6719 abstracts found.



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Defining the role of AP-1 in molecular adaptation to hypoxia in colorectal cancer

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Eric VANCAUWENBERGHE1,Hannah Bolland2,Christopher Carroll2,Leonardo Da Motta2,Anna Grabowska3,Francesca Buffa4,Adrian Harris5,Alan McIntyre2
1Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,2Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,3Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, UK,4Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford, Oxford, UK,5Molecular Oncology Laboratories, Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Carbonic Anhydrase 9 Confers Resistance to Ferroptosis/Apoptosis in Malignant Mesothelioma Under Hypoxia

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Zan Li1,Li Jiang1,Shinya Toyokuni1
1Nagoya University Graduate School of Medicine

Factors associated with Emergency Admissions for Cancer Patients in Last year of life in a UK region

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Victoria Cairnduff1,Laura Dwyer1,Colin Fox1,Gregory Fallica2,Kelly Shiell-Davis3,Anna Gavin1
1Northern Ireland Cancer Registry, Belfast, UK,2Macmillan Cancer Support,3Macmillan Cancer Support, London, UK

Costs to patients and health service associated with immune checkpoint inhibitor-mediated colitis – a single site experience.

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Binu Chandrasekharapillai Janardanan Nair1,Dana Shor1,Tim Raine1,Pippa Corrie1,Sarah J Welsh1
1Cambridge University Hospitals NHS Foundation Trust

The impact of type 2 diabetes on survival in patients with cancer independent of its effect on survival in individuals without cancer: a matched cohort analysis

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Andrew Renehan1,Nasra Alam1,Alison Weight1,Martin Rutter1,Matthew Sperrin1,Darren Ashcroft1,Andrew Renehan1
1University of Manchester, Manchester, UK

Cancer Work Support Service (CWSS): An innovative Vocational Rehabilitation service supporting cancer survivors return to work

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Julie Denning1
1Working To Wellbeing

Timeliness of treatment in rectal cancer and survival: A population-based study using a mediation approach

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Rosie Dew1,Jonathan Pratschke2,Lousie Hayes1,Linda Sharp1
1Newcastle University,2University of Naples "Federico II"

Verification of a Cartridge-based Microsatellite Instability (MSI) Platform and Cross-platform Assessment of Cases with Rare Germline Polymorphic Markers

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Gareth Gerrard1,Diana Pelka2,Nicole Gurunlian1,Georgina Briggs1,Jack Grant1,Kevin Balibi1,Phil Bennett1
1Sarah Cannon Molecular Diagnostics,2HCA Healthcare UK

Apoptotic pancreatic cancer cells induce apoptosis in mesenchymal stromal cells

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Ester Pfeifer1,Debashis Sarker1,Joy Burchell1,Francesco Dazzi1
1King's College London

Improving Outcomes For Immunotherapy-Induced Endocrinopathies in Metastatic Melanoma

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Christina Peters1,Carolyn Tang1,Joyce Ntata1,Yvette Moore1,Ankit Rao1,Poulam Patel1
1Nottingham University Hospitals NHS Trust

Strategic system change to increase patient access to research

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Maria Maguire1,Sheena Khanduri2
1The Clatterbridge Cancer Centre NHS Foundation Trust,2The Clatterbridge Cancer Centre NHS Foundation Trust

Changing patterns in internet use in women with breast cancer. A 15 year analysis in a UK cancer centre

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Richard Simcock1,Leroy Okonta1
1Sussex Cancer Centre

Using linked English cancer registration data to assess variation in diagnostic pathway length

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Clare Pearson1,Jess Fraser1,Sara Hiom1,Jon Shelton1,Jodie Moffat1
1Cancer Research UK

The direct and indirect effects of affluence on survival in colon cancer: A population-based study

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Rosie Dew1,Jonathan Pratschke2,Louise Hayes1,Linda Sharp1
1Newcastle University,2University of Naples "Federico II"

The effects of indigenous South African plant extracts (Cotyledon orbiculata and Tulbaghia. Violacea) on triple negative breast cancer cells

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Mohammed Alaouna1,Rodney Hull2,Clem Penny3,Zodwa Dlamini4
1witwatersrand university,2Pretoria University,3University of the Witwatersrand,4University of Pretoria

Molecular and functional studies on a sub-population of T cells resistant to Galectin-9

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Thi Bao Tram Tran1,Aurore Gelin1,Philippe Rameau1,Cyril Catelain1,Valentin Baloche1,Pierre Busson1
1Gustave Roussy Institute, Villejuif, France

