215 abstracts found.



CUTseq is a versatile method for preparing multiplexed DNA sequencing libraries from low-input samples

Year:

Session type:

Theme:

Xiaolu Zhang1,Silvano Garnerone1,Michele Simonetti1,Marcin Nicoś1,Luuk Harbers1,Caterina Marchiò2,Reza Mirzazadeh1,Tiziana Venesio2,Anna Sapino2,Johan Hartman1,Magda Bienko1,Nicola Crosetto1
1Karolinska Institutet,2Candiolo Cancer Institute

Loss of BCL-3 expression increases sensitivity to irradiation induced DNA damage in colorectal cancer cells

Year:

Session type:

Theme:

Christopher Parker1,Adam Chambers1,Ann Williams1
1University of Bristol, Bristol, UK

Comprehensive evaluation of mutation spectra detected in primary cutaneous melanomas including the identification of novel loss-of-function mutants

Year:

Session type:

Theme:

Nikola Hájková1
1Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague

Phenotype dictates outcome in synchronously resected primary colorectal tumours and matched liver metastases

Year:

Session type:

Theme:

Kathryn Pennel1,Colin Steele1,Antonia Roseweir1,Rene Jackstadt2,Colin Nixon2,Xabier Cortes-Lavaud2,Campbell Roxburgh1,Hester van Wyk1,Donald McMillan1,Paul Horgan1,Owen Sansom2,Joanne Edwards1
1University of Glasgow, Glasgow, UK,2Cancer Research UK Beatson Institute, Glasgow, UK

Identification of breast cancer predisposition genes through integration of tumour sequencing and case-control analyses

Year:

Session type:

Theme:

Ian Campbell1,Na Li1,Belle Lim1,Simone McInerny1,Magnus Zethoven1,Dane Cheasley1,Paul James1
1Peter MacCallum Cancer Centre

FGF1 and HSP27 Interact to Modulate the DNA Damage Response in Chemoresistant Ovarian Cancer Cells

Year:

Session type:

Theme:

Hugh A. Nicholson1,Michelle J. Ferguson2,Gillian Smith1
1University of Dundee,2NHS Tayside

Correlation of Cancer Stem Cell Markers ITGA6 and ALDH1 with Mammosphere Formation in Breast Cancer

Year:

Session type:

Theme:

Kristin Manor1,Simon Timbrell2,Robert Clarke3,Nigel Bundred2
1University of Manchester,2University Hospital of South Manchester,3Manchester Breast Centre, Division of Cancer Sciences, University of Manchester

A potent synergy between FOXG1 overexpression and Wnt signaling drives cell cycle re-entry in quiescent glioblastoma stem cells

Year:

Session type:

Theme:

Faye Robertson1,Eoghan O'Duibhir1,Harry Bulstrode2,Steve Pollard1
1University of Edinburgh, Edinburgh, UK,2University of Cambridge, Cambridge, UK

Investigating the importance of BCL-3/β-catenin signalling in colorectal tumorigenesis

Year:

Session type:

Theme:

Penny Timms1,Danny Legge1,Tracey Collard1,Adam Chambers1,Ann Williams1
1University of Bristol

Re-audit on screen failures in early phase cancer clinical trials; a single institution experience

Year:

Session type:

Theme:

Sreeja Aruketty1,Joanna Clarke2,Daniel Lovelle Gomez2,Dilshad Chang2,Alison White2,Matthew Krebs2,Louise Carter2,Donna Graham2,Shaun Villa2,Fiona Thistlethwaite2,Amanda Rees2,Natalie Cook2
1Experimental Cancer Medicine Team, The Christie NHS Trust,2Experimental Cancer Medicine Team, The Christie NHS Foundation Trust

Factor XIIIA variants ³⁴Leu and ⁶⁵⁰Ile demonstrate functional differences for ECM proteins

Year:

Session type:

Theme:

Elmena Elfaki1,Aruna Asipu1,Timothy J. Perren2,Alexander F. Markham1,Rashida Anwar1
1University of Leeds,2University of Leeds / Leeds Teaching Hospitals Trust

Activation of HER2-ELF3-KRAS axis specifically deteriorates KRASG13D mutant colorectal cancer

Year:

Session type:

Theme:

Soo-Yeon Hwang1
1Ewha Womans University

Defining the role of AP-1 in molecular adaptation to hypoxia in colorectal cancer

Year:

Session type:

Theme:

Eric VANCAUWENBERGHE1,Hannah Bolland2,Christopher Carroll2,Leonardo Da Motta2,Anna Grabowska3,Francesca Buffa4,Adrian Harris5,Alan McIntyre2
1Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,2Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,3Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham, Medical School, Queen's Medical Centre, Nottingham, UK,4Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford, Oxford, UK,5Molecular Oncology Laboratories, Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

