20 abstracts found.



Individual Patient Oesophageal Cancer Models for Tailored Treatment

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John H Saunders1,2,David Onion1,Matthew Dorrington1,Pamela Collier1,Simon Parsons1,2,Anna Grabowska1

1University of Nottingham, Nottingham, UK,2Nottingham University Hospitals, Nottingham, UK


Role of CCR7 in head and neck cancer.

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Haneen Basheer1,Kamyar Afarinkia1,Victoria Vinader1,Steven Shnyder1

1Institute of cancer therapeutics, University of Bradford, Bradford, UK


Vasculogenic mimicry in small-cell lung cancer

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Francesca Trapani1,Robert Metcalf1,Cassandra Hodgkinson1,Rodoslaw Polanski1,Becky Bola1,Daisuke Nonaka2,Alberto Fusi2,Lynsey Priest1,Mary J. Hendrix3,Richard Seftor3,Elisabeth Seftor3,Christopher J. Morrow1,Jenny Antonello1,Ged Brady1,Crispin Miller4,Hui Sun Leong4,Dominic Rothwell1,Fiona Blackhall2,5,Kathryn Simpson1,Caroline Dive1,5

1CRUK MI, Manchester, Lancashire, UK,2The Christie NHS Foundation Trust, Manchester, Lancashire, UK,3Stanley Manne Children’s Research Institute, Robert H Lurie Comprehensive Cancer Center, Children’s Hospital of Chicago Research Center, Chicago, Illinois, USA,4The Institute of Cancer Sciences, University of Manchester, Manchester Lancashire, UK,5Cancer Research UK Manchester UCL Lung Cancer Centre of Excellence, Manchester and London, UK


Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in small cell lung cancer

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Jakub Chudziak1,Deborah Burt1,Jenny Antonello1,Suzanne Dalby1,Dominic Rothwell1,Barbara Mesquita1,Daniel Morris1,Mahmood Ayub1,Sumitra Mohan1,Louise Carter1,2,Fiona Blackhall2,3,Caroline Dive1,Ged Brady1

1Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, Manchester, UK,2Christie NHS Foundation Trust, Manchester, UK,3Institute of Cancer Sciences, University of Manchester, Manchester, UK


Polysialyltransferase inhibition modulates tumour cell growth, migration and invasion in neuroblastoma

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Sara Elkashef1,Bradley Springett1,Virginie Viprey1,Rida Saeed1,Goreti Ribeiro Morais1,Mark Sutherland1,Paul Loadman1,Sue Burchill2,Laurence Patterson1,Steve Shnyder1,Robert Falconer1

1Institute of Cancer Therapeutics, University of Bradford, Bradford, UK,2University of Leeds, Leeds, UK


The identification and functional validation of microRNA-330-5p and microRNA-187 as regulators of sensitivity to chemoradiation therapy in oesophageal adenocarcinoma patients

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Becky Bibby1,Christopher Cawthorne1,Cian Muldoon2,John Reynolds2,Niamh Lynam-Lennon2,Stephen Maher1,2

1University of Hull, Hull, UK,2Trinity College, Dublin, Ireland


MicroRNA-31 mediates chemoresistance in malignant pleural mesothelioma via reduced cisplatin intranuclear accumulation

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Hannah Moody1,2,Michael Lind3,Stephen Maher1

1School of Biological, Biomedical and Environmental Sciences, University of Hull, Hull, UK,2Hull York Medical School, Hull, UK,3Centre for Oncology and Haemotology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Hull, UK


DNA methylation of cell-free circulating DNA and its potential as a biomarker of high grade serous ovarian cancer

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Kayleigh Davis1,Kirsty Flower1,Jane Borley1,Charlotte Wilhelm-Benartzi1,Robert Brown1

1Imperial College London, London, UK


The Warburg effect: Regulation of integrin endocytosis and function

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Abbie Mead1,Marta Rucka1,Veronika Jenei1,Jeremy P. Blaydes1,Gareth J. Thomas1

1University of Southampton, Southampton, UK


The use of Latent Class Analysis to predict cancer risk based on a panel of serum biomarkers in the Swedish AMORIS study

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Aida Santaolalla1,Anita Grigoriadis1,Ton Coolen1,Lars Holmberg1,Hans Garmo1,Niklas Hammar2,3,Håkan Malmström2,Göran Walldius2,Ingmar Jungner4,Mieke Van Hemelrijck1

1Kings College London, London, UK,2Karolinska Institutet, Stockholm, Sweden,3AstraZeneca Sverige, Gothenborg, Sweden,4Karolinska Institutet and CALAB Research, Stockholm, Sweden


Role of hypoxia-induced ADAM10 in colorectal cancer biology

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Anna Todd1,John Greenman1,Isabel Pires1

1School of Biological, Biomedical and Environmental Sciences, University of Hull, Hull, UK


Investigating the biology of high-risk medulloblastoma by targeted siRNA and whole genome CRISPR screening.

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Matthew Selby1,Peter Banks1,Ruth Cranston1,Martina Finetti1,Matthew Bashton1,Daniel Williamson1,Steven Clifford1

1Newcastle University, Newcastle Upon Tyne, UK


Role of WSB-1 in the biology of tumour hypoxia in breast cancer

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Flore-Anne Poujade1,David Ashford2,Jerry Thomas2,John Greenman1,Isabel Pires1

1Hypoxia and Tumour Microenvironment Lab, School of Biological, Biomedical and Environmental Sciences, The University of Hull, Hull, UK,2Proteomics & Analytical Biochemistry Laboratory, Technology Facility, Department of Biology, University of York, York, UK


The role of chemerin in mediating myofibroblast effects on oesophageal squamous cancer cell (OSCC) invasion

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Jothi Dinesh Kumar1,Graham J Dockray1,Andrea Varro1

1University of Liverpool, Liverpool, UK


Functional evaluation of low-frequency driver mutations in breast cancer

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Andri Leonidou1,Sarah Maguire1,Barrie Peck1,Patty Wai1,Paul Huang1,Rachael Natrajan1

1Institute of Cancer Research, London, UK


Expression of the transcription factor NFIL3 contributes to malignant B-cell survival in multiple myeloma and Hodgkin lymphomas

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Simon Brooks1,Duncan Gascoyne1,Linden Lyne1,Demin Li1,Elizabeth Soilleux1,Alison Banham1

1University of Oxford, Oxford, UK


Outcomes in stage IV non-small cell lung cancer treatment: an observational study.

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Carles Escriu1,2,Helen Wong1,Marie McKay1,Ernie Marshall1

1Clatterbridge Cancer Centre, Liverpool, UK,2University of Liverpool, Liverpool, UK


Investigating a novel ERCC5 polymorphism as a biomarker of oxaliplatin effect in patients with metastatic colorectal cancer

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Joanna Wood1,Jennifer Bowdrey1,Joanna Somers1,Anne Willis1,Anne Thomas1

1University of Leicester, Leicester, UK


Assessing the feasibility of conducting a primary chemoprevention study of curcumin in young patients with FAP

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Joanna Wood1,Lynne Howells1,Karen Brown1,Anne Thomas1

1University of Leicester, Leicester, UK


Statins as novel therapeutic agents in targeting TAMs within human NSCLC microenvironment

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Esraa Aldujaily1,Tamihiro Kamata2,David Moore 3, John LeQuesne1,3,Catrin Pritchard1,2

1Cancer Studies, University of Leicester, UK,2Biochemistry Department, University of Leicester, UK,3Toxicology Unit, University of Leicester, UK