International Trends in Oesophageal Cancer Survival by Histological Subtype: A population-based study from seven high-income countries 1995-2014

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Eileen Morgan1,Isabelle Soerjomataram1,Aude Bardot1,Jacques Ferlay1,Freddie Bray1,Melina Arnold1
1International Agency for Research on Cancer

18F-FDG-PET in Guided Dose-Painting with Intensity Modulated Radiotherapy in Oropharyngeal Tumours – Final Toxicity and Disease Outcomes of FiGaRO Phase I Multicentre Feasibility Study

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Delali Adjogatse1,Andriana Michaelidou2,Yae-Eun Suh1,Lucy Pike2,Christopher Thomas3,Owain Woodley4,Beatriz Sanchez Nieto5,Tom Rackley6,Nachi Palaniappan6,Vetrisudar Jayaprakasam7,Mererid Evans6,Mary Lei1,Sally Barrington2,Teresa Guerrero Urbano1
1Dept of Oncology, Guy's and St Thomas NHS Foundation Trust, London, UK,2King's College London and Guy's and St Thomas PET Centre, London, UK, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK,3Department of Medical Physics, Guy's and St Thomas NHS Foundation Trust, London, UK, King's College London and Guy's and St Thomas' PET Centre, London, UK, School of Biomedical Engineering and Imaging Sciences, King's College London, King's Health Partners, London, UK,4Medical Physics Dept, Velindre University NHS Trust, Cardiff, UK,5Faculty of Physics, Pontificia Universidad Catolica de Chile, Santiago, Chile,6Dept of Oncology, Velindre University NHS Trust, Cardiff, UK,7Wales Research and Diagnostic PET Imaging Centre, Cardiff, UK

Investigating COX isoform dependency in intestinal tumourigenesis

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Noha-Ehssan Mohamed1,Rachel Ridgway1,Owen Sansom1
1Cancer Research UK Beatson Institute, Glasgow, UK

Barriers to accessing cancer services in England and Wales by adults with physical disabilities

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Dikaios Sakellariou1,Sally Anstey2,Molly Courtenay2,Daniel Kelly3,Sarah Polack4,Eleri Girt5,Wendy Wilkinson5
1Cardiff University, Cardiff, UK ,2Cardiff University, Cardiff, UK,3Cardiff University,4London School of Hygiene and Tropical Medicine,5Wales Cancer Network, Cardiff, UK

High-content Profiling in Oesophageal Adenocarcinoma Identified Selectively Active Compounds for Repurposing and Novel Drug Discovery

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Rebecca Hughes1,Richard Elliott2,Ashraff Makda2,Robert O'Neill3,Ted Hupp2,Neil Carragher2
1University of Edinburgh,2UNIVERSITY OF EDINBURGH,3Cambridge Oesophagogastric Unit

Safety and efficacy of 12 mg/d lenvatinib (LEN) in patients with unresectable hepatocellular carcinoma (uHCC) and bodyweight >80 kg in REFLECT

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Arndt Vogel1,Masatoshi Kudo2,Ann-Lii Cheng3,Max W. Sung4,Richard S. Finn5,Albert Y. Lin6,Ghassan K. Abou-Alfa7,Angel Alsina8,Valeriy Breder9,Niall Tebbutt10,Pia Osterlund11,C. J. Yen12,Min Ren13,Soamnauth Misir13,Corina E. Dutcus13,Daniel Palmer14,Philippe Merle15,Matthias Pinter16,TR Jeffry Evans17
1Hannover Medical School,2Kindai University School of Medicine,3National Taiwan University Hospital,4Tisch Cancer Institute at Mount Sinai,5Geffen School of Medicine, UCLA Medical Center,6VA Palo Alto Health Care System,7Memorial Sloan Kettering Cancer Center,8Tampa General Hospital,9N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation,10Olivia Newton-John Cancer Centre,11Tampere University and Central Hospital,12National Cheng Kung University Hospital,13Eisai Inc.,14University of Liverpool, Liverpool,15CHU de Lyon -Hospital La Croix-Rousse,16Medical University of Vienna,17University of Glasgow

Making Big Data available: Informatics Infrastructure supporting the MRC/CRUK funded Stratification in COloRecTal Cancer (S-CORT) programme

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Andrew Blake1,Enric Domingo1,Michael Youdell1,Susan Richman2,Peter Stewart3,Celina Whalley4,Clare Hardy5,Katerina Chatazipli5,on behalf of S-CORT Consortium6,Tim Maughan1
1University of Oxford,2University of Leeds,3Queens University Belfast,4University of Birmingham,5Wellcome Trust Sanger Institute,6S-CORT Consortium

Mutation analysis of Beta2-Microglobulin identifies a subset of deficient mismatch repair (dMMR) colorectal cancers which are protected from disease recurrence.

