215 abstracts found.



Phenotyping neutrophil subpopulations in advanced lung cancer

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Robert Grecian1,Patricia Dos Santos Coelho1,Emily Watts1,Kev Dhaliwal1,Adam Byron1,Margaret Frame1,Moira Whyte1,Sarah Walmsley1
1Edinburgh University

Cancer Antigen Presentation in Colorectal Cancer Local Metastases

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Thomas Starkey1,Thomas Starkey1,Tessa Sanberg2,Roland Arnold1,Ian Tomlinson1,Lennard Lee1
1University of Birmingham,2Universiteit Leiden

Role of mir-214 in modulating chemoresistance and its effect on global mRNA expression profiling in cervical cancer

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Prakriti Sen1,Niladri Ganguly2
1KIIT School Of Biotechnology,2KIIT School of Biotechnology

Investigating COX isoform dependency in intestinal tumourigenesis

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Noha-Ehssan Mohamed1,Rachel Ridgway1,Owen Sansom1
1Cancer Research UK Beatson Institute, Glasgow, UK

Yeast orthologue mapping predicts genetic vulnerabilities in tumour cells

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Mark Wade1,Kaliya Georgieva2,Christopher Hindley1,Harpreet Saini1
1Astex Pharmaceuticals,2University of Bath

Total RET (t-RET) expression in formalin fixed paraffin embedded (FFPE) clinical breast cancer samples and correlation with co-receptors and clinical outcomes

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Zoe Hudson1,Stacie Marks1,Rob Jones1,Huw Mottram1,Pauline Finlay1,Andrew Green2,Rakha Emad2,Fouad Alchami3,Julia Gee1
1Cardiff University,2Nottingham University,3Weill Cornell Medicine

ERG promotes the methylation reprogramming in prostate cancer onset

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Maria Giovanna de Marino1
1University of Insubria

Metabolic functions of astrocytes are retained by glioblastoma stem-like cells and support glioblastoma growth in vivo

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Tobias Ackermann1,Maria Francesca Allega2,Anaïs Oudin3,Anna Golebiewska3,Olivier Keunen3,Simone P. Niclou3,Eyal Gottlieb2,Saverio Tardito2
1Cancer Research UK Beatson Institute,2Oncometabolism Laboratory, Cancer Research UK Beatson Institute,3NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health

Invasive breast cancer over four decades reveals persisting poor metastatic outcomes in treatment resistant subgroup – the “ATRESS” phenomenon

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Patriek Jurrius1,Thomas Green1,Hans Garmo1,Matthew Young2,Massimilano Cariati1,Cheryl Gillett1,Anca Mera1,Mark Harries2,Anita Grigoriadis1,Sarah Pinder1,Lars Holmberg1,Arnie Purushotham1
1King's College London,2Guy’s and St Thomas NHS Foundation Trust

classifieR: an interactive web interface for the molecular classification of colorectal cancer from RNA-sequencing data

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Gerard Quinn1,Tamas Sessler1,Wendy Allen1,Sarah Maguire1,Phillip Dunne1,Darragh McArt1,Harper VanSteenhouse2,Peter Gallagher1,Andrea Lees1,Dan Longley1,Bruce Seligmann2,Mark Wappett1,Simon McDade1
1Queen's University Belfast, Belfast, UK,2BioSpyder Technologies, Carlsbad, US

One-carbon metabolism and renal cell carcinoma: A systematic review and meta-analysis

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Joanna Clasen1,Alicia Heath1,David Muller1
1Imperial College London

Genetically raised serum bilirubin levels and respiratory cancer: a cohort study using UK Biobank

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Laura Horsfall1,Stephen Burgess2,Ian Hall3,Irwin Nazareth1
1University College London, London, UK,2MRC Biostatistics Unit, Cambridge, UK,3University of Nottingham, Nottingham, UK

The Roles of Gelsolin in the Regulation of Wnt Signaling in Colorectal Cancer

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Mei Shan Ong1,Shuo Deng1,Tuan Zea Tan2,Shing Chuan Hooi1,Alan Prem Kumar3,Celestial T. Yap1
1National University of Singapore,2Cancer Science Institute,3National University of Singapore, Cancer Science Institute

A CRISPR/Cas9-mediated Screening of the F-box domain-containing E3 Ligase family in Intestinal Organoids

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Hossein Kashfi1,Nicholas Jinks1,Abdolrahman Shams Nateri1
1Cancer Genetic and Stem cell group, Division of cancer and stem cell, Nottingham University

