237 abstracts found.



Phenotyping neutrophil subpopulations in advanced lung cancer

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Robert Grecian1,Patricia Dos Santos Coelho1,Emily Watts1,Kev Dhaliwal1,Adam Byron1,Margaret Frame1,Moira Whyte1,Sarah Walmsley1
1Edinburgh University

Cancer Antigen Presentation in Colorectal Cancer Local Metastases

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Thomas Starkey1,Thomas Starkey1,Tessa Sanberg2,Roland Arnold1,Ian Tomlinson1,Lennard Lee1
1University of Birmingham,2Universiteit Leiden

Factor XIIIA variants ³⁴Leu and ⁶⁵⁰Ile demonstrate functional differences for ECM proteins

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Elmena Elfaki1,Aruna Asipu1,Timothy J. Perren2,Alexander F. Markham1,Rashida Anwar1
1University of Leeds,2University of Leeds / Leeds Teaching Hospitals Trust

Transcriptome-wide Mendelian randomisation identifying brain-specific causal genes influencing glioma

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Jamie Robinson1,Richard Martin1,Amy Howell1,Spiridon Tsavachidis2,Georgina Armstrong2,Caroline Relton1,Melissa Bondy2,Jie Zheng1,Kathreena Kurian1
1University of Bristol,2Baylor College of Medicine

Role of cholesterol in colon cancer and its impact on AOM/DSS induced mouse intestinal tumourigenesis

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Shyamananda Singh Mayengbam1,Manoj Kumar Bhat1
1National Centre for Cell Science, Savitribai Phule Pune University, Pune, India

Yeast orthologue mapping predicts genetic vulnerabilities in tumour cells

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Mark Wade1,Kaliya Georgieva2,Christopher Hindley1,Harpreet Saini1
1Astex Pharmaceuticals,2University of Bath

Total RET (t-RET) expression in formalin fixed paraffin embedded (FFPE) clinical breast cancer samples and correlation with co-receptors and clinical outcomes

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Zoe Hudson1,Stacie Marks1,Rob Jones1,Huw Mottram1,Pauline Finlay1,Andrew Green2,Rakha Emad2,Fouad Alchami3,Julia Gee1
1Cardiff University,2Nottingham University,3Weill Cornell Medicine

Apoptotic pancreatic cancer cells induce apoptosis in mesenchymal stromal cells

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Ester Pfeifer1,Debashis Sarker1,Joy Burchell1,Francesco Dazzi1
1King's College London

Phospho-protein arrays: a useful tool for identification of kinase inhibitors targets in personalized treatment of pediatric refractory solid tumors

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Jakub Neradil1
1Faculty of Medicine, Masaryk University

Investigating COX isoform dependency in intestinal tumourigenesis

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Noha-Ehssan Mohamed1,Rachel Ridgway1,Owen Sansom1
1Cancer Research UK Beatson Institute, Glasgow, UK

Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup – the “ATRESS” phenomenon

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Patriek Jurrius1,Thomas Green1,Hans Garmo1,Matthew Young2,Massimilano Cariati1,Cheryl Gillett1,Anca Mera1,Mark Harries2,Anita Grigoriadis1,Sarah Pinder1,Lars Holmberg1,Arnie Purushotham1
1King's College London,2Guy’s and St Thomas NHS Foundation Trust

classifieR: an interactive web interface for the molecular classification of colorectal cancer from RNA-sequencing data

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Gerard Quinn1,Tamas Sessler1,Wendy Allen1,Sarah Maguire1,Phillip Dunne1,Darragh McArt1,Harper VanSteenhouse2,Peter Gallagher1,Andrea Lees1,Dan Longley1,Bruce Seligmann2,Mark Wappett1,Simon McDade1
1Queen's University Belfast, Belfast, UK,2BioSpyder Technologies, Carlsbad, US

Role of mir-214 in modulating chemoresistance and its effect on global mRNA expression profiling in cervical cancer

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Prakriti Sen1,Niladri Ganguly2
1KIIT School Of Biotechnology,2KIIT School of Biotechnology

Adiponectin suppresses inflammasomes activation in breast cancer cells via sestrin-2 induction

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Duc-Vinh Pham1,Pawan Kumar Raut1,Ananda Baral1,Su-min Lee1,Thi-Hong-Van Tran1,Pil-Hoon Park1
1Yeungnam University

Does augmenting the complement system improve Rituximab induced cell lysis?

