422 abstracts found.



Epigenetic sensitization of non-small cell lung cancer to 5-Fluorouracil

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Israa Al-Humairi1
1University of LIverpool

Investigation into the Role of Protein Phosphatase 4 Regulatory Subunits in Leukaemia

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Mirna Mourtada-Maarabouni1,Mathilda Abou Faycal Abou Faycal2,Assem Elkak2,Anwar Hasan1
1Keele University,2Lebanese University

PARKIN protein expression and its impact on the survival of patients with advanced colorectal cancer

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Claudia Caroline Veloso da Silva1,Rosimeri Kuhl Svoboda Baldin2,Nayanne Louise Costacurta1,Amanda Pereira Agostinho1,Márcia Olandosk1,Lúcia de Noronha1,Vanessa Santos Sotomaior1
1Pontifícia Universidade Católica do Paraná,2Hospital de Clínicas da Universidade Federal do Paraná (HC-UFPR)

Tracking Renal Cancer Evolution reveals deterministic routes to tumour progression

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Kevin Litchfield1
1The Francis Crick Institute

Investigating the effect of combination therapy on cetuximab inhibition of epidermal growth factor receptor signalling combined with dynamin inhibition in head and neck cancer squamous cell carcinoma

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Hui Yi Chew1,Adam McCluskey2,Phillip Robinson3,Benedict Panizza4,James Wells1,Riccardo Dolcetti1,Fiona Simpson1
1The University of Queensland Diamantina Institute, Brisbane, Queensland,2Centre for Chemical Biology, Chemistry, University of Newcastle, Callaghan, NSW,3Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, NSW,4Department of ENT Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland

Effect of cAMP on the migration, proliferation, invasion and trans-endothelial migration of Neuroblastoma cells

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Rabiu Fage Inuwa1,John Quayle2,Diana Moss2
1Institute of Translational Medicine, University of Liverpool,2Department of cellular and molecular physiology, University of Liverpool

Novel method for studying the in-vitro effects of anti-cancer agents: the assay of thymidine kinase 1 (TK1) in cell culture utilising AroCell TK 210 ELISA

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Kiran Kumar Jagarlamudi1,Liya Wang2,Staffan Eriksson3
1AroCell AB www.arocell.com,2Swedish Agricultural University,3Swedish Agricultural University, AroCell AB

Apoptosis-inducing therapeuticals promote ectodomain shedding of hypoxia-regulated carbonic anhydrase IX

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Michal Pastorek1,Ivana Vidlickova2,Miriam Zatovicova2,Silvia Pastorekova2
1Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic,2Department of Molecular Medicine, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovak Republic

Reactive Oxygen Species (ROS) modulation as a strategy to improve chemo-sensitivity in homologous recombination stratified epithelial ovarian cancer

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Chandan Mondal1,Chandan Mondal2,Eswara Murali Satyavarapu3,Chitra Mandal3
1Tata Medical Center and Tata Translational Cancer Reseach Center, Kolkata,2Tata Medical Center,3CSIR-Indian Institte of Chemical Biology

Retinoid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma, breast cancer and renal carcinomas: mRNA expression pattern

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Julius Brtko1,Lucia Bialesova1,Vladimir Lenko2,Stefan Galbavy3,Jan Podoba3,Dana Macejova1
1Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava,2University Hospital, Bratislava,3Saint Elizabeth Institute of Oncology, Bratislava

Targeting FOXM1 as a therapeutic strategy in cancer

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Rebecca Downing1,Marta O. Freitas1,Wai Yiu Tse1,Sarah A. Martin1
1Barts Cancer Institute

The role of Senataxin in radiobiological hypoxia

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Shaliny Ramachandran1,Pedro Victori1,Iosifina Foskolou1,Katarzyna Leszczynska1,Kienan Savage2,Ester Hammond1
1University of Oxford,2Queen’s University Belfast

Overcoming resistance to arginine deprivation therapy in Malignant Pleural Mesothelioma

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Marta Freitas1,Peter Szlosarek1,Sarah A. Martin1
1Barts Cancer Institute

Non-Random Mis-Segregation of Human Chromosomes.

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Sarah McClelland1,Joseph Worrall2,Naoka Tamura1,Alice Mazzagatti1,Nadeem Shaikh1,Tineke van Lingen1,Bjorn Bakker3,Elina Vladimirou4,Floris Foijer3
1Barts Cancer Institute,2Barts Cancer Institute, Queen Mary University of London,3ERIBA,4UCL Cancer Institute

Can CRISPR/Cas9 screens find new synthetic lethal targets for cancer ?

