6719 abstracts found.



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HPV16 E6 stabilises and stimulates membrane localisation of the Rho guanidine exchange factor (GEF) 16 which specifically activates Cdc42

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Anthony W Oliver, Lynne Hampson, Xiaotong He, Katherine Borthwick, Jie Qi, Claire Walsh, Henry C Kitchener, Ian N Hampson

University of Manchester, Manchester, UK


Association of P-glycoprotein and Bcl-2 with multi-drug resistance in chronic lymphocytic leukaemia

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Shams Ismail1, Amira Khorshed2, Nahed Abdelwahab2, Thoraya Abdelhamid2

1National Research Center, Giza, Cairo, Egypt, 2National Cancer Institute, Cairo, Egypt


Have we been underestimating the relative risk of breast cancer after HRT use?

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Ailie Grzybek, Colin McCowan, Frank Sullivan, Alastair Thompson, John Dewar

University of Dundee, Dundee, UK


The IGF system in prostate cancer aetiology: a systematic review and meta-analysis

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Mari-Anne Rowlands1, David Gunnell1, Ross Harris1, Lars Vatten2, Jeff Holly1, Richard Martin1

1University of Bristol, Bristol, UK, 2Norwegian University of Science and Technology, Trondheim, Norway


Molecular basis for maize as a risk factor for oesophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism

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Ryan C. Pink1, Tracey A. Bailey1, Jehu E. Iputo2, Alastair M. Sammon3, Anthony C. Woodman1

1Cranfield Health, Cranfield University, Bedfordshire, UK, 2Dept of Physiology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa, 3Dept of Surgery, Gloucestershire Royal Hospital, Gloucester, UK


Folate, polymorphisms in folate-metabolising genes, and colorectal adenomas: results from a population-based case-only study

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Linda Sharp1, Julian Little2, Amanda Cardy3, Anne-Elie Carsin1, Susan Duthie4, Anne Molloy5, Nadine Holloway3, Ashley Mowat6, Bob Steele7, Roland Wolf8, John Wilson9, Neva Haites3

1National Cancer Registry, Cork, Ireland, 2University of Ottawa, Ottawa, Canada, 3University of Aberdeen, Aberdeen, UK, 4Rowett Research Institute, Aberdeen, UK, 5Trinity College, Dublin, Ireland, 6Aberdeen Royal Infirmary NHS Trust, Aberdeen, UK, 7Tayside University Hospitals, Dundee, UK, 8University of Dundee, Dundee, UK, 9Victoria Hospital, Kirkcaldy, UK


Pregnancy outcomes among adult survivors of childhood cancer

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Raoul Reulen, Maurice Zeegers, Emma Lancashire, Dave Winter, Mike Hawkins

University of Birmingham, Birmingham, UK


Familial non-VHL Clear Cell (Conventional) Renal Cell Carcinoma: clinical features, segregation analysis and mutation analysis of FCLN

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Emma R Woodward1, Christopher Ricketts1, Pip Killick1, Sophie Gad2, Mark Morris1, Fred Kavalier3, Shirley V Hodgson4, Sophie Giraud5, Brigitte Bressac2, Cyril Chapman6, Bernard Escudier2, Farida Latif1, Stéphane Richard2, Eamonn R Maher1

1Cancer Research UK Renal Molecular Oncology Group and Department of Medical and Molecular Genetics, University of Birmingham, Birmingham, UK, 2Institut de Cancérologie Gustave Roussy, Villejuif, France, 3Department of Clinical Genetics, Guy's Hospital, London, UK, 4Department of Medical Genetics, St George’s University of London, London, UK, 5Laboratoire de Génétique, Hôpital Edouard Herriot, Lyon, France, 6West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Birmingham, UK


What are the risk factors for CIN1 and CIN2/3 in women with a low-grade smear? Results from a case-control study nested in the UK Trial Of Management of Borderline and Other Low-grade Abnormal smears (TOMBOLA)

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Anne-Elie Carsin1, Seonaidh Cotton2, Linda Sharp1, Rashmi Seth3