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Katy Plant1
1Cardiff University School of Medicine

The Roles of Gelsolin in the Regulation of Wnt Signaling in Colorectal Cancer

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Mei Shan Ong1,Shuo Deng1,Tuan Zea Tan2,Shing Chuan Hooi1,Alan Prem Kumar3,Celestial T. Yap1
1National University of Singapore,2Cancer Science Institute,3National University of Singapore, Cancer Science Institute

A CRISPR/Cas9-mediated Screening of the F-box domain-containing E3 Ligase family in Intestinal Organoids

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Hossein Kashfi1,Nicholas Jinks1,Abdolrahman Shams Nateri1
1Cancer Genetic and Stem cell group, Division of cancer and stem cell, Nottingham University

ERG promotes the methylation reprogramming in prostate cancer onset

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Maria Giovanna de Marino1
1University of Insubria

A ‘Beyond Genomics’ Approach to Precision Oncology: Development of a Protein Profiling Platform for Tumor and Tumor Organoid Samples

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Christoph Sachse1,Gerrit Erdmann1,Anja Briese1,Przemyslaw Dudys1,Ulrike Pfohl2,Markus Templin3,Christian Regenbrecht4
1NMI TT Pharmaservices,2Institute of Pathology University Clinic Magdeburg,3NMI Natural and Medical Sciences Institute at the University of Tübingen,4Institute of Pathology University Clinic Magdeburg, CELLphenomics GmbH, ASC Oncology GmbH

Metabolic functions of astrocytes are retained by glioblastoma stem-like cells and support glioblastoma growth in vivo

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Tobias Ackermann1,Maria Francesca Allega2,Anaïs Oudin3,Anna Golebiewska3,Olivier Keunen3,Simone P. Niclou3,Eyal Gottlieb2,Saverio Tardito2
1Cancer Research UK Beatson Institute,2Oncometabolism Laboratory, Cancer Research UK Beatson Institute,3NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health

ORAI2 promotes tumorigenesis and metastasis in gastric cancer via activation of the PI3K/Akt and FAK/MAPK/ERK pathways

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Shayi Wu1
1University of Hong Kong

GYS1 inhibition and synthetic lethality with mitochondrial inhibitors in breast cancer

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Ellen de Heer1,Christos E Zois1,Syed Haider2,Daniel Ebner1,Andrew Ratcliffe3,Adrian Harris1
1University of Oxford, Oxford, UK,2Institute of Cancer Research, London, UK,3Novintum Bioscience, London, UK

One-carbon metabolism and renal cell carcinoma: A systematic review and meta-analysis

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Joanna Clasen1,Alicia Heath1,David Muller1
1Imperial College London

Hedgehog signals inhibitors reverse sorafenib resistance in patient-derived organoids models with hepatocellular carcinoma

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Siqi Wang1,Jiye Zhu1,Zhao Li1,Yang Wang1
1Department of Hepatobiliary Surgery, Peking University People’s Hospital

Genetically raised serum bilirubin levels and respiratory cancer: a cohort study using UK Biobank

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Laura Horsfall1,Stephen Burgess2,Ian Hall3,Irwin Nazareth1
1University College London, London, UK,2MRC Biostatistics Unit, Cambridge, UK,3University of Nottingham, Nottingham, UK

Carbonic Anhydrase 9 Confers Resistance to Ferroptosis/Apoptosis in Malignant Mesothelioma Under Hypoxia

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Zan Li1,Li Jiang1,Shinya Toyokuni1
1Nagoya University Graduate School of Medicine

A screen for epigenetic reprogramming reveals LSD1 inhibitor as a potential intervention to promote differentiation in pancreatic cancer

