6719 abstracts found.



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Cancer-induced bone pain: objective functional assessment in relation to palliative radiotherapy

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Angela Boyd1, Barry Laird1, Rory Mitchell1, Susan Fleetwood-Walker1, Hong Wan2, Marie Fallon1, Lesley Colvin1

1University of Edinburgh, Edinburgh, UK, 2Wyeth Research, Collegeville, USA


Cheaper, faster, more powerful imaging-based clinical trials

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Chris Rose1, James O'Connor1, Brandon Whitcher2, Geoff Parker1

1The University of Manchester, Manchester, UK, 2GlaxoSmithKline, London, UK


Methylation profiling identifies over-representation of aberrant methylation of transcriptional activators in chemoresistant ovarian cancer cell lines

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Constanze Zeller, Jens M. Teodoridis, Wei Dai, Janet Graham, Robert Brown

Imperial College, London, UK


The molecular basis of the chemosensitivity of uveal melanoma to treosulfan and gemcitabine

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Rosemary Chalk1, Katherine Parker1, Penny Johnson1, Guy Gabriel1, Sharon Glaysher1, Marta Polak1, Louise A Knight1, Jason Smith1, Jasmine Thombs2, John L Hungerford2, Ian A Cree1

1Cancer Laboratory, Queen Alexandra Hospital, Portsmouth 1Cancer Laboratory, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK, 2Moorfields Eye Hospital and Institute of Opthalmology (UCL), London EC1V 9EL, UK


Biomarkers of response to therapy in gastric/gastro-oesophageal adenocarcinoma

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Khaleel R Fareed1, Mohammed Ilyas2, Philip Kaye3, Irshad Nabi Soomro3, Dileep N Lobo4, Simon L Parsons5, Neil T Welch5, Srinivasan Madhusudan1

1Academic Unit of Oncology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK, 2Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK, 3Department of Pathology, Nottingham University Hospitals, Nottingham, UK, 4Division of Gastrointestinal Surgery, University of Nottingham, Nottingham, UK, 5Department of Surgery, Nottingham University Hospitals, Nottingham, UK


Phenotypic profiling: multiparametric high-content analysis across distinct cancer types

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Neil Carragher, Peter Caie, Alexandra Ingleston-Orme, Sandeep Daya, Rob Eagle, Rebecca Walls, Tom Houslay, Andy Hargreaves

AstraZeneca, Loughborough, Leicestershire, UK


Trial designs to assess biomarkers in clinical practice

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Lucinda Billingham1, Richard Stephens2, Michael Snee3, David Ferry4

1Cancer Research UK Clinical Trials Unit, Birmingham, UK, 2Medical Research Council Clinical Trials Unit, London, UK, 3Cookridge Hospital, Leeds, UK, 4New Cross Hospital, Wolverhampton, UK


The antagonists of chemokine receptor CXCR4 inhibit growth of ovarian cancer cells by inducing mitotic catastrophe and G2/M arrest

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Joseph Kwong1, Hagen Kulbe1, Donald Wong2, Walter Korz2, Fran Balkwill1

1Centre for Cancer and Inflammation, Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, UK, 2Chemokine Therapeutics Corp, Vancouver, Canada


Biomarker analysis of gene-modified T-cells for a CR-UK Phase 1 clinical trial: development and validation of protocols for use in a clinical setting

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Dominic Rothwell, Ryan Guest, David Gilham, Robert Hawkins

University of Manchester, Manchester, UK


Characterisation of ECSM2, a filamin A interacting protein, which modulates endothelial chemotaxis.

