719 abstracts found.



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The predictive value of CA125 for ovarian cancer in General Practice: a population-based cohort study of over 50,000 women

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Garth Funston1,Willie Hamilton2,Gary Abel2,Emma Crosbie3,Brian Rous4,Fiona Walter1

1Department of Public Health and Primary Care, University of Cambridge,2University of Exeter,3Gynaecological Oncology Research Group, Division of Cancer Sciences, University of Manchester,4National Cancer Registration and Analysis Service, Public Health England


Interim results from the IMPACT study: evidence for PSA screening in BRCA2 mutation carriers

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Rosalind Eeles1,Elizabeth Page2,Elizabeth Bancroft3,Mark Brook1,Melissa Assel4,Judith Offman5,Zsofia Kote-Jarai1,Andrew Vickers4,Hans Lilja4,The IMPACT study Steering Committee and IMPACT study collaborators6

1The Institute of Cancer Research, London, UK,2The Institute of Cancer Research,3Royal Marsden NHS Foundation Trust, London, UK,4Memorial Sloan Kettering Cancer Center, New York, US,5King’s College London, London, UK,6the Institute of Cancer Research


Oncogenic Ras/ERK signalling alters cell shape and mechanics to facilitate cell division under confinement

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Helen Matthews1,Sushila Ganguli1,Katarzyna Plak1,Anna Taubenberger2,Jochen Guck2,Buzz Baum1
1University College London,2TU Dresden

Combination of caloric restriction and lysine-specific demethylase 1 (LSD1) inhibition in the treatment of acute myeloid leukemia

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Rani Pallavi1,Luca Mazzarella1,Tiphanie Durfort1,Elena Gatti1,Bruno Achutti Duso1,Massimo Stendardo1,Luciano Giaco1,Ciro Mercurio2,Mario Varasi2,Marco Giorgio1,Saverio Minucci1,Pier Giuseppe Pelicci1
1European Institute of Oncology,2FIRC Institute of Molecular Biology

Genome-wide CRISPR screen in 3D intestinal organoids to define novel mechanisms critical for colorectal tumorigenesis

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Patrizia Cammareri1,Eline Janssen2,Caroline Billard2,Michela Raponi2,Victoria Gudino2,Stuart Aitken2,Alfonso Bolado Carrancio2,Alex Von Kriegsheim2,Abdolrahman Nateri3,Kevin Myant2
1ECRC,2Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine,3Cancer Biology Unit, Division of Cancer & Stem Cells. School of Medicine, University of Nottingham

A high-throughput sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

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Eleanor Watt1
1UCL

Nr4a1-loss causes an acceleration of Myc-driven lymphomagenesis and an induction of gene of the B7-CD28

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Alexander Deutsch1,Katrin Pansy1,Christine Beham-Schmid1,Andreas Prokesch1,Julia Feichtinger1
1Medical University of Graz, Graz, Austria

Neo-epitopes/antigens discovery for cancer immunotherapy based treatment with precision oncology using advanced Artificial Intelligence

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Jyothi Deva datta reddy1,Deva Reddy2,Dr.ram Reddy2,Samyukta Jyothi2
1Cancer moonshot @ www.cancermoonshot.in,2Cancermoonshot

Accelerating early identification of cancer in primary care using an artificial intelligent driven solution.

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Bhavagaya Bakshi1
1C the Signs

Population-based genetic testing of 16,000 healthy Australian women for germline mutations in hereditary breast and ovarian cancer predisposition genes

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Ian Campbell1,Lisa Devereux1,Simone Rowley1,Na Li1,Alison Trainer1,Paul James1
1Peter MacCallum Cancer Centre

Access to and experiences of medication, devices, and support for sexual dysfunction in men with prostate cancer: finding from a UK-wide study

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Eila Watson1,Sarah Wilding2,Lauren Matheson1,Eilis McCaughan3,Jo Brett1,Amy Downing2,Penny Wright2,Adam Glaser2,Anna Gavin4,Richard Wagland5
1Oxford Brookes University,2University of Leeds,3Ulster University,4Queens University Belfast,5University of Southampton

Should major surgery be offered to elderly patients with early-stage lung cancer? An emulated trial using observational data in England

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Camille Maringe1,Clémence Leyrat1,Sara Benitez Majano1,Aimilia Exarchakou1,Matthew Smith1,Bernard Rachet1,Aurélien Belot1
1London School of Hygienen and Tropical Medicine, London, UK

Making Outcome-Based Payment for Cancer Medicines a Reality in the NHS

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Amanda Cole1,Patricia Cubi-Molla1,Jack Pollard2,Duncan Sim3,Richard Sullivan4,Jon Sussex2,Paula Lorgelly4
1Office of Health Economics, London, UK,2RAND Europe, Cambridge, UK,3Cancer Research UK, London, UK,4King's College London, London, UK

Can a simple institutionalised approach to cancer pain assessment and management in cancer centres improve pain outcomes and save money?