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Frances Willenbrock1,James Wantling1,Eric O'Neill1
1University of Oxford, Oxford, UK

ELF3-CaM interaction promotes angiogenic activity of ovarian cancer under hypoxic conditions

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Seung Hee Seo1
1EWHA WOMANS UNIVERSITY

Protein Phosphatase 4 Regulatory Subunit 3A regulates leukemic cell survival independent of PP4 catalytic subunit

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Mirna Mourtada-Maarabouni1,Nadieh Kavousi2
1Keele University,2University of Keele

Next generation Cytogenetics: Comprehensive Structural Analysis of Cancer Genomes by Optical Genome Mapping

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Ernest Lam1,Andy Peng2,Alex Hastie1,Yannick Delpu1
1Bionano Genomics,2Bionano Genomcis

Inhibiting Ehmt2 and Ezh2 histone methyltransferases alters the immune microenvironment in a Trp53-/- murine ovarian cancer model

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Pavlina Spiliopoulou1,Sarah Spear2,Patricia Roxburgh3,Susanne Dowson4,Susan Mason4,Karen Blyth4,Matthew Fuchter2,Bob Brown2,Iain A McNeish2
1Beatson West of Scotland Cancer Centre, Glasgow, UK,2Imperial College London, London, UK,3Beatson West of Scotland Cancer Centre,4University of Glasgow, Glasgow, UK

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens nominates the Werner Syndrome RecQ helicase as a synthetic lethal target in MMR-deficient tumours

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Gabriele Picco1,Fiona M Behan1,Francesco Iorio1,Emanuel Gonçalves1,Charlotte M Beaver1,Giorgia Migliardi2,Rita Santos3,Yanhua Rao3,Francesco Sassi2,Marika Pinnelli2,Rizwan Ansari1,Sarah Harper1,David Adam Jackson1,Rebecca McRae1,Rachel Pooley1,Piers Wilkinson1,Dieudonne van der Meer1,David Dow3,Carolyn Buser-Doepner3,Andrea Bertotti2,Livio Trusolino2,Euan A. Stronach3,Julio Saez-Rodriguez4,Kosuke Yusa5,Mathew Garnett1
1Wellcome Trust Sanger Institute, Cambridge, UK,2Candiolo Cancer Institute, Strada Provinciale, Italy,3GlaxoSmithKline (GSK), London, UK,4Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany,5Stem Cell Genetics, Institute of Frontier Life and Medical Sciences, Kyoto, Japan

Characterisation of the in vivo role of Eltd1 in physiological and tumour angiogenesis using knockout mouse models.

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Dian Wang1,Koon Hwee Ang2,Massimo Masiero3,Esther Bridges2,Alison Banham3,Adrian Harris2
1University of Oxford,2Department of Oncology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, Oxfordshire, UK,3Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, Oxfordshire, UK

Oncogenic Ras/ERK signalling alters cell shape and mechanics to facilitate cell division under confinement

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Helen Matthews1,Sushila Ganguli1,Katarzyna Plak1,Anna Taubenberger2,Jochen Guck2,Buzz Baum1
1University College London,2TU Dresden

Exposure to ionizing radiation elicits significant lung tissue perturbations and creates a tumour-supportive microenvironment

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Emma Nolan1,Ilaria Malanchi1
1Francis Crick Institute

A novel role of BAP1 in regulating the spindle assembly checkpoint and mitotic spindle assembly

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Anita Singh1,Dean Fennell1,Andrew Fry1
1University of Leicester, Leicester, UK

Automated extraction and visualisation of data from the TARGET (Tumour chARacterisation to Guide Experimental Targeted therapy) trial to support interim analysis

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Paul O'Regan1,Julie Stevenson1,Donal Landers1,Matthew Krebs2,Richard Hoskins3
1Cancer Research UK,2The Christie NHS Foundation Trust,3The University of Manchester

Role of RTK/MAPK/ERK signaling in TGF-β and Activin mediated actions

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Srishti Gautam1
1Indian Institute of Science

Genome-wide CRISPR screen in 3D intestinal organoids to define novel mechanisms critical for colorectal tumorigenesis