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Victoria L Heath1, Laura-Jane Armstrong2, Sharon Sanderson2, Sukhbir Kaur1, James FJ Beesley1, John MJ Herbert1, John A Legg1, Richard Poulsom3, Roy Bicknell1

1Cancer Research UK Angiogenesis Group, The Institute for Biomedical Research, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK, 2Angiogenesis Laboratory, Cancer Research UK, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK, 3Cancer Research UK, The London Research Institute, Lincoln’s Inn Fields, London WC2A 3PX, UK


Co-culture of ovarian cancer cells with macrophages induces expression of a Scavenger Receptor A ligand

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Robin Soper1, Annette Plüddemann2, Subhankar Mukhopadhyay2, Siamon Gordon2, Frances R. Balkwill1, Thorsten Hagemann1

1Centre for Cancer and Inflammation, Institute of Cancer and the Cancer Research UK Clinical Centre, Barts and The London School of Medicine and Dentistry, London, UK, 2Sir William Dunn School of Pathology, University of Oxford, Oxford, UK


Mechanisms of functional interference between HIF-1 and β-catenin in the regulation of carbonic anhyrase-9 (CA9) expression

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Natalie Burrows, Julia Resch, Georg Brabant, Kaye Williams

University of Manchester, Manchester, UK


Nucleolar translocation of NF-κB/RelA and apoptosis as a consequence of proteasome stress

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Hazel Thoms, Carolyn Loveridge, Alexandra Clipson, Karina Reinhardt, Malcolm Dunlop, Lesley Stark

University of Edinburgh, Edinburgh, UK


Radiotherapy fraction size sensitivity modulated by DNA repair systems

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Navita Somaiah1, Kai Rothkamm3, Frances Daley2, Ann Pearson4, Thomas Helleday1, John Yarnold4

1Radiation Oncology and Biology Institute, Oxford, UK, 2Gray Cancer Institute, Northwood, UK, 3Health Protection Agency, Centre for Radiation, Chemical and Environmental Hazards, Chilton, UK, 4Royal Marsden Hospital and Institute of Cancer Research, Sutton, UK


Effects of GnRH receptor activation on proliferation of transformed cells in vitro and in vivo

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Kevin Morgan1, Alan Stewart1, Nicola Miller1, Peter Mullen2, Simon Langdon2, Robert Millar1

1MRC Human Reproductive Sciences Unit, Edinburgh, UK, 2Edinburgh Breakthrough Research Unit, Edinburgh, UK


Network development in biological gels: role in lymphatic vessel development

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Tiina Roose

University of Oxford, Oxford, UK


A real-time imaging analysis of cell death observing caspase activity and propidum iodide accumulation in live cells

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David Jamieson, Jane L Armstrong, Sophie Weatherhead, Trevor R Jackson

Newcastle University, Newcastle upon Tyne, UK


A systems approach reveals a practical, non-toxic and inexpensive method to resolve the tumour microenvironment and potentially turn malignant tumours benign

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Gary Robert Smith

Open University, Milton Keynes, UK


PP2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3

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Sybille Krauss1, John Foerster3, Rainer Schneider2, Susann Schweiger3

1Max-Planck Institute for Molecular Genetics, Berlin, Germany, 2Institute of Biochemistry and Center for Molecular Biosciences, Innsbruck, Austria, 3Ninewells Hospital, Department of Neuroscience and Pathology, Dundee, UK


Can the human minichromosome maintenance proteins form a processive helicase?

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Richard Parker, Rubab Satti, James Chong

University of York, York, UK


Trabectedin (ET-743) is a pro-differentiation drug in myxoid liposarcoma tumors

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Claudia Forni1, Mario Minuzzo1, Emanuela Virdis2, Elena Tamborini2, Matteo Simone3, Michele Tavecchio3, Eugenio Erba3, Federica Grosso2, Alessandro Gronchi2, Pierre Aman4, Paolo Casali2, Maurizio D'Incalci3, Silvana Pilotti2, Roberto Mantovani1

1Università degli Studi di Milano, Milan, Italy, 2Istituto Nazionale Tumori, Milan, Italy, 3Istituto Mario Negri, Milan, Italy, 4Göteborg University, Göteborg, Sweden


Members of the Proton-Assisted Amino Acid Transporter (PAT/SLC36) family are located in intracellular endosomal compartments that locally activate S6-kinase

