237 abstracts found.



Studying Rac1b function in colorectal cancer

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Victoria Gudiño1,Caroline Billard1,Patrizia Cammareri1,Alex Von Kriegsheim1,Noor Gammoh1,Stuart Aitken2,John Cassidy3,Colin Nixon4,Joanne Edwards4,Graeme Murray5,Owen Sansom4,Kevin Myant1
1Cancer Research UK Edinburgh Centre,2MRC University Unit for Human Genetics,3Cancer Research UK Cambridge Institute,4Beatson Institute for Cancer Research,5University of Aberdeen

Targeting hypoxia regulated sodium driven bicarbonate transporters reduces breast cancer metastasis

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Christopher Carroll1,Alan Mcintyre1
1University of Nottingham

Differential redistribution of transglutaminase isoforms in cisplatin resistant hepatocarcinoma (HEPG2) cells

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Peter Coussons1,Claire Pike2,Dipak Meshram1
1Anglia Ruskin University,2Anglia Ruskin university

Defining microRNA mediated regulation of CD157 involved in colon cancer progression

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Mahnaz Darvish Damavandi1,George Vlachogiannis2,Gift Nyamundanda2,Andrea Lampis2,Harold Parkes3,Somaieh Hedayat2,Jens Hahne2,Matteo Fassan4,Anguraj Sadanandam2,Owen Sansom5,Nicola Valeri2
1Division of Molecular Pathology, The Institute of Cancer Research, London,2The Institute of Cancer Research,3Division of Radiotherapy and Imaging, The Institute of Cancer Research, London,4Department of Medicine DIMED, University of Padova, Padova,5Cancer Research UK Beatson Institute, Glasgow

p53 activation induces targetable dependence on FLIPL.

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Andrea Lees1,Alex McIntyre1,Fiammetta Falcone1,Tamas Sessler1,Nyree Crawford1,Gemma Gregg1,Kirsty McLaughlin1,Wendy Allen1,Caitriona Holohan1,Larry Egan2,Aideen Ryan2,Phillip Dunne1,Mark Wappet1,Patrick Johnston1,Daniel Longley1,Simon McDade1
1CCRCB Queen's University Belfast,2NUI Galway

PIXdb: Exploring the transcriptomic landscape of prostate cancer development and progression

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Helen Ross-Adams1,Jacek Marzec1,Stefano Pirro1,Yong-Jie Lu1,Claude Chelala1
1Barts Cancer Institute, QMUL

T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumour immunity.

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Marta Canel1,David Taggart1,Norbert Kraut2,Irene C. Waizenegger2,Alan Serrels1
1University of Edinburgh,2boehringer-ingelheim

Epithelial Notch1 drives metastasis by controlling neutrophil chemotaxis in a novel late stage colorectal cancer genetically engineered mouse model

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Rene Jackstadt1
1CRUK Beatson Institute

Vaccinia-related kinase 2 modulates role of dysbindin by regulating protein stability

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Shin Wonsik1,Jeong Young-Hun1,Choi Jung-Hyun1,Lee Dohyun1,Kin Sangjun1,Kim Kyoung-Tai1
1POHANG UNIVERSITY OF SCIENCE AND TECHNOLOGY

circANKRD12 a potential cancer bio-marker controls cancer invasion and migration in breast and ovarian cancer cells

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Thasni Kardeath1, Ikhlak Ahmed1, Wafaa Al Ameri1, Fatima Al-Dasim1, Joel Malek1

1weill cornell medicine- qatar

Evaluation of Tumor/Tumor Microenvironment Interactions for Potential Predictors of Patient Response to Napabucasin

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Harry Rogoff1,An-Yun Chang1,Eric Hsu1,Jaimin Patel1,Minjie Zhang1,Haruhisa Iguchi1
1Boston Biomedical, Inc.