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Patrizia Cammareri1,Eline Janssen2,Caroline Billard2,Michela Raponi2,Victoria Gudino2,Stuart Aitken2,Alfonso Bolado Carrancio2,Alex Von Kriegsheim2,Abdolrahman Nateri3,Kevin Myant2
1ECRC,2Cancer Research UK Edinburgh Centre, The Institute of Genetics and Molecular Medicine,3Cancer Biology Unit, Division of Cancer & Stem Cells. School of Medicine, University of Nottingham

Mapping Cellular Subpopulations within Triple Negative Breast Tumors Provides a Tool for Cancer Sensitization to Radiotherapy

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Ariel M. Rubinstein1,Heba Alkhatib1,Swetha Vasudevan1,Shira Stefansky1,Tamar Peretz-Yablonsky2,Avital Granit2,Amichai Meirovich2,Nataly Kravchenko-Balasha1
1Hebrew University of Jerusalem,2Hadassah Medical Center

Expression Levels of hsa-miR-590-3p in Hepatocellular Carcinoma and Osteosarcoma Cell Lines and its Downstream Target Genes

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Mennatallah Elfar1,Asma Amleh2
1Generations Labs,2The American University in Cairo

Pick-Seq®: a novel technology to retrieve tissue micro-regions for RNA sequencing

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Rebecca Podyminogin1,Nolan Ericson1,Jennifer Chow1,Jia-Ren Lin2,Yu-An Chen2,Zoltan Maliga2,Kyla Teplitz1,Tessa Pei-Ching Tsai1,Adrian Quintanilla1,Peter Sorger2,Eric Kaldjian1,Tad George1
1RareCyte, Seattle, US,2Harvard Medical School, Cambridge, US

Nischarin and ShcD interaction:  A novel mechanism to control cell migration and affecting patients’ overall survival

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Samrein Ahmed1
1University of Sharjah

Development of a medium-throughput colony formation screen for identification of novel radiosensitising drugs for glioblastoma

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Natividad Gomez-Roman1,Mark R Jackson1,Sandeep Chahal1,Anthony J Chalmers1
1University of Glasgow

Molecular and functional studies on a sub-population of T cells resistant to Galectin-9

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Thi Bao Tram Tran1,Aurore Gelin1,Philippe Rameau1,Cyril Catelain1,Valentin Baloche1,Pierre Busson1
1Gustave Roussy Institute, Villejuif, France

CD99 regulation of cancer cell dynamics and tumour formation

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Adam Odell1,Aarren Mannion2,Alison Taylor3,Pam Jones3,Graham Cook3
1York St. John University,2Karolinska Institute,3University of Leeds

Invasion by gut bacteria promotes growth in early and late stage colorectal tumour cells

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James Robson1,David Qualtrough1,Robin Thorn1
1University of the West of England

Exploration of molecular signalling underpinning the DNA Damage Response Deficiency (DDRD) assay in Colorectal Cancer; Data from the S:CORT consortium (Stratification in COlorRecTal cancer)

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Sudhir Malla1,Keara Redmond1,Andrew Blake2,Enric Domingo2,Susan Richman3,Michael Youdell2,Ian Tomlinson4,Louise Brown5,Tim Maughan2,Mark Lawler1,Philip Dunne1,S:cort Consortium6
1Queen's University Belfast, Belfast, UK,2University of Oxford, Oxford, UK,3University of Leeds, Leeds, UK,4University of Birmingham, Birmingham, UK,5University College London, London, UK,6S:CORT Consortium, Oxford, UK

Critical role of autophagy induction in tumor growth and activation of cancer metabolism by leptin in breast cancer Cells

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Nirmala Tilija Pun1,Duc-Vinh Pham1,Pawan Kumarraut1,Ananda Baral1,Su-min Lee1,Thi-Hong-Van Tran2,Pil-Hoon Park*1
1Yeungnam University,2Yeungnam Univesity

Development of a proteomics-based predictor for targeted use of IAP antagonists in colorectal cancer

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Christopher McCann1
1Queen's University Belfast