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Marie Fallon1,Peter Hall1,Katharina Dienberger1
1University of Edinburgh

Effective clinical cancer treatment, care and management for people with comorbid cancer and dementia: understanding population demographics and intervention priorities and outcomes (CanDem-Int)

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Michelle Collinson1,Ellen Mason1,Laura Ashley2,Amanda Farrin1,Alys Griffiths3,June Hennell4,Rachael Kelley3,Claire Surr3
1Clinical Trials Research Unit, University of Leeds, Leeds, UK,2School of Social Sciences, Leeds Beckett University, Leeds, UK,3Centre for Dementia Research, Leeds Beckett University, Leeds, UK,4Centre for Dementia Research Expert by Experience group, Leeds Beckett University, Leeds, UK

Uncovering the long tail of oesophageal cancer driver genes for patient stratification

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Lorena Benedetti1,Thanos Mourikis1,Elisabeth Foxall1,Damjan Temelkovski1,Joel Nulsen1,Juliane Perner2,Matteo Cereda3,Christopher Yau4,Rebecca Fitzgerald2,Michael Howell1,Paola Scaffidi1,Francesca Ciccarelli1
1The Francis Crick Institute, London, UK,2University of Cambridge, Cambridge, UK,3Italian Institute for Genomic Medicine, Torino, Italy,4University of Birmingham, Birmingham, UK

Efficacy and safety of the combination of nivolumab (NIVO) plus ipilimumab (IPI) in patients with symptomatic melanoma brain metastases (MBM; CheckMate 204)

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Hussein Tawbi1,Peter Forsyth2,F. Stephen Hodi3,Christopher Lao4,Stergios Moschos5,Omid Hamid6,Michael B. Atkins7,Karl Lewis8,Reena P. Thomas9,John A. Glaspy10,Sekwon Jang11,Alain Algazi12,Nikhil I. Khushalani2,Michael A. Postow13,Anna C. Pavlick14,Marc Ernstoff15,David A. Reardon3,Agnes Balogh16,Jasmine Rizzo16,Kim Margolin17
1University of Texas MD Anderson Cancer Center, Houston, US,2Moffitt Cancer Center and Research Institute, Tampa, US,3Dana-Farber Cancer Institute, Boston, US,4University of Michigan, Ann Arbor, US,5University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, US,6The Angeles Clinic and Research Institute, Los Angeles, US,7Georgetown Lombardi Comprehensive Cancer Center, Washington, US,8University of Colorado Comprehensive Cancer Center, Aurora, US,9Stanford University Hospital, Stanford, US,10Jonsson Comprehensive Cancer Center University of California, Los Angeles, US,11Inova Schar Cancer Institute, Falls Church, US, Virginia Commonwealth University, Richmond, US,12University of California–San Francisco, San Francisco, US,13Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, US,14New York University Langone Medical Center, New York, US,15Roswell Park Cancer Institute, Buffalo, US,16Bristol-Myers Squibb, New York, US,17City of Hope, Duarte, US

TRACERx – TRAcking non-small cell lung Cancer Evolution through therapy (Rx)

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Mariam Jamal-Hanjani1

1UCL Cancer Institute


Epigenetic sensitization of non-small cell lung cancer to 5-Fluorouracil

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Israa Al-Humairi1
1University of LIverpool

Investigation into the Role of Protein Phosphatase 4 Regulatory Subunits in Leukaemia

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Mirna Mourtada-Maarabouni1,Mathilda Abou Faycal Abou Faycal2,Assem Elkak2,Anwar Hasan1
1Keele University,2Lebanese University

PARKIN protein expression and its impact on the survival of patients with advanced colorectal cancer

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Claudia Caroline Veloso da Silva1,Rosimeri Kuhl Svoboda Baldin2,Nayanne Louise Costacurta1,Amanda Pereira Agostinho1,Márcia Olandosk1,Lúcia de Noronha1,Vanessa Santos Sotomaior1
1Pontifícia Universidade Católica do Paraná,2Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR)

Tracking Renal Cancer Evolution reveals deterministic routes to tumour progression

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Kevin Litchfield1
1The Francis Crick Institute

Reactive Oxygen Species (ROS) modulation as a strategy to improve chemo-sensitivity in homologous recombination stratified epithelial ovarian cancer

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Chandan Mondal1,Chandan Mondal2,Eswara Murali Satyavarapu3,Chitra Mandal3
1Tata Medical Center and Tata Translational Cancer Reseach Center, Kolkata,2Tata Medical Center,3CSIR-Indian Institte of Chemical Biology

