215 abstracts found.



Understanding the role of gamma-delta (γδ) T cells in pancreatic cancer.

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Mark Lawrence1,Saadia Karim2,Jennifer P. Morton2,Seth B. Coffelt2
1,2Cancer Research UK Beatson Institute

MIR1249 mediates chemoresistance in cholangiocarcinoma by controlling the growth of CD133+ sub-clones

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Pietro Carotenuto1,Vincenzo Cardinale2,Matteo Fassan3,Aldo Scarpa4,Andrea Lampis1,Luciano Cascione5,Somaieh Hedayat1,Domenico Alvaro2,Michele Ghidini6,Nicola Valeri1,Robert Te Poele1,Sofia Ventura1,Luke Boulter7,Rachel Guest7,Stuart Forbes7,Massimo Rugge3,Umberto Cillo3,Elizabeth Smyth8,David Cunningham8,Lorenza Rimassa9,Armando Santoro9,Massimo Roncalli9,Paul Clarke1,Paul Workman1,Rajesh Chopra1,Chiara Braconi1
1Institute of Cancer Research,2University Sapienza of Rome,3University of Padua,4University of Verona,5Institute of Oncology Research,6iInstitute of Cancer Research,7University of Edinburgh,8Royal Marsden Hospital,9Humanitas Cancer Center

Identification and targeting of metabolic vulnerabilities in leukaemic stem cells using integrated omic approach

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Vignir Helgason1,Zuzana Brabcova1,Kevin Rattigan1,Lisa Hopcroft1,Eyal Gottlieb2,Alexei Vazquez3
1University of Glasgow,24Technion Integrated Cancer Center,3Cancer Research UK, Beatson Institute

T Cells engineered to express the IL-13Rα2 specific CAR and a PD-L1 specific switch receptor show increased anti-tumor activity in the Glioblastoma tumor microenvironment

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Abel De Castro1,Abel De Castro1,Grant Wilson1,Megan Keys1,Jonathan Arroyo1
1Azusa Pacific University

Hypoxia PET/CT in Non Small Cell Lung Cancer cell lines

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Kirsten Laws1,Sergio Dall'angelo1,Lutz Schweiger1,Leslie Samuel2,Ian Fleming1
1University of Aberdeen,2NHS Grampian

C-terminal tensin-like (CTEN) ability to induce cell migration is independent of its interaction with β-catenin in colorectal cancer cell line

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Abdulaziz Alfahed1,Teresa Raposo1,Mohammad Ilyas1
1Molecular Pathology Group and Nottingham Molecular Pathology Node, School of Medicine, University of Nottingham

Role of E3 Ubiquitin Ligase FBXO31 in Ovarian Cancer Malignancy

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Sehbanul Islam1
1National Centre for Cell Science

Analysis of cell proliferation and tissue remodelling in colorectal cancer uncovers a KLF4 transcriptional activity signature associated with poor prognosis

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Silvia Halim1,Elke Markert2,Alexei Vazquez1
1Cancer Research UK Beatson Institute,2Institute of Cancer Sciences, University of Glasgow

Multiple myeloma increases autophagy in the bone marrow stromal cells which is regulated by NRF2 signalling

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Yu Sun1,Charlotte Hellmich1,Matthew Jefferson1,Thomas Wileman1,Kristian Bowles1,Stuart Rushworth1
1University of East Anglia

Investigating Aspirin and Ticagrelor for the prevention of tumour cell-induced platelet aggregation.

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Meera Chauhan1,David Adlam1,Anne Thomas1,Alison Goodall1,Joy Wright1
1University of Leicester

METASTASIS GENE DISCOVERY:- A WHOLE GENOME CRISPR KNOCKOUT SCREEN AND MURINE ENDOSCOPY IDENTIFIES FOXF1 AS A SUPPRESSOR OF COLORECTAL CANCER METASTASIS

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Lennard YW Lee1,Connor Woolley2,Ian Tomlinson2
1Institute of Cancer Sciences, Universityof Birmingham,2Institute of Cancer Sciences, University of Birmingham

The role of translational elongation loss in colorectal cancer

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Nikola Vlahov1,John Knight1,Owen Sansom1
1The Beatson Institute for Cancer Research

Strategic Bioassay guided fractionation – Isolation and characterization of novel, systematic, potent antiangiogenic molecules from seaweed associated actinomycetes

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Meenakshi Sundaram K1,Vincent S1,SUVRO Chatterjee2
1LOYOLA INSTITUTE OF FRONTIER ENERGY,2AUKBC, ANNA UNIVERSITY

Screen failures in Phase I trials – a single institution experience.

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Sreeja Aruketty1,Nadina Tinsley1,Joseph Cope1,Matthew Krebs1,Louise Carter1,Fiona Thistlethwaite1,Andrew Hughes1,Natalie Cook1
1Christie NHS Foundation Trust

Identifying IFITM1-dependent synthesized proteins in interferon gamma stimulated cells

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Maria Gomez Herranz1,Dr. Jakub Faktor2,Dr. Marta Nekulová2,Prof. Lenka Hernychova2,Prof. Borek Vojtesek2,Prof. Kathryn Ball3,Prof. Ted Hupp3
1University of Edinburgh, 1Institute of Genetics and Molecular Medicine,2Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute,3University of Edinburgh, Institute of Genetics and Molecular Medicine

CRISPR/Cas9 mediated PTEN knockout induces EMT through Akt/β-Catenin/Snail signaling in non-small cell lung carcinoma cells

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Perumal Elumalai1,Kim So Youn1,Yeun Jun Chung1
1The Catholic University of Korea

PAK2-c-MYC-PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect

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Amit Gupta1,Sanjeev Shukla2
1Indian Institute of Science Education and Research,2Indian Institute of Science Education and Research Bhopal

Wnt/beta-catenin synergises with FOXG1 to drive exit from quiescence in neural stem cells, including glioblastoma stem cells

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Faye Robertson1,Harry Bulstrode1,Maria-Angeles Marques Torrejon1,Eoghan O'Duibhir1,Steve Pollard1
1University of Edinburgh

Tackling the Tgf-beta paradox via engineered organoids

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Michela Raponi1,Rene Jackstadt2,Stuart Aitken1,Philip Dunne3,Owen Sansom2,Kevin Myant1
1University of Edinburgh,2University of Glasgow,3Queens's University Belfast

DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-ribose) glycohydrolase inhibitors.