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Jon Moore1
1Horizon Discovery

[10]-gingerol increases doxorubicin antitumoural and antimetastatic activity while decreases its undesired side effects in a triple negative breast cancer mouse model

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Ana Carolina Martin1,Rebeka Tomasin1,Marina Naves1,Angelica Graminha1,Liany Luna-Dulcey1,Ramon Teles1,Marcia Cominetti1
1Federal University of São Carlos

Validation of putative metastasis suppressor genes identified by an in vivo functional shRNA screen in a triple-negative breast cancer model

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Rebeka Tomasin1,Richard Redvers2,Marcia Cominetti1,Kaylene Simpson3,Robin Anderson2
1Federal University of São Carlos,2Olivia Newton John Cancer Research Institute,3Peter MacCallum Cancer Centre - Victorian Comprehensive Cancer Research Institute

A Predictive model of ‘on target’ drug resistance

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Daniel O'Neill1,Mike Firth1,Maryam Clausen1,Jonathan Wrigley1,Emanuela Cuomo1
1AstraZeneca

Development of first-in-class USP7 inhibitors using structure-based design

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Andrew Turnbull1,Stephanos Ioannidis2,Wojciech Krajewski3,Adan Pinto-Fernandez4,Claire Heride5,Agnes Martin3,Louise Tonkin3,Elizabeth Townsend2,Shane Buker2,David Lancia Jr.2,Christopher Dinsmore2,Tim Hammonds3,Sunkyu Kim2,Sylvie Urbe5,Michael Clague5,Benedikt Kessler4,David Komander6
1cancer research technology ltd,2FORMA Therapeutics,3CRUK Therapeutic Discovery Laboratories,4Oxford University,5Liverpool University,6Medical Research Council Laboratory of Molecular Biology

The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

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Sandra Van Schaeybroeck1,Nicholas Forsythe1,Alaa Refaat1,Arman Javadi1,Hajrah Khawaja1,Jessica-Ann Weir1,Heba Emam1,Wendy Allen1,Frank Burkamp2,Vlad Popovici3,Puthen Jithesh4,Claudio Isella5,Melissa Labonte1,Ian Mills1,Patrick Johnston1
1Queen's University Belfast,2Almac Discovery Laboratories,3Masarykova Univerzita,4Sidra Medical and Research Centre,5University of Torino School of Medicine

The RalB small GTPase-SEC5 effector complex regulates survival of RAS mutant colorectal cancer by regulating trafficking of DR5

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Hajrah Awais Khawaja1,Emma Evergren1,Jamie Roberts1,Daniel Longley1,Paul O'Reilly1,Darragh McArt1,Patrick Johntson1,Timothy Harrison1,Sandra Van Schaeybroeck1
1Queen's University Belfast

Human aldehyde dehydrogenase 7A1 (ALDH7A1) expression affects cancer cell proliferation, migration and cell protection against oxidative stress

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Lina Elsalem1,Anaxagoras Fotopoulos2,Simon Allison3,Jan Moreb4,Zoe Cournia2,Klaus Pors5
1Jordan University of Science and Technology,2Biomedical Research Foundation,3University of Huddersfield,4Hematological Malignancies,5University of Bradford

Genetically encoded photocrosslinking amino acids for in-cell kinase substrate identification

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Khalil Davis1,Joanna Kelly1,Silvia Martini1,Aaron Borg1,David Mann2,Alan Armstrong2,Peter Parker1
1The Francis Crick Institute,2Imperial College London

Dissecting the Ubiquitination function of the metastasis-promoting protein Podocalyxin

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Mohammed A. Mansour1
1Cancer Research UK Beatson Institute

Using the selective toxicity of the metabolite mimic dimethyl-oxalylglycine to probe the roles of alpha-ketoglutarate in cancer metabolism

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Louise Fets1,Louise Fets2,Paul Driscoll2,Patricia Nunes2,Aakriti Jain2,James MacRae2,Dimitrios Anastasiou2
1The Francis Crick Insitute,2The Francis Crick Institute

Epirubicin induced cross resistance to nucleoside analogues in prostate cancer, a study of underlying molecular mechanisms

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Moazzam Ali1,Shumaila Moazzam1
1University of the Punjab

Targeting of PRDX1 and PRDX2 in breast cancer in the context of oxidative stress

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Agata Zych1,Małgorzata Bajor2,Agnieszka Graczyk-Jarzynka2,Małgorzata Firczuk2,Jakub Gołąb2,Radosław Zagożdżon3
1Medical University of Warsaw,2Medical University of Warsaw, Department of Immunology,3Medical University of Warsaw, Department of Clinical Immunology

Effect of low power PDT and PDT combined with 5′ Aza-deoxycitidine in a murine primary breast cancer model

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Shramana Banerjee1,Soha El-Sheikh2,Rifat Hamoudi1,Pilar Acedo-Nunez1,Sweta Parker2,Amelia Meecham1,Gareth Gerrard1,Alexander MacRobert1,Mohammed Keshtgar2
1UCL,2NHS

Angiopoietin-like 2 (ANGPTL2) expression by human myxofibrosarcoma tumour cells affects their differentiation and collagen I matrix assembly in three-dimensional in vitro models.