Retinoid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma, breast cancer and renal carcinomas: mRNA expression pattern

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Julius Brtko1,Lucia Bialesova1,Vladimir Lenko2,Stefan Galbavy3,Jan Podoba3,Dana Macejova1
1Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava,2University Hospital, Bratislava,3Saint Elizabeth Institute of Oncology, Bratislava

Investigating the effect of combination therapy on cetuximab inhibition of epidermal growth factor receptor signalling combined with dynamin inhibition in head and neck cancer squamous cell carcinoma

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Hui Yi Chew1,Adam McCluskey2,Phillip Robinson3,Benedict Panizza4,James Wells1,Riccardo Dolcetti1,Fiona Simpson1
1The University of Queensland Diamantina Institute, Brisbane, Queensland,2Centre for Chemical Biology, Chemistry, University of Newcastle, Callaghan, NSW,3Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, NSW,4Department of ENT Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland

Effect of cAMP on the migration, proliferation, invasion and trans-endothelial migration of Neuroblastoma cells

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Rabiu Fage Inuwa1,John Quayle2,Diana Moss2
1Institute of Translational Medicine, University of Liverpool,2Department of cellular and molecular physiology, University of Liverpool

Novel method for studying the in-vitro effects of anti-cancer agents: the assay of thymidine kinase 1 (TK1) in cell culture utilising AroCell TK 210 ELISA

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Kiran Kumar Jagarlamudi1,Liya Wang2,Staffan Eriksson3
1AroCell AB www.arocell.com,2Swedish Agricultural University,3Swedish Agricultural University, AroCell AB

Apoptosis-inducing therapeuticals promote ectodomain shedding of hypoxia-regulated carbonic anhydrase IX

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Michal Pastorek1,Ivana Vidlickova2,Miriam Zatovicova2,Silvia Pastorekova2
1Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic,2Department of Molecular Medicine, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovak Republic

Overcoming resistance to arginine deprivation therapy in Malignant Pleural Mesothelioma

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Marta Freitas1,Peter Szlosarek1,Sarah A. Martin1
1Barts Cancer Institute

Non-Random Mis-Segregation of Human Chromosomes.

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Sarah McClelland1,Joseph Worrall2,Naoka Tamura1,Alice Mazzagatti1,Nadeem Shaikh1,Tineke van Lingen1,Bjorn Bakker3,Elina Vladimirou4,Floris Foijer3
1Barts Cancer Institute,2Barts Cancer Institute, Queen Mary University of London,3ERIBA,4UCL Cancer Institute

Can CRISPR/Cas9 screens find new synthetic lethal targets for cancer ?

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Jon Moore1
1Horizon Discovery

[10]-gingerol increases doxorubicin antitumoural and antimetastatic activity while decreases its undesired side effects in a triple negative breast cancer mouse model

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Ana Carolina Martin1,Rebeka Tomasin1,Marina Naves1,Angelica Graminha1,Liany Luna-Dulcey1,Ramon Teles1,Marcia Cominetti1
1Federal University of São Carlos

Validation of putative metastasis suppressor genes identified by an in vivo functional shRNA screen in a triple-negative breast cancer model

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Rebeka Tomasin1,Richard Redvers2,Marcia Cominetti1,Kaylene Simpson3,Robin Anderson2
1Federal University of São Carlos,2Olivia Newton John Cancer Research Institute,3Peter MacCallum Cancer Centre - Victorian Comprehensive Cancer Research Institute

Targeting FOXM1 as a therapeutic strategy in cancer

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Rebecca Downing1,Marta O. Freitas1,Wai Yiu Tse1,Sarah A. Martin1
1Barts Cancer Institute

The role of Senataxin in radiobiological hypoxia

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Shaliny Ramachandran1,Pedro Victori1,Iosifina Foskolou1,Katarzyna Leszczynska1,Kienan Savage2,Ester Hammond1
1University of Oxford,2Queen’s University Belfast

A Predictive model of ‘on target’ drug resistance

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Daniel O'Neill1,Mike Firth1,Maryam Clausen1,Jonathan Wrigley1,Emanuela Cuomo1
1AstraZeneca

Development of first-in-class USP7 inhibitors using structure-based design

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Andrew Turnbull1,Stephanos Ioannidis2,Wojciech Krajewski3,Adan Pinto-Fernandez4,Claire Heride5,Agnes Martin3,Louise Tonkin3,Elizabeth Townsend2,Shane Buker2,David Lancia Jr.2,Christopher Dinsmore2,Tim Hammonds3,Sunkyu Kim2,Sylvie Urbe5,Michael Clague5,Benedikt Kessler4,David Komander6
1cancer research technology ltd,2FORMA Therapeutics,3CRUK Therapeutic Discovery Laboratories,4Oxford University,5Liverpool University,6Medical Research Council Laboratory of Molecular Biology