Evaluating kinome-wide resistance mechanisms to 3rd generation EGFR inhibitors

Year:

Session type:

Theme:

Emma Fairweather1,Patrick Eyers1
1University of Liverpool

Apoptotic pancreatic cancer cells induce apoptosis in mesenchymal stromal cells

Year:

Session type:

Theme:

Ester Pfeifer1,Debashis Sarker1,Joy Burchell1,Francesco Dazzi1
1King's College London

Role of cholesterol in colon cancer and its impact on AOM/DSS induced mouse intestinal tumourigenesis

Year:

Session type:

Theme:

Shyamananda Singh Mayengbam1,Manoj Kumar Bhat1
1National Centre for Cell Science, Savitribai Phule Pune University, Pune, India

Role of IKKα andIKKα phosphorylation in patients with ER positive early-stage invasive breast cancer

Year:

Session type:

Theme:

Phungern Khongthong1,Jean Quinn1,Lindsay Bennett2,Antonia Roseweir1,Joanne Edwards1
1University of Glasgow,2University of

Reduced resident intestinal myelomonocytic cells during ApcMin/+ mouse intestinal tumorigenesis

Year:

Session type:

Theme:

Olusola Faluyi1
1Clatterbridge Cancer Centre

Loss of Retinoblastoma protein as a potential actionable event in cancer.

Year:

Session type:

Theme:

Caterina Mancusi1,John Hartley2,Sibylle Mittnacht2
1Cancer Institute UCL,2Cancer Institute-UCL

Genomic investigation of low grade serous ovarian cancer reveals unique therapeutic vulnerabilities

Year:

Session type:

Theme:

Dane Cheasley1,Anna deFazio2,Abhimanyu Nigam1,Martin Kobel3,Kylie Gorringe1,Ian G Campbell1
1Peter MacCallum Cancer Centre,2Australian Ovarian Cancer Study,3University of Calgary

Reversible inhibition of MYC translation in primary chronic lymphocytic leukaemia cells following eIF4A inhibition is associated with stabilization of MYC mRNA

Year:

Session type:

Theme:

Sarah Wilmore1,Alison Yeomans1,Sophie Marriott1,Francesco Forconi1,Freda Stevenson1,Andrew Steele1,Mark Coldwell1,Graham Packham1
1University of Southampton

Immunohistochemical Expression of Different Sub-Types of Cytokeratins by Endometrial Stromal Sarcoma

Year:

Session type:

Theme:

Iolia Akaev1,Siavash Rahimi2,Carla Marani3,Mridula Chopra1,Chit Cheng Yeoh2
1University of Portsmouth,2Portsmouth Hospitals NHS Trust,3San Carlo di Nancy Hospital

Specific features of DNA methylome in Glioblastoma Multiforme

Year:

Session type:

Theme:

Maria Eleftheriou1
1University of Nottingham

MCL-1 regulates breast cancer stem cells.

Year:

Session type:

Theme:

Kirsteen Campbell1,Karen Blyth2,Stephen Tait3
1Glasgow University/ CRUK Beatson Institute,2CRUK Beatson Institute,3Glasgow University/CRUK Beatson Institute

Detecting repeated cancer evolution from multi-region tumour sequencing data

Year:

Session type:

Theme:

Giulio Caravagna1,Ylenia Giarratano2,Daniele Ramazzotti3,Ian Tomlinson4,Trevor Graham5,Guido Sanguinetti2,Andrea Sottoriva1
1Institute of Cancer Research,2University of Edinburgh,3Stanford University,4University of Birmingham,5Barts Cancer Institute

The relationship between the immune landscape and phenotypic subtypes in patients with colorectal cancer

Year:

Session type:

Theme:

Jitwadee Inthagard1,Joanne Edwards1,Antonia Roseweir1
1University of Glasgow

Optimising analytics and visualisation for big-data in the precision medicine era.