1National Cancer Registry, Cork, Ireland, 2University of Aberdeen, Aberdeen, UK, 3Queens Medical Centre, Nottingham, UK


Molecular pathways involved in mediating effects of type 1 insulin-like growth factor receptor (IGF1R) signalling on sensitivity of melanoma cells to Temozolomide (TMZ)

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Roger Ramcharan, Nicholas Thomas, Johan Riedemann, Anthony Yeh, Mark Middleton, Valentine Macaulay

Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK


Histological Expression and function of complement molecules in ovarian cancer

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Abdulhafid Wafa1, Ian Scott3, Ian Spendlove2, Heidi Sowter1

1University of Derby, Derby, Derbyshire, UK, 2University of Nottingham, Nottingham, Nottinghamshire, UK, 3Derby City General Hospital, Derby, Derbyshire, UK


The development of HPV-related cervical cancer: The influence of NQO1 and p53 polymorphic variation

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Qasem Abdallah, Milene Volpato, Beryl Cronin, Sandie Martin, Roger Phillips

Institute of Cancer Therapeutics, University of Bradford, Bradford, UK


Disease associations of FGFR2, TNRC9 and MAP3K1 polymorphisms in breast cancer

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Amy Martin1, Lee Jordan2, Colin Purdie2, Alison Ashfield1, Lee Baker1, Philip R. Quinlan1, Fiona Carr1, Roger Tavendale1, Colin N.A. Palmer1, Alastair Thompson1, Jonathan Berg1

1University of Dundee, Dundee, UK, 2Ninewells Hospital and Medical School, Dundee, UK


Metabolite changes in the transition from pre-invasive to invasive cervical cancer using in vivo magnetic resonance spectroscopy

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Sonali De Silva, Geoffrey Payne, Veronica Morgan, John Shepherd, Thomas Ind, Desmond Barton, Nandita deSouza

Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK


Cancer patients with VTE have a distinct thrombosis risk factor profile compared with cancer-free patients with VTE

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Peter Rose1, Shankaranarayana Paneesha2, Aidan McManus3, Roopen Arya4, Timothy Farren5, Nicholas Scriven6, Tim Nokes7, Sue Bacon8, Anthea Nieland9, Harry Smith10, Denise O'Shaughnessy11

1Warwick Hospital, Warwick, UK, 2Heart of England NHS Foundation Trust, Birmingham, UK, 3MMRx Consulting, London, UK, 4King's College Hospital, London, UK, 5Barts and The London Hospitals, London, UK, 6The Calderdale Royal Hospital, Halifax, UK, 7Derriford Hospital, Plymouth, UK, 8Scarborough Hospital, Scarborough, UK, 9Northampton General Hospital NHS Trust, Northampton, UK, 10sanofi-aventis, Guildford, UK, 11Department of Health, London, UK


Physical activity, obesity and risk for esophageal adenocarcinoma

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Lloyd Balbuena, Alan Casson

University of Saskatchewan, Saskatoon SK, Canada


Identification of Jun dimerisation protein 2 (JDP2) as a novel cellular target of the Human T-cell Leukaemia Virus type 1 Tax oncoprotein

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Claire Walsh, Lynne Hampson, Anthony W. Oliver, Henry C. Kitchener, Ian N. Hampson

University of Manchester Gynaecological Oncology, School of Cancer Studies, Manchester, UK


Functional redundancy in viruses: an alternative E6AP independent mechanism by which high-risk HPV16 E6 facilitates the degradation of p53

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Wilawan Bunjobpol, Ian N. Hampson, Anthony W. Oliver, Xiaotong He, Jie Qi, Henry C. Kitchener, Lynne Hampson

University of Manchester, Gynaecological Oncology Labs, School of Cancer Studies, Manchester, UK


An investigation into the mode of action of the HIV protease inhibitor lopinavir against human papillomaviruses (HPV)

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Gavin Batman, Lynne Hampson, Anthony Oliver, Henry Kitchener, Ian Hampson

University of Manchester, Manchester, UK