¹Genentech, South San Francisco, USA

¹Ontario Institute for Cancer Research, Toronto, Canada

¹Harvard Medical School & Massachusetts General Hospital Cancer Center, Boston, USA

¹King’s College London & The francis Crick Institute, London, UK

¹Netherlands Cancer Institute, Amsterdam, The Netherlands

¹Queen’s University Belfast, Belfast, Northern Ireland, UK,²Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK

¹CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK

¹Queen Mary University of London, London, UK

¹Institut Gustave Roussy and INSERM, Villejuif, France

¹Babraham Institute, Cambridge, UK,²Centre for Trophoblast Research, University of Cambridge, Cambridge, UK,³Wellcome Trust Sanger Institute, Cambridge, UK

¹Pfizer, Cambridge, MA, USA

¹Wellcome Trust Sanger Institute, Hinxton, UK

¹The Institute of Cancer Research, London, UK,²The Royal Marsden NHS Foundation Trust, London, UK

¹Wellcome Trust/ MRC Cambridge Stem Cell Institute, Cambridge, UK,²Department of Haematology University of Cambridge, Cambridge, UK

¹Univeristy of Cambridge, Cambridge, UK

¹University of Cambridge, Cambridge, UK

¹Newcastle University, Newcastle, UK

¹The Francis Crick Institute, London, UK

¹Icahn School of Medicine at Mount Sinai, New York NY, USA

¹University of Birmingham, West Midlands, UK

¹WCRF International, London, UK,²University of Southampton, Southampton, UK

¹Genome Damage and Stability Centre, Falmer, Brighton, UK

¹BC Cancer Agency Research Centre, Vancouver, BC, Canada,²University of British Columbia, Vancouver, BC, Canada