Year:

Session type:

Theme:

Seedevi Senevirathne1,Wendy Moore1,Daniel Longley1,Darragh McArt1
1Queen's University Belfast

The study of mammary epithelial cell differentiation dynamics and breast cancer development by single cell RNA sequencing

Year:

Session type:

Theme:

Walid Khaled1,Sara Pensa2,Kyren Lazarus1,Karsten Bach3,Maria Francesca Santolla3,Jason Carroll4,David Adams5,Carlos Caldas4,John Marioni4
1University of Cambridge,2University Cambridge,3Univeristy of Cambridge,4University of Cambridge - CI,5Sanger Institute

Studying Rac1b function in colorectal cancer

Year:

Session type:

Theme:

Victoria Gudiño1,Caroline Billard1,Patrizia Cammareri1,Alex Von Kriegsheim1,Noor Gammoh1,Stuart Aitken2,John Cassidy3,Colin Nixon4,Joanne Edwards4,Graeme Murray5,Owen Sansom4,Kevin Myant1
1Cancer Research UK Edinburgh Centre,2MRC University Unit for Human Genetics,3Cancer Research UK Cambridge Institute,4Beatson Institute for Cancer Research,5University of Aberdeen

Targeting hypoxia regulated sodium driven bicarbonate transporters reduces breast cancer metastasis

Year:

Session type:

Theme:

Christopher Carroll1,Alan Mcintyre1
1University of Nottingham

Differential redistribution of transglutaminase isoforms in cisplatin resistant hepatocarcinoma (HEPG2) cells

Year:

Session type:

Theme:

Peter Coussons1,Claire Pike2,Dipak Meshram1
1Anglia Ruskin University,2Anglia Ruskin university

Defining microRNA mediated regulation of CD157 involved in colon cancer progression

Year:

Session type:

Theme:

Mahnaz Darvish Damavandi1,George Vlachogiannis2,Gift Nyamundanda2,Andrea Lampis2,Harold Parkes3,Somaieh Hedayat2,Jens Hahne2,Matteo Fassan4,Anguraj Sadanandam2,Owen Sansom5,Nicola Valeri2
1Division of Molecular Pathology, The Institute of Cancer Research, London,2The Institute of Cancer Research,3Division of Radiotherapy and Imaging, The Institute of Cancer Research, London,4Department of Medicine DIMED, University of Padova, Padova,5Cancer Research UK Beatson Institute, Glasgow

p53 activation induces targetable dependence on FLIPL.

Year:

Session type:

Theme:

Andrea Lees1,Alex McIntyre1,Fiammetta Falcone1,Tamas Sessler1,Nyree Crawford1,Gemma Gregg1,Kirsty McLaughlin1,Wendy Allen1,Caitriona Holohan1,Larry Egan2,Aideen Ryan2,Phillip Dunne1,Mark Wappet1,Patrick Johnston1,Daniel Longley1,Simon McDade1
1CCRCB Queen's University Belfast,2NUI Galway

PIXdb: Exploring the transcriptomic landscape of prostate cancer development and progression

Year:

Session type:

Theme:

Helen Ross-Adams1,Jacek Marzec1,Stefano Pirro1,Yong-Jie Lu1,Claude Chelala1
1Barts Cancer Institute, QMUL

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumour immunity.

Year:

Session type:

Theme:

Marta Canel1,David Taggart1,Norbert Kraut2,Irene C. Waizenegger2,Alan Serrels1
1University of Edinburgh,2boehringer-ingelheim

Epithelial Notch1 drives metastasis by controlling neutrophil chemotaxis in a novel late stage colorectal cancer genetically engineered mouse model

Year:

Session type:

Theme:

Rene Jackstadt1
1CRUK Beatson Institute

Vaccinia-related kinase 2 modulates role of dysbindin by regulating protein stability

Year:

Session type:

Theme:

Shin Wonsik1,Jeong Young-Hun1,Choi Jung-Hyun1,Lee Dohyun1,Kin Sangjun1,Kim Kyoung-Tai1
1POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY

circANKRD12 a potential cancer bio-marker controls cancer invasion and migration in breast and ovarian cancer cells

Year:

Session type:

Theme:

Thasni Kardeath1, Ikhlak Ahmed1, Wafaa Al Ameri1, Fatima Al-Dasim1, Joel Malek1

1weill cornell medicine- qatar


Evaluation of Tumor/Tumor Microenvironment Interactions for Potential Predictors of Patient Response to Napabucasin

Year:

Session type:

Theme:

Harry Rogoff1,An-Yun Chang1,Eric Hsu1,Jaimin Patel1,Minjie Zhang1,Haruhisa Iguchi1
1Boston Biomedical, Inc.

