacometrics Ltd, Cambridge, UK


Telomerase-based immunotherapy of cancer

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Robert Vonderheide

University of Pennsylvania, Philadelphia, USA


Cross talk between the VEGF and Notch signalling pathways in endothelial cells

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Laura Harrington, Richard Sainson, Chern Ein Oon, Helen Sheldon, Ji-Liang Li, Adrian Harris

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK


Isoindolinone inhibitors of the MDM2-p53 protein-protein interaction: structure-activity studies

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Anna Watson, Eric Valeur, Bernard Golding, Roger Griffin, Claire Hutton, Jungfeng Liu, Xiaohong Lu, John Lunec, David Newell, Ian Hardcastle

Northern Institute for Cancer Research, Newcastle upon Tyne, UK


DNA fusion gene vaccination, delivered with or without in vivo electroporation – a potent and safe strategy for inducing anti-tumour immune responses in prostate cancer

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Christian Ottensmeier

University of Southampton, UK


Lysyl oxidase secreted by hypoxic tumour cells is critical for pre-metastatic niche formation

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Janine Erler1, Kevin Bennewith2, Amato Giaccia2

1Institute of Cancer Research, London, UK, 2Stanford University, California, USA


A novel small molecule inhibits cancer cell proliferation in vitro and in vivo via activation of the protein kinase AMPK

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Hakim Djeha1, Björn Eriksson2, Thomas Edlund2, Fiona McLaughlin1

1Antisoma Research Ltd, Welwyn Garden City, Herts, UK, 2Betagenon AB, Umeå, Sweden