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Deborah Goberdhan, Margret Ogmundsdottir, Shivanthy Visvalingam, Bruno Reynolds, Shubana Kazi, Richard Boyd, Clive Wilson

University of Oxford, Oxford, UK


The Role of c-FLIP in regulating pancreatic cancer cell death

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Kelly Redmond, Kirsty McLaughlin, Timothy Wilson, Emma Kerr, Patrick Johnston, Daniel Longley

Queen's University Belfast, Belfast, UK


Members of the Proton-Assisted Amino Acid Transporter (PAT/SLC36) family regulate growth in human cancer cell lines

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Shubana Kazi, Deborah Smith, David Meredith, Clive Wilson, C.A. Richard Boyd, Deborah C.I. Goberdhan

Oxford University, Oxford, UK


Specific inhibition of mitochondrial respiratory chain complex II by anti-cancer drugs leads to apoptosis induction

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Anthony LeMarie, Stefan Grimm

Imperial College London, Div. Investigative Sciences, London, UK


Direct c-Myc DNA binding mediates p15ink4b transcriptional repression

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Marie-Eve Beaulieu

Université de Sherbrooke, Quebec, Canada


Ataxia telangiectasia mutated(ATM) is required for the interferon-γ response

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Diane Watling1, Catarina R. Carmo1, Ian M. Kerr2, Ana P. Costa-Pereira1

1Imperial College London, London, UK, 2Cancer Research UK - London research Institute, London, UK


The role of RhoJ in endothelial cell biology and angiogenesis

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Sukhbir Kaur, Sabina Hiltbrunner, Roy Bicknell, Victoria Heath

University of Birmingham, Birmingham, UK


Determination of RhoJ signalling pathways in endothelial cells

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Katarzyna Bunko, Roy Bicknell, Victoria Heath

University of Birmingham, Medical School, Institute for Biomedical Research, Division of Immunity and Infection, Birmingham, West Midlands, UK


Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues

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Anita Grigoriadis1, Gavin Oliver2, Austin Tanner2, Howard Kendrick3, Matt Smalley3, Parmjit Jat4, A.Munro Neville1

1Ludwig Institute for Cancer Research, London, UK, 2Almac Diagnostics, Northern Ireland, UK, 3The Breakthrough Breast Cancer Research Centre, London, UK, 4Institute of Neurology, London, UK


Centrosome overduplication requires Cdk2 activity, nuclear export, microtubules, dynein and Hsp90

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Suzanna L Prosser, Andrew M Fry

University of Leicester, Leicester, UK


Modulation of human JAK/STAT pathway signalling by functionally conserved regulators and their potential role in myeloid leukemia

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Dhamayanthi Pugazhendhi, Patrick Muller, Martin Zeidler

University of Sheffield, Sheffield, South Yorkshire, UK


Significance of regulating Cdc6 during the initiation of DNA replication

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Lena R. Kundu, Yuji Kumata, Takashi Tsuyama, Masayuki Seki, Takemi Enomoto, Shusuke Tada

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan


PDF (Prostate Derived Factor) is a novel modulator of drug response in colorectal cancer cells

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Irina Proutski, Leanne Stevenson, Andrea McCulla, Wendy Allen, Daniel Longley, Patrick Johnston

CCRCB Quenns University, Belfast, Northern Ireland, UK


Characterization of the H2AX-mediated response to severe hypoxia

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Zuzana Bencokova, Isabel M. Pires, Ester M. Hammond

Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, UK


The role of LRP1 in oesophageal adenocarcinoma

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Keith Roberts1, Lewis Stevens1, Matthew Brookes1, Robert Spychal2, Tariq Iqbal1, Chris Tselepis1

1University of Birmingham, Birmingham, UK, 2Birmingham City Hospital, Birmingham, UK


Role for autophagy in the establishment of senescence

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Andrew Young, Masako Narita, Manuela Ferreira, Kristina Kirschner, Fiona Watt, Masashi Narita

