215 abstracts found.



BAP1 loss induces BRCA1 dependent and independent defective spindle organization, checkpoint dysfunction and genomic instability

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Anita Singh1
1university of leicester

A novel cis-acting lncRNA controls HMGA1 expression and is deregulated in non-small cell lung cancer

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Greg Stewart1,Adam Sage1,Katey Enfield1,Erin Marshall1,Victor Martinez1,Wan Lam1
1BC Cancer Research Centre

Mucinous Intestinal Tumorigenesis by Deregulation of CRAD-Controlled Cytoskeleton Dynamics

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Youn-Sang Jung1,Wenqi Wang2,Sohee Jun1,Jie Zhang1,Mrinal Srivastava1,Moon Jong Kim1,Esther Lien1,Joan Shang1,Junjie Chen1,Pierre McCrea1,Songlin Zhang3,Jae-Il Park1
1UT MD Anderson Cancer Center,2University of California, Irvine,3The University of Texas Medical School

Chemoprevention of Esophageal Cancer with esomeprazole and aspirin therapy: efficacy and safety in the phase III randomized factorial AspECT Trial

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Janusz Jankowski1,John de Caestecker2,Sharon Love3,Gavin Reilly4,Yeng Ang5,Krish Ragunath6,Art Tucker7,Ian Penman8,Colin Rodgers9,James Neale10,Claire Brooks11,Stephen Attwood12,Danielle Morris13,Rebecca Harrison14,Pradeep Bhandari15,Peter Watson16,Scott Sanders17,Hugh Barr18,Paul Moayyedi19,Aspect Trial Team20
1Royal College of Surgeons Ireland National; Institute for Health and Care Excellence; University Hospitals of Morecambe Bay NHS Trust,2University Hospitals Leicester NHS Trust,3Centre for Statistics in Medicine, University of Oxford; MRC Clinical Trials Unit,4Centre for Statistics in Medicine, University of Oxford,5Wrightington Wigan and Leigh NHS Foundation Trust,6Queen's Medical Centre, University of Nottingham,7Barts Health NHS Trust,8Western General Hospital; Royal Infirmary of Edinburgh,9Antrim Area Hospital,10Torbay and South Devon NHS Foundation Trust,11University of Oxford, Oncology Clinical Trials Office,12Durham University, School of Medicine, Pharmacy and Health,13East and North Hertfordshire NHS Trust,14UHL,15Queen Alexandra Hospital,16Queen's University Belfast Faculty of Medicine Health and Life Sciences,17South Warwickshire NHS Foundation Trust,18Gloucester Royal, Dept of Surgery,19McMaster University Medical Centre,20University of Oxford

FOS/FOSB rearrangements; defining the human bone tumour, osteoblastoma

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Matthew Fittall1,Nischalan Pillay2,Anna-Christina Strobl3,Annelien Verfaillie1,Jonas Demeulemeester1,Maxime Tarabichi4,Matthew Young5,Agamemnon Grigoriadis6,Peter Van Loo4,Peter Campbell5,Adrienne Flanagan2,Sam Behjati7
1The Francis Crick Institute,2University College London,3Royal National Orthopaedic Hospital,4The Francis Crick Institure,5Wellcome Trust Sanger Institure,6King's College London,7Wellcome Trust Sanger Institute

Deeper investigation of the metabolic subgroup in colorectal cancer

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Tessa Sandberg1,Lennard Lee1,Roland Arnold1,Ian Tomlinson1
1university of birmingham

Predicting Drug Response in Cancer in Cancer Cell Lines using Deep Learning for precision treatments

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Jyothi Deva datta reddy1,Dr.ram Reddy2,Samyukta Reddy3
1Cancer moonshot @ www.cancermoonshot.in,2Care cancer center,3CancerMoonshot

Using Genetic Barcoding to Uncover the Evolutionary Dynamics of Drug Resistance Emergence in Colorectal Cancer.

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Freddie Whiting1,Richard Nichols2,Marc Williams1,Calum Gabutt3,Ann-Marie Baker1,Trevor Graham1
1Barts Cancer Institute,2Queen Mary University of London,3UCL

Effects of GLI3 knockdown in the maintenance of stemness in oral squamous cell carcinoma

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Maria Fernanda Rodrigues1,Lucyene Miguita2,Nathália Andrade2,Fabio Nunes2
1Nove de Julho University-Post Graduate Program in Biophotonics Applied to Health Science,2Oral Pathology, School of Dentistry, University of São Paulo

Combining p53-activating agents with HDAC inhibition results in suppression of FOXM1 and other genes associated with poor prognosis prostate cancer

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Gemma Gregg1,Fiammetta Falcone1,Andrea Lees1,Gerard Quinn1,Richard Kennedy2,Ian Mills1,Simon McDade1
1Queens University Belfast,2Almac Diagnostics

Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway.