ELF3-CaM interaction promotes angiogenic activity of ovarian cancer under hypoxic conditions

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Seung Hee Seo1
1EWHA WOMANS UNIVERSITY

Next generation Cytogenetics: Comprehensive Structural Analysis of Cancer Genomes by Optical Genome Mapping

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Ernest Lam1,Andy Peng2,Alex Hastie1,Yannick Delpu1
1Bionano Genomics,2Bionano Genomcis

ORAI2 promotes tumorigenesis and metastasis in gastric cancer via activation of the PI3K/Akt and FAK/MAPK/ERK pathways

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Shayi Wu1
1University of Hong Kong

GYS1 inhibition and synthetic lethality with mitochondrial inhibitors in breast cancer

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Ellen de Heer1,Christos E Zois1,Syed Haider2,Daniel Ebner1,Andrew Ratcliffe3,Adrian Harris1
1University of Oxford, Oxford, UK,2Institute of Cancer Research, London, UK,3Novintum Bioscience, London, UK

Characterisation of the in vivo role of Eltd1 in physiological and tumour angiogenesis using knockout mouse models.

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Dian Wang1,Koon Hwee Ang2,Massimo Masiero3,Esther Bridges2,Alison Banham3,Adrian Harris2
1University of Oxford,2Department of Oncology, University of Oxford, John Radcliffe Hospital, Headington, Oxford, Oxfordshire, UK,3Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, Oxfordshire, UK

Exposure to ionizing radiation elicits significant lung tissue perturbations and creates a tumour-supportive microenvironment

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Emma Nolan1,Ilaria Malanchi1
1Francis Crick Institute

Carbonic Anhydrase 9 Confers Resistance to Ferroptosis/Apoptosis in Malignant Mesothelioma Under Hypoxia

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Zan Li1,Li Jiang1,Shinya Toyokuni1
1Nagoya University Graduate School of Medicine

A screen for epigenetic reprogramming reveals LSD1 inhibitor as a potential intervention to promote differentiation in pancreatic cancer

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Frances Willenbrock1,James Wantling1,Eric O'Neill1
1University of Oxford, Oxford, UK

Role of RTK/MAPK/ERK signaling in TGF-β and Activin mediated actions

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Srishti Gautam1
1Indian Institute of Science

PIK3CA and KRAS co-activation synergise to promote prostate cancer progression

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Helen Pearson1,Christina Fennell2,Karen Montgomery2,Wayne Phillips2
1Cardiff University,2Peter MacCallum Cancer Centre

Inhibiting Ehmt2 and Ezh2 histone methyltransferases alters the immune microenvironment in a Trp53-/- murine ovarian cancer model

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Pavlina Spiliopoulou1,Sarah Spear2,Patricia Roxburgh3,Susanne Dowson4,Susan Mason4,Karen Blyth4,Matthew Fuchter2,Bob Brown2,Iain A McNeish2
1Beatson West of Scotland Cancer Centre, Glasgow, UK,2Imperial College London, London, UK,3Beatson West of Scotland Cancer Centre,4University of Glasgow, Glasgow, UK

Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens nominates the Werner Syndrome RecQ helicase as a synthetic lethal target in MMR-deficient tumours

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Gabriele Picco1,Fiona M Behan1,Francesco Iorio1,Emanuel Gonçalves1,Charlotte M Beaver1,Giorgia Migliardi2,Rita Santos3,Yanhua Rao3,Francesco Sassi2,Marika Pinnelli2,Rizwan Ansari1,Sarah Harper1,David Adam Jackson1,Rebecca McRae1,Rachel Pooley1,Piers Wilkinson1,Dieudonne van der Meer1,David Dow3,Carolyn Buser-Doepner3,Andrea Bertotti2,Livio Trusolino2,Euan A. Stronach3,Julio Saez-Rodriguez4,Kosuke Yusa5,Mathew Garnett1
1Wellcome Trust Sanger Institute, Cambridge, UK,2Candiolo Cancer Institute, Strada Provinciale, Italy,3GlaxoSmithKline (GSK), London, UK,4Institute for Computational Biomedicine, Heidelberg University, Heidelberg, Germany,5Stem Cell Genetics, Institute of Frontier Life and Medical Sciences, Kyoto, Japan

Development of a medium-throughput colony formation screen for identification of novel radiosensitising drugs for glioblastoma

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Natividad Gomez-Roman1,Mark R Jackson1,Sandeep Chahal1,Anthony J Chalmers1
1University of Glasgow