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

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Sandra Van Schaeybroeck1,Nicholas Forsythe1,Alaa Refaat1,Arman Javadi1,Hajrah Khawaja1,Jessica-Ann Weir1,Heba Emam1,Wendy Allen1,Frank Burkamp2,Vlad Popovici3,Puthen Jithesh4,Claudio Isella5,Melissa Labonte1,Ian Mills1,Patrick Johnston1
1Queen's University Belfast,2Almac Discovery Laboratories,3Masarykova Univerzita,4Sidra Medical and Research Centre,5University of Torino School of Medicine

The RalB small GTPase-SEC5 effector complex regulates survival of RAS mutant colorectal cancer by regulating trafficking of DR5

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Hajrah Awais Khawaja1,Emma Evergren1,Jamie Roberts1,Daniel Longley1,Paul O'Reilly1,Darragh McArt1,Patrick Johntson1,Timothy Harrison1,Sandra Van Schaeybroeck1
1Queen's University Belfast

Human aldehyde dehydrogenase 7A1 (ALDH7A1) expression affects cancer cell proliferation, migration and cell protection against oxidative stress

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Lina Elsalem1,Anaxagoras Fotopoulos2,Simon Allison3,Jan Moreb4,Zoe Cournia2,Klaus Pors5
1Jordan University of Science and Technology,2Biomedical Research Foundation,3University of Huddersfield,4Hematological Malignancies,5University of Bradford

Genetically encoded photocrosslinking amino acids for in-cell kinase substrate identification

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Khalil Davis1,Joanna Kelly1,Silvia Martini1,Aaron Borg1,David Mann2,Alan Armstrong2,Peter Parker1
1The Francis Crick Institute,2Imperial College London

“I knew things were changing and I couldn’t figure it out”: the BRAin tumour Early Detection (BRAcED) study – implications for public awareness and GP education

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Fiona Walter1,Clarissa Penfold1,Alexis Joannides1,William Sage1,Andrew Brodbelt2,Michael Jenkinson3,Stephen Price4,Colin Watts5,Joyce Bell6,Margaret Johnson6,Willie Hamilton7
1University of Cambridge,2Consultant neurosurgeon, The Walton Centre, Liverpool,3Clinical Senior Lecturer in Neurosurgery, University of Liverpool,4Cambridge Neuroscience, University of Cambridge,5Consultant Neurosurgeon, University of Cambridge,6PPI c/o University of Cambridge,7University of Exeter

Is This As Good As It Gets? The English Cancer Patient Experience Survey 2016 – Research Discussions Reported by Patients Since 2012

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Richard Stephens1,Carolyn Morris1,Mat Baker1
1NCRI

Better Conversations – Better Care : Evaluation of Training within the Serious Illness Care Programme UK

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Anita Roberts1,Alison Coakley2,Helen Bonwick3,Andrew Khodabukus4,Susan Block5,Justin Sanders5,Francine Maloney5,Jo Paladino5,Tamsin McGlinchey1,Maria Maguire2,Stephen Mason1,Peter Kirkbride2,John Ellershaw1
1University of Liverpool,2Clatterbridge Cancer Centre,3Marie Curie Cancer Care,44Royal Liverpool and Broadgreen University Hospitals NHS Trust,5Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health, Ariadne Labs, Boston, MA

Describing the Three Cancer Groups

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Rachel White1,Jane Maher1
1Macmillan Cancer Support

Open to change – a success story: the north manchester macmillan palliative care support service

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Niamh Lyons1,Kelly Singh2
1Macmillan Cancer Support,2ICF Consulting

LIVERPOOL, NOVEMBER 2017 Exposure to chemotherapy induces epigenetic damage in normal cells in childhood cancer survivors

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Jill McKay1,Linda Sharp1,John Casement1,Gordon Strathdee1
1Newcastle University

Dissecting the Ubiquitination function of the metastasis-promoting protein Podocalyxin

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Mohammed A. Mansour1
1Cancer Research UK Beatson Institute

A Chemotherapy Digital app can improve monitoring of toxicity and support patients on treatment

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Kerrie Fleming1,Sheena Khanduri1
1Royal Shrewsbury Hospital

Carer perspectives of the value of specialist residential weekends for young people with cancer

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Ana Martins1,Rachel M Taylor1,Sue Morgan2,Jennie Bradley3,lorna A Fern1
1University College London Hospitals NHS Trust,2Leeds Teaching Hospitals NHS Foundation Trust,3Quality Health