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Marianne Shawe-Taylor1
1Queen's Hospital Romford

Phenotypic Subtyping of Matched Primary Colonic Tumours and Liver Metastases

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Kathryn Pennel1,Arfon Powell2,Donald McMillan1,Paul Horgan1,Antonia Roseweir1,Joanne Edwards1
1University of Glasgow,2Cardif University

Chromosomal instability drives non-random chromosome mis-segregation

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Sarah McClelland1,Joseph Worrall1,Naoka Tamura1,Alice Mazzagatti1,Nadeem Shaikh1,Tineke van Lingen1,Bjorn Bakker2,Dinana Spierings2,Elina Vladimirou3,Floris Foijer2
1Barts Cancer Institute,2ERIBA,3UCL Cancer Institute

Clonal evolution of breast cancer treated with palbociclib and fulvestrant: a circulating tumour DNA analysis of the PALOMA-3 trial

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Ben O'Leary1,Ros Cutts1,Yuan Liu2,Sarah Hrebien1,Xin Huang2,Matthew Beaney1,Kerry Fenwick1,Fabrice Andre3,Sibylle Loibl4,Sherene Loi5,Isaac Garcia-Murillas1,Cynthia Huang Bartlett2,Massimo Cristofanilli6,Nicholas Turner7
1The Institute of Cancer Research,2Pfizer,3Institut Gustave Roussy, France,4German Breast Group,5University of Melbourne, Peter MacCallum Cancer Centre,6Robert H Lurie Comprehensive Cancer Centre, Feinberg School of Medicine,Chicago,7The Institute of Cancer Research and The Royal Marsden Hospital

Molecular mechanisms underlying phenotypic plasticity in malignant glioma

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Costanza Lo Cascio1,Ernesto Luna1,Rohit Khurana1,Roberto Fiorelli1,Shwetal Mehta1
1Barrow Neurological Institute

Characterising a novel signalling cascade involved in the development of breast cancer brain metastasis

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Chiara Galloni1,Teklu Egnuni1,Renu Gahlaut1,Michael Grant1,Valerie Speirs1,Mihaela Lorger1,Georgia Mavria1
1University of Leeds

The role of IKK-alpha in colorectal cancer

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Meera Patel1,Hannah Hood2,Jean Quinn3,Antonia Roseweir3,Arfon Powell4,Paul Horgan3,Donald McMcMillan3,Joanne Edwards1
1Institute of Cancer Sciences, University of Glasgow,2School of Medicine, University of Glasgow,3Academic Unit of Surgery, University of Glasgow,4School of Medicine, Cardiff University

Identifying Oncogenic Drivers of Poor Outcome in Triple Negative Breast Cancer

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Shannon Beattie1
1CCRCB

Maximising FLIM-FRET Biosensor Capabilities for Cancer Studies

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Kirsty Martin1
1CRUK Beatson Institute

The molecular mechanism behind PD-L1 upregulation upon 5-fluorouracil treatment in colorectal cancer cells

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Tamas Sessler1,Fiammetta Falcone2,Timothy Wright2,Peter Gallagher2,Daniel Longley3,Simon McDade2
1DRG/FGG QUB,2FGG QUB,3DRG QUB

Glycolysis supports EGFR-mutant Lung Adenocarcinoma Cell Survival by blocking Autophagy-mediated EGFR Degradation

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Wonjun Ji1,Jin Kyung Rho1,Jaekyoung Son1,Jae Cheol Lee1,Chang-Min Choi1
1Asan Medical Center

DNA replication stress generates radiation resistance in glioblastoma stem like cells

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Ross Carruthers1
1University of Glasgow

Defining novel mechanisms critical for colorectal tumourigenesis

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Patrizia Cammareri1,Caroline Billard2,Victoria Gudiño2,Kevin Myant2
1ECRC,2Cancer Research UK Edinburgh Centre

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

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Antonio Garcia-Trinidad1,Steve Durant2,Lucy Riches1,Jacqueline Fok1,Tom Hunt1,Kurt Pike2,Joanne Wilson1,Aaron Smith1,Nicola Colclough1,Venkatesh Pilla Reddy2,Andrew Sykes1,Annika Janefeldt1,Peter Johnström1,Stephanie Ling1,Jonathan Orme1,Jonathan Stott1,Caroline Roberts1,Ian Barrett1,Gemma Jones1,Martine Roudier1,Andrew Pierce1,Kristoffer Valerie3,Martin Pass1
1Astrazeneca,2AstraZeneca,3Commonwealth University

Investigating the role of dysregulated RNA splicing in colorectal cancer initiation and progression

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Adam Hall1,Kevin Myant1
1Institute of Genetics and Molecular Medicine, The University of Edinburgh

The interaction of galectin-3 with TAM receptors in activating signalling pathways for human cancer cell survival and migration.