The gut microbiome and response to neoadjuvant chemotherapy in breast cancer

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Kirsty Ross1,Rodanthi Papadopoulou2,Ben Nichols2,Martin Macleod1,Judith Fraser1,Sophie Barrett1,Jeff Evans2,Konstantinos Gerasimidis2,Iain Macpherson3
1Beatson West of Scotland Cancer Centre, Glasgow, UK,2University of Glasgow, Glasgow, UK,3Beatson West of Scotland Cancer Centre, Glasgow, UK, University of Glasgow, Glasgow, UK

A novel role of BAP1 in regulating the spindle assembly checkpoint and mitotic spindle assembly

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Anita Singh1,Dean Fennell1,Andrew Fry1
1University of Leicester, Leicester, UK

Automated extraction and visualisation of data from the TARGET (Tumour chARacterisation to Guide Experimental Targeted therapy) trial to support interim analysis

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Paul O'Regan1,Julie Stevenson1,Donal Landers1,Matthew Krebs2,Richard Hoskins3
1Cancer Research UK,2The Christie NHS Foundation Trust,3The University of Manchester

Development of a proteomics-based predictor for targeted use of IAP antagonists in colorectal cancer

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Christopher McCann1
1Queen's University Belfast

Exploring metastatic dormancy to tackle breast cancer metastasis

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Stefania Di Blasio1,Laurie J Gay1,Ilaria Malanchi1
1The Francis Crick Institute

Expression Levels of hsa-miR-590-3p in Hepatocellular Carcinoma and Osteosarcoma Cell Lines and its Downstream Target Genes

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Mennatallah Elfar1,Asma Amleh2
1Generations Labs,2The American University in Cairo

Pick-Seq®: a novel technology to retrieve tissue micro-regions for RNA sequencing

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Rebecca Podyminogin1,Nolan Ericson1,Jennifer Chow1,Jia-Ren Lin2,Yu-An Chen2,Zoltan Maliga2,Kyla Teplitz1,Tessa Pei-Ching Tsai1,Adrian Quintanilla1,Peter Sorger2,Eric Kaldjian1,Tad George1
1RareCyte, Seattle, US,2Harvard Medical School, Cambridge, US

Identification of novel HNF1B mRNA splicing variants and their qualitative and semi-quantitative profile in selected healthy and tumor tissues

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Jan Hojny1,Nikola Hajkova1,Michaela Bartu1,Pavel Dundr1,Ivana Ticha1
1Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague

Delineating how PIK3CA mutation and PTEN deletion contribute to prostate cancer

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Manisha Dass1,Helen Pearson1,Matthew Smalley1,Richard Clarkson1,Wayne Phillips2,Jason Li2
1European Cancer Stem Cell Research Insititute, Cardiff University,2Peter MacCallum Cancer Centre, Melbourne

Uncovering the long tail of oesophageal cancer driver genes for patient stratification

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Lorena Benedetti1,Thanos Mourikis1,Elisabeth Foxall1,Damjan Temelkovski1,Joel Nulsen1,Juliane Perner2,Matteo Cereda3,Christopher Yau4,Rebecca Fitzgerald2,Michael Howell1,Paola Scaffidi1,Francesca Ciccarelli1
1The Francis Crick Institute, London, UK,2University of Cambridge, Cambridge, UK,3Italian Institute for Genomic Medicine, Torino, Italy,4University of Birmingham, Birmingham, UK

Invasion by gut bacteria promotes growth in early and late stage colorectal tumour cells

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James Robson1,David Qualtrough1,Robin Thorn1
1University of the West of England

Exploration of molecular signalling underpinning the DNA Damage Response Deficiency (DDRD) assay in Colorectal Cancer; Data from the S:CORT consortium (Stratification in COlorRecTal cancer)

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Sudhir Malla1,Keara Redmond1,Andrew Blake2,Enric Domingo2,Susan Richman3,Michael Youdell2,Ian Tomlinson4,Louise Brown5,Tim Maughan2,Mark Lawler1,Philip Dunne1,S:cort Consortium6
1Queen's University Belfast, Belfast, UK,2University of Oxford, Oxford, UK,3University of Leeds, Leeds, UK,4University of Birmingham, Birmingham, UK,5University College London, London, UK,6S:CORT Consortium, Oxford, UK

How does insulin exposure affect tumour cell metabolism at different stages of colorectal carcinogenesis?