Notch signalling is essential for secondary senescence and confers a facultative senescence end point in primary cells

Year:

Session type:

Theme:

Tamir Chandra1,Kristina Kirschner2,Nicola Neretti3,Yee Voan Teo3,Nattaphong Rattanavirotkul1,Thomas G. Bird4,Christos Kiourtis4,Miryam Muller4,Peter D. Adams4,Anthony R. Green5,Juan-Carlos Acosta1,Andrea Quintanilla1,Angela Salzano1,Nuria Tarrat1
1University of Edinburgh,2University of Glasgow,3Brown University,4CRUK Beatson Institute,5University of Cambridge

The genomic landscape of cutaneous squamous carcinoma identifies drivers and a novel mutational signature associated with azathioprine exposure

Year:

Session type:

Theme:

Gareth Inman1,Jun Wang2,Ai Nagano2,Ludmil Alexandrov3,Karin Purdie4,Richard Taylor1,Victoria Sherwood1,Jason Thomson4,Sarah Hogan4,Lindsay Spender1,Andrew South5,Michael Stratton6,Claude Chellala2,Catherine Harwood7,Charlotte Proby1,Irene Leigh4
1University of Dundee,2Barts Cancer Institute,3UCSD,4QMUL,5Thomas Jefferson University,6Wellcome Trust Sanger Institute,7Qmul

Regulatory heterogeneity in glioblastoma multiforme informs novel drug target discovery

Year:

Session type:

Theme:

Yunpeng Liu1,Ning Shi2,Shan He2,Michael Hemann1,Aviv Regev1
1Massachusetts Institute of Technology,2University of Birmingham

The role of ELTD1/ADGRL4 in tumour angiogenesis

Year:

Session type:

Theme:

Koon Hwee Ang1
1University of Oxford

Disulfiram suppresses malignant mesothelioma in vitro and in vivo by targeting hypoxia induced NF-kB pathway and cancer stem cells

Year:

Session type:

Theme:

Vinodh Kannappan1,Zaixing Zhang2,Hemapriya Mahendran3,Gowtham Rajendran3,Peng Liu4,Yaohe Wang4,Peter Szlosarek4,Zhipeng Wang2,Michael Antonysamy3,Weiguang Wang2
1University of Wolverhampton,2Research Institute in Healthcare Science, Faculty of Science & Engineering, University of Wolverhampton,3PSG College of Arts and Science, Coimbatore, Tamilnadu, India,4Barts Cancer Institute, Queen Mary University of London

Transcriptomic data reveal the prognostic and biological significance of the Vitamin D Receptor (VDR) via pro-immune and anti-proliferative mechanisms in a cohort of 703 primary melanomas

Year:

Session type:

Theme:

Sathya Muralidhar1,Julia Newton-Bishop1,Timothy Bishop1,David Adams2,Louise Van Der Weyden2,Jeremie Nsengimana1,Jonathan Laye1,Juliette Randerson-Moor1,Joanna Pozniak1,Joey Mark Diaz1
1University of Leeds,2Wellcome Sanger Institute

Fine mapping the association between the Major Histocompatibility Complex and Barrett’s oesophagus/Oesophageal adenocarcinoma

Year:

Session type:

Theme:

Laura Chegwidden1,Johannes Schumacher2,Rebecca Fitzgerald3,Thomas Vaughan4,Stuart MacGregor5,Puya Gharahkhani5,Janusz Jankowski6,Ian Tomlinson1,Claire Palles1
1Institute of Cancer and Genomic Sciences, University of Birmingham,2University of Bonn,3Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research Centre and University of Cambridge,4Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,5QIMR Berghofer Medical Research Institute,6The Royal College of Surgeons Ireland and The University Hospitals of Morecambe Bay Hospitals NHS Trust

Identifying research priorities in HPB cancer surgery: a modified Delphi process

Year:

Session type:

Theme:

Samir Pathak1,Stephen Knight2,Alan Christie3,Louise Jones4,Jonathan Rees5,Ewen Harrison6,Mark Taylor7
1Bristol Royal Infirmary,2Usher Institute, University of Edinburgh,3Royal Infirmary of Edinburgh,4University Hospital Aintree,5bristol Royal Infirmary,6Usher Institure, University of Edinburgh,7Mater Hospital

Development of lung metastases in new animal models of OSCC

Year:

Session type:

Theme:

Sabrina Marcazzan1,Ali Dadbin2,Giulia Brachi3,Elvin Blanco2,Elena Maria Varoni1,Giovanni Lodi1,Mauro Ferrari2
1University of Milan,2Houston Methodist Research Institute,3Politecnico di Torino

Neoadjuvant endocrine therapy in breast cancer up-regulates the cytotoxic drug pump ABCG2/BCRP, and may lead to resistance to subsequent chemotherapy

Year:

Session type:

Theme:

Baek Kim1
1University of Leeds

Novel gene fusion candidates harbouring protein kinase domains in non-muscle-invasive bladder cancer (NMIBC)

Year:

Session type:

Theme:

Anshita Goel1,Douglas G. Ward1,Naheema S. Gordon1,Ben Abbotts1,Nicholas D. James1,Maurice P. Zeegers2,Kk Cheng1,Richard T. Bryan1,Roland Arnold1
1University of Birmingham,2Maastricht University, Maastricht