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Susan Richman1,Paul Barrow2,Andrew Wallace3,Kelly Handley4,Gordon Hutchins5,David Kerr6,Laura Magill4,Gareth Evans3,Richard Gray6,Phil Quirke5,James Hill2
1Leeds Teaching Hospitals NHS Trust,2Manchester Royal Infirmary,3Central Manchester University Hospitals NHS Trust,4University of Birmingham,5University of Leeds,6University of Oxford

Can people living with and beyond colorectal cancer make lifestyle changes with the support of health technology?

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Victoria Aubrey1,Clare Shaw2
1The Royal Marsden NHS Foundation Trust,2Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London and Sutton

Phenotyping neutrophil subpopulations in advanced lung cancer

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Robert Grecian1,Patricia Dos Santos Coelho1,Emily Watts1,Kev Dhaliwal1,Adam Byron1,Margaret Frame1,Moira Whyte1,Sarah Walmsley1
1Edinburgh University

Inhibiting Ehmt2 and Ezh2 histone methyltransferases alters the immune microenvironment in a Trp53-/- murine ovarian cancer model

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Pavlina Spiliopoulou1,Sarah Spear2,Patricia Roxburgh3,Susanne Dowson4,Susan Mason4,Karen Blyth4,Matthew Fuchter2,Bob Brown2,Iain A McNeish2
1Beatson West of Scotland Cancer Centre, Glasgow, UK,2Imperial College London, London, UK,3Beatson West of Scotland Cancer Centre,4University of Glasgow, Glasgow, UK

The p53/p21 axis suppresses 5FU-induced, ATM/ATR-STAT3-mediated activation of PD-L1

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Tamas Sessler1,Fiammetta Falcone2,Peter Gallagher2,Daniel Longley2,Simon McDade2
1Centre for Cancer Research & Cell Biology Queen's University Belfast, Belfast, UK, Forensic Geoscience Group Queen's University Belfast, Belfast, UK,2Queen's University Belfast, Belfast, UK

Cancer Antigen Presentation in Colorectal Cancer Local Metastases

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Thomas Starkey1,Thomas Starkey1,Tessa Sanberg2,Roland Arnold1,Ian Tomlinson1,Lennard Lee1
1University of Birmingham,2Universiteit Leiden

A screen for epigenetic reprogramming reveals LSD1 inhibitor as a potential intervention to promote differentiation in pancreatic cancer

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Frances Willenbrock1,James Wantling1,Eric O'Neill1
1University of Oxford, Oxford, UK

Understanding challenges to palliative care engagement within the early phase trials setting

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Mary Lomas1,Sandie Wellman1
1Oxford University Department of Oncology

Variation in pre-diagnostic investigation use and test-to-diagnosis intervals by comorbidity status and socio-demographic characteristics in patients subsequently diagnosed with colorectal cancer

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Sara Benitez Majano1,Georgios Lyratzopoulos2,Bernard Rachet1,Cristina Renzi2
1LSHTM,2UCL

Time on treatment and treatment patterns in patients with metastatic colorectal carcinoma: a retrospective chart review

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Anna Ryan1,Daniel Sugrue2,Michael Hurst2,Pratik Thakkar3,Sidonie Hartridge-Lambert3,Hamzeh Kayhanian1,Jason Gordon2,Manuel Rodriguez-Justo1,Kai-Keen Shiu1,Dionysios Ntais3
1University College London Hospital,2Health Economics and Outcomes Research Ltd.,3Bristol-Myers Squibb

Predicting platinum chemotherapy sensitivity in advanced oesophageal cancer using a DNA Damage Immune Response (DDIR) assay

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Mark Baxter1,Shaun Walsh2,Russell Petty1
1University of Dundee,2NHS Tayside

Breast adipocyte diameter, adult weight gain, anthropometry and lifestyle habits in women with breast cancer

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Sofia Laforest1,Francine Durocher1,André Tchernof1,Caroline Diorio1
1Université Laval

RELEVANT study: Patient and physician perspectives on clinically-meaningful outcomes in advanced pancreatic ductal adenocarcinoma (PDAC).

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Rille Pihlak1,Melissa Frizziero2,Soo Yit Gustin Mak2,Christina Nuttall2,Angela Lamarca2,Richard A Hubner2,Janelle Yorke1,Juan W Valle1,Mairéad G McNamara1
1The Christie NHS Foundation Trust/ The University of Manchester,2The Christie NHS Foundation Trust

Investigating the role of NF-κB/RelA in hypoxia induced stemness and EMT characteristics using NF-κB overexpression and CRISPR/Cas9- knockout models of glioblastoma cells.