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Matthew Morfitt1,Ava N. Van Ess1,Adam A. Moverley1,Jessica F Ferreira Gouveia1,Daiga Harlamova1,Christine Blancher2,Tony Sinclair1,Ann Lowry1,Stephen Henderson3,Leonid L. Nikitenko1
1University of Hull,2University of Oxford,3University College London

Cancer cell contractility: revealing new functions in the tumour microenvironment

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Anna Perdrix Rosell1,Victoria Sanz-Moreno2,Ilaria Malanchi1
1The Francis Crick Institute,2King's College London

The relationship between immune checkpoint activation and host inflammatory responses in colorectal cancer

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Lauren Grant1,Jean Quinn1,Campbell SD Roxburgh1,Paul G Horgan2,Donald C McMillan2,Joanne Edwards1,James H Park2
1Institute of Cancer Sciences, University of Glasgow,2Academic Unit of Surgery, School of Medicine, University of Glasgow

Targeting DNA polymerase beta (polβ) for a personalised ovarian cancer therapy

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Reem Ali1,Tarek ABDEL-FATAH1,Paul Moseley1,Emad Rakha1,Claire Seedhouse1,Srinivasan Madhusudan1
1University of nottingham

HDAC inhibitors overcome resistance to IAP inhibitors in colorectal cancer by downregulating FLIP

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Katie Stott1,Nyree Crawford1,Daniel Longley1
1CCRCB Queens University Belfast

Exploiting endogenous replication stress in cervical cancer by inhibition of checkpoint signalling

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Stuart Rundle1,Ali Kucukmetin2,Yvette Drew1,Nicola Curtin1
1Newcastle University,2Northern Gyanecological Oncology Centre

EDICT: Exercise induced changes in colorectal cancer tissue

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Andrew Bates1,Tamas Hickish1,Bryony Eccles1,Steven Williams1,Laura Purandare1,Richard Green1
1Royal Bournemouth Hospital

ELTD1 is a highly conserved, non-canonically signalling adhesion GPCR regulating NOTCH, KIT and endothelial sprouting

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David Favara1,Madhulika Nambiar2,Helen Sheldon3,Massimo Masiero4,Demin Li4,Ines Liebscher5,Ali Jazayeri2,Alison Banham4,Adrian Harris3
1,2Heptares Therapeutics, UK,3Department of Oncology, University of Oxford,4NDCLS, Radcliffe Department of Medicine, University of Oxford,5Institute of Biochemistry, Medical Faculty, University of Leipzig

Targeting the co-chaperone Bag-1L as a novel strategy to inhibit the N-terminal domain of the androgen receptor in castration resistant prostate cancer 

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Antje Neeb1,Adam Sharp1,Laura Cato2,Simone Graessle3,Ruth Riisnaes1,Daniel Nava Rodrigues1,Ines Figueiredo1,Veronica Gil1,Nane Kuznik3,Friedrich Fauser3,Till Seime4,Jacob Troppmair4,Holger Puchta3,Nicole Jung3,Stefan Braese3,Myles Brown2,Andrew C. B. Cato3,Johann de Bono1
1Institute of Cancer Research,2Dana-Farber Cancer Institute and Harvard Medical School,3Karlsruhe Institute of Technology,4Innsbruck Medical University

Labelling the metastatic niche: a unique system to characterize the niche with an unprecedented precision.

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Luigi Ombrato1,Ilaria Malanchi1
1The Francis Crick Institute

Targeting lipidation in B cell lymphoma

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Gregor Lueg1,Dinis Calado1,Ed Tate2
1The Francis Crick Institute,2Imperial College London

FLYWCH1, a novel transcription factor with tumor suppressor activity

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Sheema Almozyan1,Roya Babaei-Jadidi2,Abdolrahman S Nateri2
1University of Nottingham,2Cancer Genetics & Stem Cell Biology Group, Cancer Biology Unit, Division of Cancer & Stem Cells, School of Medicine, University of Nottingham, NG7 2UH

Identification and Abrogation of Aberrant Androgen Receptor (AR) Signalling in Metastatic Castration Resistant Prostate Cancer (CRPC).