Notch signalling is essential for secondary senescence and confers a facultative senescence end point in primary cells

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Tamir Chandra1,Kristina Kirschner2,Nicola Neretti3,Yee Voan Teo3,Nattaphong Rattanavirotkul1,Thomas G. Bird4,Christos Kiourtis4,Miryam Muller4,Peter D. Adams4,Anthony R. Green5,Juan-Carlos Acosta1,Andrea Quintanilla1,Angela Salzano1,Nuria Tarrat1
1University of Edinburgh,2University of Glasgow,3Brown University,4CRUK Beatson Institute,5University of Cambridge

The genomic landscape of cutaneous squamous carcinoma identifies drivers and a novel mutational signature associated with azathioprine exposure

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Gareth Inman1,Jun Wang2,Ai Nagano2,Ludmil Alexandrov3,Karin Purdie4,Richard Taylor1,Victoria Sherwood1,Jason Thomson4,Sarah Hogan4,Lindsay Spender1,Andrew South5,Michael Stratton6,Claude Chellala2,Catherine Harwood7,Charlotte Proby1,Irene Leigh4
1University of Dundee,2Barts Cancer Institute,3UCSD,4QMUL,5Thomas Jefferson University,6Wellcome Trust Sanger Institute,7Qmul

Regulatory heterogeneity in glioblastoma multiforme informs novel drug target discovery

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Yunpeng Liu1,Ning Shi2,Shan He2,Michael Hemann1,Aviv Regev1
1Massachusetts Institute of Technology,2University of Birmingham

The role of ELTD1/ADGRL4 in tumour angiogenesis

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Koon Hwee Ang1
1University of Oxford

Disulfiram suppresses malignant mesothelioma in vitro and in vivo by targeting hypoxia induced NF-kB pathway and cancer stem cells

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Vinodh Kannappan1,Zaixing Zhang2,Hemapriya Mahendran3,Gowtham Rajendran3,Peng Liu4,Yaohe Wang4,Peter Szlosarek4,Zhipeng Wang2,Michael Antonysamy3,Weiguang Wang2
1University of Wolverhampton,2Research Institute in Healthcare Science, Faculty of Science & Engineering, University of Wolverhampton,3PSG College of Arts and Science, Coimbatore, Tamilnadu, India,4Barts Cancer Institute, Queen Mary University of London

Transcriptomic data reveal the prognostic and biological significance of the Vitamin D Receptor (VDR) via pro-immune and anti-proliferative mechanisms in a cohort of 703 primary melanomas

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Sathya Muralidhar1,Julia Newton-Bishop1,Timothy Bishop1,David Adams2,Louise Van Der Weyden2,Jeremie Nsengimana1,Jonathan Laye1,Juliette Randerson-Moor1,Joanna Pozniak1,Joey Mark Diaz1
1University of Leeds,2Wellcome Sanger Institute

Fine mapping the association between the Major Histocompatibility Complex and Barrett’s oesophagus/Oesophageal adenocarcinoma

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Laura Chegwidden1,Johannes Schumacher2,Rebecca Fitzgerald3,Thomas Vaughan4,Stuart MacGregor5,Puya Gharahkhani5,Janusz Jankowski6,Ian Tomlinson1,Claire Palles1
1Institute of Cancer and Genomic Sciences, University of Birmingham,2University of Bonn,3Medical Research Council (MRC) Cancer Unit, Hutchison-MRC Research Centre and University of Cambridge,4Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,5QIMR Berghofer Medical Research Institute,6The Royal College of Surgeons Ireland and The University Hospitals of Morecambe Bay Hospitals NHS Trust

Identifying research priorities in HPB cancer surgery: a modified Delphi process

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Samir Pathak1,Stephen Knight2,Alan Christie3,Louise Jones4,Jonathan Rees5,Ewen Harrison6,Mark Taylor7
1Bristol Royal Infirmary,2Usher Institute, University of Edinburgh,3Royal Infirmary of Edinburgh,4University Hospital Aintree,5bristol Royal Infirmary,6Usher Institure, University of Edinburgh,7Mater Hospital