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Nour Al Kafri1,Sassan Hafizi1
1University of Portsmouth

Investigating the relationship between proteomic and transcriptomic expression of key immune markers in HGSOC and their clinical relevance for patients.

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Laura Webster1,Manuel Salto-Tellez1,Darragh McArt1,Charlie Gourley2,Richard Kennedy1,Stephanie Craig1,Robb Hollis2,Matthew Alderdice1
1CCRCB,2University of Edinburgh

Functional Role of Circular NFATC3 in Triple Negative Breast Cancer

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Fatima Al-Dasim1,Thasni Karedath1,Stephanie Aron Ramadan1,Nayra Al-Thani1,Joel Malek1
1Weill Cornell Medicine-Qatar

Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells

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Christian Teske1,Christine Schweitzer1,Andrea Palamidessi2,Daniela Aust3,Giorgio Scita2,Jürgen Weitz1,Thilo Welsch1
1University Hospital Dresden, Dept. of Visceral, Thoracic and Vascular Surgery,2Fondazione Istituto FIRC di Oncologia Molecolare (IFOM),3University Hospital Dresden, Dept. of Pathology

Study of circulating DNA structures and origins

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Zahra Al Amir Dache1,Amaelle Otandault1,Corinne Prevostel1,Alain Thierry1
1Institut de recherche en cancérologie de montpellier

MUC1 Regulates TGF-Β Function in Pancreatic Cancer

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Priyanka Grover1,Mahboubeh Yazdanifar1,Mohammad Ahmad1,Ru Zhou1,Angat Puri1,Kajal Grover2,Xinghua Shi1,Pinku Mukherjee1
1University of North Carolina at Charlotte,2University of North Carolina at Chapel Hill

An Effective Pipeline for Whole Genome Sequencing for Research in a Tertiary Cancer Centre

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George Morrissey1,Alison Berner2,Tracy Odigie3,Alice Rendall3,Keith Rogerson3,Rahul Kurup3,Glen Brice3,Helen Hanson3,John Short3,Katie Snape3,Ruth Pettengel3,Nirupa Murugaesu2
1,2Genomics England,3St George's University Hospital NHS Trust

Oncogenic KRAS rewires translation in colorectal cancer allowing targeting via the p38/MNK/eIF4E pathway

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John Knight1,William Faller2,David Gay1,Nikola Vlahov1,Rachel Ridgway1,Christopher Proud3,Angel Nebreda4,Martin Bushell1,Anne Willis5,Owen Sansom1
1CRUK Beatson Institute,2NKI,3SAHMRI Adelaide,4IRB Barcelona,5MRC Toxicology Unit

Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis

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Madelon Paauwe1,Mark Schoonderwoerd2,Roxan Helderman2,Tom Harryvan2,Arwin Groenewoud3,Gabi van Pelt2,Rosalie Bor2,Danielle Hemmer2,Henri Versteeg2,Ewa Snaar-Jagalska3,Charles Theuer4,James Hardwick2,Cornelis Sier2,Peter ten Dijke2,Lukas Hawinkels2
1Beatson Institute for Cancer Research,2Leiden University Medical Center,3Institute of Biology, Leiden University,4Tracon Pharmaceuticals

Amino acid transporter SLC7A5 is required for growth of Kras-mutant colorectal cancer in vivo

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Arafath Najumudeen1,Fatih Ceteci1,Owen Sansom1
1Beatson Institute for Cancer Research

Bowel cancer genetics: investigating chromosomal instability by CRISPR knockout panels

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Fadipe Adetokunbo1,Lennard YW Lee2
1Merton College, Oxford,2Institute of Cancer Sciences, University of Birmingham

Analysis of proteomic changes in human breast carcinoma MDA-MB-231 cells induced by tributyltin isothiocyanate, the biologically active ligand of nuclear retinoid X receptors

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Julius Brtko1,Dana Strouhalova2,Lucia Toporova1,Dana Macejova1,Pavel Bobal3,Jan Otevrel3,Janette Bobalova2
1Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava,2Institute of Analytical Chemistry of the CAS, v. v. i., Brno,3Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno

Epigenetic inactivation of the epithelial splicing factor ESRP2 in Wilms’ tumour

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Danny Legge1,Whei Moriarty1,Sebastian Oltean2,Karim Malik1,Keith Brown1
1University of Bristol,2University of Exeter

Clinical implications of context specificity of dynamic signalling patterns in KRAS mutant cancers

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Adam Stewart1
1Institute of Cancer Research

Dysfunctional mitochondria are exported from myeloma cells to the bone marrow microenvironment

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Yu Sun1,Yu Sun1,Christopher Marlein1,Charlotte Hellmich1,Kristian Bowles1,Stuart Rushworth1
1University of East Anglia

Identification of therapeutic targets for Head and Neck Squamous Cell Carcinoma (HNSCC)

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Ahmad Malik1
1University of Toronto

eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival.

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Hannah Bolland1,Alan McIntyre1,Abdol Shams-Nateri1,Cleo Bishop2,Andrew Silver2
1University of Nottingham,2Blizzard Institute Barts and the London School of Medicine and Dentistry

Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer

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Stelios Chrysostomou1,Rajat Roy1,Filippo Prischi2,Katie Chapman3,Uwais Mufti4,Robert Peach1,Francesco Mauri1,Joel Abrahams1,Eric Aboagye1,Maruf Ali1,Michael Seckl1,Olivier Pardo1
1Imperial College London,2University of Essex,3Assay Biology, Domainex Ltd,4Department of Urology, Leeds Teaching Hospitals NHS Trust

Precision therapy in the p53 pathway

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Chit Fang Cheok1,Luis Coronel2,Ramesh Kumar3,Bhagi Somalanka3,Raju Anandh1,Obed Aning4,Ping Yin Hor5,An Omer6,Yingswan Ho7,Chen Shuwen7,Shi Ya Mak7,Henry Yang8,Mani LAKSHMANAN4,Hideki Itoh9,Soo Yong Tan10,Timothy Lim11,Adele Wong11,Sung Hock Chew11,The Hung Huynh12,Boon Cher Goh13,Vinay Tergoankar4,Chin Yan Lim9
1Institute of Molecular and Cell Biology (IMCB), A*STAR,2p53Laboratory, A*STAR,3IFOM-p53Lab JRL,4Institute of Molecular and Cell Biology (IMCB),5IFOM-p53Lab, A*STAR,6Cancer Science Institut, NUS,7Bioprocessing Technology Institute, A*STAR,8Cancer Science Institute, NUS,9Institute of Medical Biology, A*STAR,10Department of Pathology, NUS,11KK Women’s and Children’s Hospital,12National Cancer Center Singapore,13National University Cancer Institute

A Living Biobank Of Ovarian Cancer Ex Vivo Models Reveals Profound Mitotic Heterogeneity

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Stephen Taylor1
1University of Manchester

Fibroblast growth factor signalling influences platinum chemoresistance in ovarian cancer by altering both epithelial-to-mesenchymal transition and the DNA damage response

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Hugh Nicholson1,Francesco Rao2,Gillian Smith1
1University of Dundee,2DC Biosciences Ltd.

Ciz1 accumulation is regulated by opposing cyclin dependent kinase (CDK) and ubiquitin-proteasome system (UPS) activities

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Tekle Pauzaite1
1Lancaster University

Genomic analysis of Malaysian breast cancers unravel molecular differences from Caucasian breast cancers

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Muhammad Mamduh Ahmad Zabidi1,Jia Wern Pan1,Patsy Pei Sze Ng1,Mei Yee Meng1,Stephen-John Sammut2,Oscar Rueda2,Carlos Caldas2,Suet-Feung Chin2,Soo-Hwang Teo1
1Cancer Research Malaysia,2Cancer Research UK Cambridge Institute

An Immunoscore for Ovarian Cancer: Preliminary Evidence for Predicting the Ability to Expand Tumour-Infiltrating Lymphocytes from Surgical Biopsies

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James Platt1,Gemma Owens1,Richard Edmondson2
1The University of Manchester,2The University of MAnchester

Defining the role of FOSL2 in molecular adaptation to hypoxia in colorectal cancer

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Eric VANCAUWENBERGHE1,Hannah Bolland1,Christopher Carroll1,Leonardo Da Motta1,Victoria Wright2,Nadine Holmes2,Francesca Buffa3,Anna Grabowska4,Adrian Harris5,Alan McIntyre6
1Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,2Deep Seq, School of Life Sciences, University of Nottingham,3Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford,4Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,5Molecular Oncology Laboratories, Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford,6University of Nottingham