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Adam Sharp1,Jon Welti1,Yezi Zhu2,Ines Figueiredo1,Wei Yuan1,Daniel Nava Rodrigues1,Vernonica Gil1,Mateus Crespo1,Eleanor Knight1,Jian Ning1,Jeff Francis1,Antje Neeb1,Gunther Boysen1,Amanda Swain1,Jun Luo2,Stephen Plymate3,Johann de Bono1
1Institute of Cancer Research,2John Hopkins Univeristy,3Univeristy of Washington

Architectural insights into CHFR structure and substrate recognition

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Leanna Smith1,Anja Winter2,Ralf Schmid3,Richard Bayliss4
1University of Leicester / Astbury Centre for Structural Molecular Biology (University of Leeds),2Keele University,3University of Leicester,4Astbury Centre for Structural Molecular Biology (University of Leeds)

DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells

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Ian Marc Bonapace1
1University of Insubria

Upregulation of Rab GTPase and Integrins in drug resistant cancer cell lines and their effect on cell adhesion and migration

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Zeeshan Mutahir1,Isma Umar1,Moazzam Ali1
1University of the Punjab

Multiplatform assay to classify formalin-fixed paraffin-embedded (FFPE) colorectal cancer (CRC) samples into molecular subtypes with mutational profiles

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Elisa Fontana1,Chanthirika Ragulan1,David Cunningham2,Sanna Hulkki-Wilson1,Francesco Sclafani2,Gift Nyamundanda1,Yatish Patil1,Katherine Eason1,Ruwaida Begum2,Irene Chong1,Clare Peckitt2,Maria Antonietta Bali2,Jacqueline Oates2,David Watkins2,Sheela Rao2,Michael Hubank1,Andrew Wotherspoon1,Nicola Valeri1,Ian Chau2,Naureen Starling2,Anguraj Sadanandam1
1Institute of Cancer Research,2Royal Marsden Hospital

In vitro characterisation of the functional significance of a novel USP9X-DDX3X fusion in acute lymphoblastic leukaemia

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Jasper Mogg1,Stefano Tonin2,Lisa Russell2
1Newcastle University Medical School,2Northern Institute for Cancer Research

Absence of nuclear Programmed Cell Death 4 as an indicator of poor prognosis in Uveal Melanoma patients

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Ibrar Ahmed1,Helen Kalirai2,Martina Angi1,Sarah Coupland1
1Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine,2Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Medicine

Downregulation of phospho-RPS6 by targeting VPS34 produces synthetic lethality with autophagy inhibitors in breast cancer

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Christos E Zois1,Maria Manifava2,Simon Wigfield1,Syed Haider3,Lefteris Karanasios2,Christoffer Lagerholm4,Ian Ganley5,Nicholas Ktistakis2,Adrian L Harris1
1University of Oxford, John Radcliffe Hospital, Weatherall Institute of Molecular Medicine, Department of Oncology, Molecular Oncology Laboratories, Headington,2The Babraham Institute,3University of Oxford, John Radcliffe Hospital, Weatherall Institute of Molecular Medicine, Department of Oncology, Molecular Oncology Laboratories, Headington2,4University of Oxford,5University of Dundee

A study of mRNA expression of PTK6V1 and PTKV2 in human breast cancer.

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Umar Wazir1,Hiba El Hage Chehade1,Amanda Harvey2,Christina Choy1,Abdul Kasem1,Wen Guo Jiang3,Kefah Mokbel1
1London Breast Institute,2College of Life Sciences, Brunel University.,3Cardiff China Medical Research Collaborative, Cardiff University

OTX2 Activity at Distal Regulatory Elements Shapes the Chromatin Landscape of Group 3 Medulloblastoma

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Gaylor Boulay1,Mary E. Awad1,Nicolo Riggi2,Tenley C. Archer3,Sowmya Iyer1,Wannaporn E. Boonseng1,Nikki E. Rossetti1,Beverly Naigles1,Shruthi Rengarajan1,Angela Volorio1,James C. Kim1,Jill P. Mesirov4,Pablo Tamayo5,Scott L. Pomeroy3,Martin J. Aryee1,Miguel N. Rivera1
1Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts,2Institute of Pathology, Centre Hospitalier Universitaire Vaudois, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland,3Department of Neurology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts,4Broad Institute of Harvard and MIT, Cambridge, Massachusetts,5Broad Institute of Harvard and MIT, Cambridge, Massachusetts.