Development of lung metastases in new animal models of OSCC

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Sabrina Marcazzan1,Ali Dadbin2,Giulia Brachi3,Elvin Blanco2,Elena Maria Varoni1,Giovanni Lodi1,Mauro Ferrari2
1University of Milan,2Houston Methodist Research Institute,3Politecnico di Torino

Neoadjuvant endocrine therapy in breast cancer up-regulates the cytotoxic drug pump ABCG2/BCRP, and may lead to resistance to subsequent chemotherapy

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Baek Kim1
1University of Leeds

Novel gene fusion candidates harbouring protein kinase domains in non-muscle-invasive bladder cancer (NMIBC)

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Anshita Goel1,Douglas G. Ward1,Naheema S. Gordon1,Ben Abbotts1,Nicholas D. James1,Maurice P. Zeegers2,Kk Cheng1,Richard T. Bryan1,Roland Arnold1
1University of Birmingham,2Maastricht University, Maastricht

BAP1 loss induces BRCA1 dependent and independent defective spindle organization, checkpoint dysfunction and genomic instability

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Anita Singh1
1university of leicester

A novel cis-acting lncRNA controls HMGA1 expression and is deregulated in non-small cell lung cancer

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Greg Stewart1,Adam Sage1,Katey Enfield1,Erin Marshall1,Victor Martinez1,Wan Lam1
1BC Cancer Research Centre

Mucinous Intestinal Tumorigenesis by Deregulation of CRAD-Controlled Cytoskeleton Dynamics

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Youn-Sang Jung1,Wenqi Wang2,Sohee Jun1,Jie Zhang1,Mrinal Srivastava1,Moon Jong Kim1,Esther Lien1,Joan Shang1,Junjie Chen1,Pierre McCrea1,Songlin Zhang3,Jae-Il Park1
1UT MD Anderson Cancer Center,2University of California, Irvine,3The University of Texas Medical School

Chemoprevention of Esophageal Cancer with esomeprazole and aspirin therapy: efficacy and safety in the phase III randomized factorial AspECT Trial

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Janusz Jankowski1,John de Caestecker2,Sharon Love3,Gavin Reilly4,Yeng Ang5,Krish Ragunath6,Art Tucker7,Ian Penman8,Colin Rodgers9,James Neale10,Claire Brooks11,Stephen Attwood12,Danielle Morris13,Rebecca Harrison14,Pradeep Bhandari15,Peter Watson16,Scott Sanders17,Hugh Barr18,Paul Moayyedi19,Aspect Trial Team20
1Royal College of Surgeons Ireland National; Institute for Health and Care Excellence; University Hospitals of Morecambe Bay NHS Trust,2University Hospitals Leicester NHS Trust,3Centre for Statistics in Medicine, University of Oxford; MRC Clinical Trials Unit,4Centre for Statistics in Medicine, University of Oxford,5Wrightington Wigan and Leigh NHS Foundation Trust,6Queen's Medical Centre, University of Nottingham,7Barts Health NHS Trust,8Western General Hospital; Royal Infirmary of Edinburgh,9Antrim Area Hospital,10Torbay and South Devon NHS Foundation Trust,11University of Oxford, Oncology Clinical Trials Office,12Durham University, School of Medicine, Pharmacy and Health,13East and North Hertfordshire NHS Trust,14UHL,15Queen Alexandra Hospital,16Queen's University Belfast Faculty of Medicine Health and Life Sciences,17South Warwickshire NHS Foundation Trust,18Gloucester Royal, Dept of Surgery,19McMaster University Medical Centre,20University of Oxford