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Amy Holt1,Aleksandra Ryk1,Danny Legge1,Caroline Bull1,Tracey Collard1,Ann Williams1,Emma Vincent1
1University of Bristol

Oncogenic Ras/ERK signalling alters cell shape and mechanics to facilitate cell division under confinement

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Helen Matthews1,Sushila Ganguli1,Katarzyna Plak1,Anna Taubenberger2,Jochen Guck2,Buzz Baum1
1University College London,2TU Dresden

Stratification in COloRectal cancer: from biology to Treatment prediction (S:CORT) – Transcriptional profiling of RNA from FFPE tissue

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Keara Redmond1,Susan Richman2,Andrew Blake3,Enric Domingo3,Michael Youdell3,Tim Maughan3,Mark Lawler1,Philip Dunne1
1Queen's University Belfast,2University of Leeds,3University of Oxford

Roles of EZH2 and KDM6B during EMT

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Camille Lachat1,Amandine Etcheverry2,Marc Aubry2,Jean Mosser2,Michael Herfs3,Jean-Paul Feugeas4,Michael Boyer-Guittaut4,Paul Peixoto5,Eric Hervouet5
1INSERM UMR1098,2CHU Rennes, Service de Génétique Moléculaire et Génomique, Rennes F-35033, France ; CNRS, UMR 6290, Institut de Génétique et Développement de Rennes (IGDR), Rennes F-35043, France ; Université Rennes1, UEB, UMS 3480 Biosit, Faculté de Médecine, Rennes F-35043, France ; Plate-forme Génomique Environnementale et Humaine Biosit, Université Rennes1, Rennes F-35043, France,3Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium,4Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France,5Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et Génique, F-25000 Besançon, France ; EPIGENEXP Platform, University of Bourgogne Franche-Comté, F-25000 Besançon, France

Deciphering the molecular signalling underpinning early-dissemination and metastasis from stage I colorectal cancer

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Philip Dunne1,Maurice Loughrey2,Helen Coleman2,Aoife McCooey2,Susan Richman3,Andrew Blake4,Keara Redmond2,Dion Morton5,Ian Tomlinson5,Simon Leedham4,Rachael McBride2,Jeffrey Campbell2,Tim Maughan4,Mark Lawler2,S:cort Consortium6
1Centre for Cancer Research & Cell Biology Queen's University Belfast, Belfast, UK ,2Queen's University Belfast, Belfast, UK,3University of Leeds, Leeds, UK,4University of Oxford, Oxford, UK,5University of Birmingham, Birmingham, UK,6S:CORT Consortium, Oxford, UK

MDM2 antagonists synergize with Trametinib in well-differentiated/dedifferentiated liposarcomas.

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Shomereeta Roy1,Audrey Laroche1,Stephanie Verbeke1 Verbeke1,Antoine Italiano1
1INSTITUTE OF BERGONIE, BORDEAUX

Molecular and functional studies on a sub-population of T cells resistant to Galectin-9

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Thi Bao Tram Tran1,Aurore Gelin1,Philippe Rameau1,Cyril Catelain1,Valentin Baloche1,Pierre Busson1
1Gustave Roussy Institute, Villejuif, France

The effect of combined FOLFOX with metformin in colorectal cancer cell

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Jaw Yuan Wang1,Jaw Yuan Wang2
1Kaohsiung Medical University Hospital, Kaohsiung Medical University,2Kaohsiung Medical University and Hospital

The p53/p21 axis suppresses 5FU-induced, ATM/ATR-STAT3-mediated activation of PD-L1

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Tamas Sessler1,Fiammetta Falcone2,Peter Gallagher2,Daniel Longley2,Simon McDade2
1Centre for Cancer Research & Cell Biology Queen's University Belfast, Belfast, UK, Forensic Geoscience Group Queen's University Belfast, Belfast, UK,2Queen's University Belfast, Belfast, UK

The novel CYRI protein family cooperatively modulates cancer cell migration and invasion via endocytosis of Integrins

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Anh Hoang Le1,Tamas Yelland1,Nikki Paul1,Peter Thomason1,Vasileios Paparazalou1,Loic Fort2,Andrea Berry3,Savvas Nikolaou1,Sue Burchill4,Shehab Ismail1,Robert Insall1,Laura Machesky1
1CRUK Beatson Institute,2Vanderbilt University, School of Medicine,3Leeds Institute of Medical Research at St James’s,4Leeds Institute of Cancer and Pathology

Nr4a1-loss causes an acceleration of Myc-driven lymphomagenesis and an induction of gene of the B7-CD28

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Alexander Deutsch1,Katrin Pansy1,Christine Beham-Schmid1,Andreas Prokesch1,Julia Feichtinger1
1Medical University of Graz, Graz, Austria