Cancer Research UK, Cambridge, UK


Effect of processed and red meat on endogenous nitrosation and DNA damage

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Annemiek M.C.P. Joosen1, Gunter G.C. Kuhnle1, Timothy M. Barrow1, Amaia Azqueta Oscoz2, Sheila A. Bingham1

1MRC Dunn Human Nutrition Unit, Cambridge, UK, 2University of Oslo, Oslo, Norway


An RNA-protein complex containing Misu (NSun2) is required for mitotic spindle integrity

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Shobbir Hussain, Sandra Blanco-Benavente, Michaela Frye

Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge, UK


New alcoholic fixative and quality of nucleic acids

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Alessia Gazziero, Roberta Salmaso, Vincenza Guzzardo, Ambrogio Fassina

Department of Diagnostic Sciences and Special Therapy, University of Padova, Padova, Italy


Functional analysis of an essential F-box protein in fission yeast

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Nathalie Spielewoy1, James Thompson2, John R. Yates III2, Takashi Toda1

1Cancer Research UK, London, UK, 2The Scripps Research Institute, La Jolla, CA, USA


Multiple isoforms of HAX1 in murine and human tissues suggest a novel adaptor family of proteins

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Delphine M Lees, Ian R Hart, John F Marshall

Centre for Tumour Biology, Cancer Research-UK Clinical Centre, Bart's and The London, London, UK


RAN GTPase-controlled tumour suppression: RASSF1A tumour suppressor gene which is frequently inactivated in human cancers interacts with the RAN GTPase network

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Ashraf Dallol1, Luke Hesson1, Wendy Cooper1, Eamonn Maher1, Walter Kolch2, Farida Latif1

1University of Birmingham, Birmingham, UK, 2The Beatson Institute for Cancer Research, Glasgow, UK


Cross talk between the VEGF and Notch signalling pathways in endothelial cells

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Laura Harrington, Richard Sainson, Chern Ein Oon, Helen Sheldon, Ji-Liang Li, Adrian Harris

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK


Exposure to necrotic debris in tumours induces an aggressive, tumour-promoting phenotype in macrophages: role of toll-like receptor 4

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Russell Hughes1, Esha Kothari1, Craig Murdoch2, Claire Lewis1

1Tumour Targeting Group, University of Sheffield Medical School, Sheffield, South Yorkshire, UK, 2Dept Oral and Maxillofacial Surgery, School of Clinical Dentistry, Sheffield, South Yorkshire, UK


Targeting macrophage migration inhibitory factor in ovarian cancer prevents tumour angiogenesis and increases tumour cell apoptosis

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Mónica Escórcio-Correia, Robin Soper, Thorsten Hagemann

Queen Mary's School of Medicine and Dentistry, Centre for Cancer and Inflammation, London, UK


Investigating the interaction of cohesin with chromosomes

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Maria TA Ocampo-Hafalla, Frank Uhlmann

Cancer Research UK, London Research Institute, London, UK


TP53and P21 polymorphisms and risk of lung cancer in an Iranian population

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Farhad Mashayekhi, Zivar Salehi

University of Guilan, Rasht, Iran


Functional epigenomics identifies candidate tumour suppressor genes frequently methylated in renal cell carcinoma

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Mark Morris1, Dean Gentle1, Christopher Ricketts1, Noel Clarke2, Michael Brown2, Takeshi Kishida3, Masahiro Yao3, Farida Latif1, Eamonn Maher1

1Cancer Research UK Renal Molecular Oncology Group, University of Birmingham, Birmingham, UK, 2Paterson Institute for Cancer Research, University of Manchester, Manchester, UK, 3Yokohama City University School of Medicine, Yokohama, Japan


Lifestyle factors and primary glioma and meningioma tumours in the Million Women Study cohort

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Victoria Benson

Cancer Epidemiology Unit, University of Oxford, Oxford, UK