FOS/FOSB rearrangements; defining the human bone tumour, osteoblastoma

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Matthew Fittall1,Nischalan Pillay2,Anna-Christina Strobl3,Annelien Verfaillie1,Jonas Demeulemeester1,Maxime Tarabichi4,Matthew Young5,Agamemnon Grigoriadis6,Peter Van Loo4,Peter Campbell5,Adrienne Flanagan2,Sam Behjati7
1The Francis Crick Institute,2University College London,3Royal National Orthopaedic Hospital,4The Francis Crick Institure,5Wellcome Trust Sanger Institure,6King's College London,7Wellcome Trust Sanger Institute

Deeper investigation of the metabolic subgroup in colorectal cancer

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Tessa Sandberg1,Lennard Lee1,Roland Arnold1,Ian Tomlinson1
1university of birmingham

Predicting Drug Response in Cancer in Cancer Cell Lines using Deep Learning for precision treatments

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Jyothi Deva datta reddy1,Dr.ram Reddy2,Samyukta Reddy3
1Cancer moonshot @ www.cancermoonshot.in,2Care cancer center,3CancerMoonshot

Using Genetic Barcoding to Uncover the Evolutionary Dynamics of Drug Resistance Emergence in Colorectal Cancer.

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Freddie Whiting1,Richard Nichols2,Marc Williams1,Calum Gabutt3,Ann-Marie Baker1,Trevor Graham1
1Barts Cancer Institute,2Queen Mary University of London,3UCL

Effects of GLI3 knockdown in the maintenance of stemness in oral squamous cell carcinoma

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Maria Fernanda Rodrigues1,Lucyene Miguita2,Nathália Andrade2,Fabio Nunes2
1Nove de Julho University-Post Graduate Program in Biophotonics Applied to Health Science,2Oral Pathology, School of Dentistry, University of São Paulo

Combining p53-activating agents with HDAC inhibition results in suppression of FOXM1 and other genes associated with poor prognosis prostate cancer

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Gemma Gregg1,Fiammetta Falcone1,Andrea Lees1,Gerard Quinn1,Richard Kennedy2,Ian Mills1,Simon McDade1
1Queens University Belfast,2Almac Diagnostics

Glucagon-like petide-2 acts on colon cancer myofibroblasts to stimulate proliferation, migration and invasion of both myofibroblasts and cancer cells via the IGF pathway.

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Marianne Shawe-Taylor1
1Queen's Hospital Romford

Phenotypic Subtyping of Matched Primary Colonic Tumours and Liver Metastases

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Kathryn Pennel1,Arfon Powell2,Donald McMillan1,Paul Horgan1,Antonia Roseweir1,Joanne Edwards1
1University of Glasgow,2Cardif University

Chromosomal instability drives non-random chromosome mis-segregation

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Sarah McClelland1,Joseph Worrall1,Naoka Tamura1,Alice Mazzagatti1,Nadeem Shaikh1,Tineke van Lingen1,Bjorn Bakker2,Dinana Spierings2,Elina Vladimirou3,Floris Foijer2
1Barts Cancer Institute,2ERIBA,3UCL Cancer Institute

Clonal evolution of breast cancer treated with palbociclib and fulvestrant: a circulating tumour DNA analysis of the PALOMA-3 trial

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Ben O'Leary1,Ros Cutts1,Yuan Liu2,Sarah Hrebien1,Xin Huang2,Matthew Beaney1,Kerry Fenwick1,Fabrice Andre3,Sibylle Loibl4,Sherene Loi5,Isaac Garcia-Murillas1,Cynthia Huang Bartlett2,Massimo Cristofanilli6,Nicholas Turner7
1The Institute of Cancer Research,2Pfizer,3Institut Gustave Roussy, France,4German Breast Group,5University of Melbourne, Peter MacCallum Cancer Centre,6Robert H Lurie Comprehensive Cancer Centre, Feinberg School of Medicine,Chicago,7The Institute of Cancer Research and The Royal Marsden Hospital