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Samna Sagadevan1,Ben Smith1,Vinodh Kannappan1,Sathishkumar Kurusamy1,Karim Azar1,Weiguang Wang1
1University of Wolverhampton

Circulating Ensembles of Tumor Associated Cells are Ubiquitous in Breast, Ovarian and Cervical Cancers and Atypical in Asymptomatic Individuals.

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Dadasaheb Akolkar1,Darshana Patil1,Raymond Page2,Vineet Datta1,Revati Patil1,Pradip Fulmali1,Pooja Fulmali1,Navin Srivastava1,Pradip Devhare1,Sachin Apurwa1,Shoeb Patel1,Sanket Patil1,Ajay Srinivasan1,Rajan Datar1
1Datar Cancer Genetics Limited,2Worcester Polytechnic Institute

Nutrition support in childhood cancer: a systematic review and meta-analysis update

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Alix Dunlop-Jones1,Scarlett Brandley2,Robert Phillips3

1Leeds Teaching Hospitals NHS Trust,2Leeds University,3York University


Optimisation of a Selection Strategy for Drug Resistance Osteosarcoma Cell Lines

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Kaan Low1,Frank Hills1,Helen Roberts1,Britta Stordal1
1Middlesex University

Smoking cessation for cancer prevention: Can incentives play a role? Evidence from a Cochrane review

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Caitlin Notley1,Sarah Gentry2,Jonathan Livingstone-Banks3,Linda Bauld4,Rafael Perera3,Jamie Hartman-Boyce3
1Norwich Medical School, Norwich, UK,2University of East Anglia, Norwich, UK,3Cochrane, University of Oxford, Oxford, UK,4University of Edinburgh, Edinburgh, UK

Bioelectical impedance changes during chemotherapy for early breast cancer: The Cando-2 study

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Stephen Wootton1
1University of Southampton, Southampton, UK

Age differences in patient concerns after Breast Cancer. An analysis of UK Electronic Holistic Needs Assessment data

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Richard Simcock1,Oliver Wilson2,David Egan3,Taha Itani2
1Sussex Cancer Centre,2Macmillan Cancer Support,3Macmillan Cancer Suport

Improving the effectiveness of breast cancer multidisciplinary team (MDT) meetings: Implementation of a pre-MDT triage meeting

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Hannah Winter1,Dorra Al-Saadoon1,Jennifer Hu1,Virginia Wolstenholme1
1St Bartholomew's Hospital

Coffee consumption by type and risk of digestive cancer: A large prospective cohort study.

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Kim Tu Tran1,Helen Coleman1,Úna McMenamin1,Chris Cardwell1
1Queen's University Belfast

Avoidable harm: making decisions about chemotherapy with advanced lung cancer patients

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Annamarie Nelson1,Longo Mirella1,Stephanie Sivell1,Anthony Byrne1,Jason Lester2,Despina Anagnostou1,Catherine Sampson1
1Marie Curie Palliative Care Research Centre, Cardiff University, School of Medicine, Cardiff,2Velindre NHS Trust, Cardiff

Outcomes in patients age 70 and above treated with radical radiotherapy for Head & Neck Cancer

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Saurabh Borgaonkar1,Lisa Hay1,Claire Paterson1,Derek Grose1,Carolynn Lamb1,Stephano Schipani1,Christina Wilson1,Allan James1,Maureen Thomson1
1Beatson

CEBOC: Evaluation of the safety of Cediranib in the prevention of Bowel perforation in platinum-resistant Ovarian Cancer

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Ann White1,Andrew Clamp2,Robert Morgan2,Dilly Goonetilleke3,Angela Casbard4,Tracie-Ann Madden4,Jennifer Swettenham4,Alkesh Patel2,Charlotte Wilhelm-Benartzi4,Catherine Rogers2,Gordon Jayson2
1,2The Christie NHS Foundation Trust,3The University of Manchester,4Cardiff University

What accessible interventions are available to support cancer survivors to improve their quality of life?

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Nikki Hayward1,Sally Markwell2
1Oxford University Hospitals NHS Trust, Oxford, UK,2Oxford Brookes university

Collaboratively assessing the impact of patient and public involvement in research

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Sarah Stapleton1,Martin Lee2
1Royal Marsden Hospital and Institute of Cancer Research,2Royal Marsden and Institute of Cancer Research