Molecular mechanisms underlying phenotypic plasticity in malignant glioma

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Costanza Lo Cascio1,Ernesto Luna1,Rohit Khurana1,Roberto Fiorelli1,Shwetal Mehta1
1Barrow Neurological Institute

Characterising a novel signalling cascade involved in the development of breast cancer brain metastasis

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Chiara Galloni1,Teklu Egnuni1,Renu Gahlaut1,Michael Grant1,Valerie Speirs1,Mihaela Lorger1,Georgia Mavria1
1University of Leeds

The role of IKK-alpha in colorectal cancer

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Meera Patel1,Hannah Hood2,Jean Quinn3,Antonia Roseweir3,Arfon Powell4,Paul Horgan3,Donald McMcMillan3,Joanne Edwards1
1Institute of Cancer Sciences, University of Glasgow,2School of Medicine, University of Glasgow,3Academic Unit of Surgery, University of Glasgow,4School of Medicine, Cardiff University

Identifying Oncogenic Drivers of Poor Outcome in Triple Negative Breast Cancer

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Shannon Beattie1
1CCRCB

Maximising FLIM-FRET Biosensor Capabilities for Cancer Studies

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Kirsty Martin1
1CRUK Beatson Institute

The molecular mechanism behind PD-L1 upregulation upon 5-fluorouracil treatment in colorectal cancer cells

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Tamas Sessler1,Fiammetta Falcone2,Timothy Wright2,Peter Gallagher2,Daniel Longley3,Simon McDade2
1DRG/FGG QUB,2FGG QUB,3DRG QUB

Glycolysis supports EGFR-mutant Lung Adenocarcinoma Cell Survival by blocking Autophagy-mediated EGFR Degradation

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Wonjun Ji1,Jin Kyung Rho1,Jaekyoung Son1,Jae Cheol Lee1,Chang-Min Choi1
1Asan Medical Center

DNA replication stress generates radiation resistance in glioblastoma stem like cells

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Ross Carruthers1
1University of Glasgow

Defining novel mechanisms critical for colorectal tumourigenesis

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Patrizia Cammareri1,Caroline Billard2,Victoria Gudiño2,Kevin Myant2
1ECRC,2Cancer Research UK Edinburgh Centre

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models

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Antonio Garcia-Trinidad1,Steve Durant2,Lucy Riches1,Jacqueline Fok1,Tom Hunt1,Kurt Pike2,Joanne Wilson1,Aaron Smith1,Nicola Colclough1,Venkatesh Pilla Reddy2,Andrew Sykes1,Annika Janefeldt1,Peter Johnström1,Stephanie Ling1,Jonathan Orme1,Jonathan Stott1,Caroline Roberts1,Ian Barrett1,Gemma Jones1,Martine Roudier1,Andrew Pierce1,Kristoffer Valerie3,Martin Pass1
1Astrazeneca,2AstraZeneca,3Commonwealth University

Investigating the role of dysregulated RNA splicing in colorectal cancer initiation and progression

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Adam Hall1,Kevin Myant1
1Institute of Genetics and Molecular Medicine, The University of Edinburgh

The interaction of galectin-3 with TAM receptors in activating signalling pathways for human cancer cell survival and migration.

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Nour Al Kafri1,Sassan Hafizi1
1University of Portsmouth

Investigating the relationship between proteomic and transcriptomic expression of key immune markers in HGSOC and their clinical relevance for patients.

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Laura Webster1,Manuel Salto-Tellez1,Darragh McArt1,Charlie Gourley2,Richard Kennedy1,Stephanie Craig1,Robb Hollis2,Matthew Alderdice1
1CCRCB,2University of Edinburgh

Functional Role of Circular NFATC3 in Triple Negative Breast Cancer

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Fatima Al-Dasim1,Thasni Karedath1,Stephanie Aron Ramadan1,Nayra Al-Thani1,Joel Malek1
1Weill Cornell Medicine-Qatar