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Nisha Pillay1,Anthony Tighe1,Nourdine Bah1,Louisa Nelson1,Samantha Littler1,Dominic James2,Kate Smith1,Allan Jordan1,Donald Olgilvie1,Stephen Taylor1
1Manchester Cancer Research Centre,2Drug Discovery Unit, CRUK Manchester Institute

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

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Holger Auner1,Katarzyna Parzych1,Hibah Al-Sadah1,Mark Robinson1,Gabriel Valbuena1,Lucy Penfold1,Desislava Kuzeva1,Sandra Loaiza1,Valentina Caputo1,David Johnson2,Martin Kaiser2,Anastasios Karadimitris1,Eric Lam1,Eric Chevet3,Niklas Feldhahn1,Hector Keun1,Holger Auner1
1Imperial College London,2Institute of Cancer Research,3INSERM Universite de Rennes

Adenosine polarises human macrophages towards an immunosuppressive phenotype via the A2A and A2B adenosine receptors

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Hester Franks1,Andrew Jackson1,Stephen Hill1,Tajkia Musarrat1,Aanchal Kaur1,Poulam Patel1
1University of Nottingham

Characterisation of CRISPR-induced RET gatekeeper cell line in a medullary thyroid carcinoma model

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Habiba Begum1,Mandy Watson1,Elizabeth Blaikley1,Graeme Walker1,Ian Waddell1,Donald Ogilvie1,Caroline Springer1
1Cancer Research UK Manchester Institute

Phenotypic changes induced by low concentration of glutamine in pancreatic cancer cells: Effects of a hypomethylating therapy

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Jose Neptuno Rodriguez-Lopez1,Maria Fernanda Montenegro1,Luis Sanchez-del-Campo1,Rebeca Gonzalez-Guerrero1,Juan Cabezas-Herrera2
1University of Murcia,2Instituto Murciano de Investigación Biosanitaria. University Hospital Virgen de la Arrixaca

High-content Profiling in Oesophageal Adenocarcinoma for Identification and Mechanistic Characterisation of Small Molecules to Inform Preclinical Development and Patient Stratification

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Rebecca Hughes1,Richard Elliot1,Ashraff Makda1,Robert O'Neill1,Ted Hupp1,Neil Carragher1
1University of Edinburgh

Tumour-infiltrating lymphocytes correlate with circulating lymphocytes and influence survival

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Rashmi Verma1,Eldo T Verghese2,Clive RD Carter2,Kieran Horgan2,Thomas A Hughes3
1University of Leeds,2Leeds Teaching Hospitals NHS Trust,3Leeds Institue of Biomedical & Clinical Sciences

Understanding the role of γδ T cells in colorectal cancer

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Toshiyasu Suzuki1,Rachel Ridgeway1,Rene Jackstadt1,Joshua Leach1,Natalie Roberts2,Anett Jandke2,Adrian Hayday2,Owen Sansom1,Seth Coffelt1
1Cancer Research UK Beatson Institute,2Francis Crick Institute

Long non-coding RNA LINC00973 is a putative biomarker of colon cancer relapse

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Nikolai Lisitsyn1,Olga Zinovieva1,Evgenia Grineva1,Maria Prokofjeva1,Dmitry Karpov1,Andrei Zheltukhin1,George Krasnov1,Anastasiya Snezhkina1,Anna Kudryavtseva1,Peter Chumakov1,Tamara Mashkova1,Vladimir Prassolov1
1Engelhardt Institute of Molecular Biology

ACE: A Workbench using Evolutionary Genetic Algorithms for analyzing association in TCGA Data

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Alan Gilmore1,Matthew Alderdice1,Kienan Savage1,Paul O'Reilly1,Aideen Roddy1,Philip Dunne1,Mark Lawler1,Simon McDade1,David Waugh1,Darragh McArt1
1Centre for Cancer Research and Cell Biology, Queen's University Belfast

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix

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Selena Burgess1,Manjeet Mukherjee1,Sarah Sabir1,Nimesh Joseph2,Cristina Gutierrez-Caballero3,Mark Richards1,Nicolas Huguenin-Dezot4,Jason Chin4,Eileen Kennedy5,Mark Pfuhl6,Stephen Royle3,Fanni Gergely2,Richard Bayliss1
1University of Leeds,2University of Cambridge,3University of Warwick,4MRC Laboratory of Molecular Biology,5University of Georgia,6Kings College, London

Identification of novel targetable resistance mechanisms and candidate clinical response biomarkers in drug-resistant ovarian cancer, following single agent and combination chemotherapy

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Aparajitha Vaidyanathan1,Probir Chakravarthy2,Susan E Bray3,K Wendy McMullen4,Michelle J Ferguson4,Gillian Smith1
1Division of Cellular Medicine, School of Medicine, University of Dundee,2Bioinformatics and Biostatistics Service, Cancer Research UK,3Tayside Biorepository, University of Dundee,4NHS Tayside, Dundee

The preliminary results from the 100,000 Genomes Project: the genomic landscape of colorectal cancer

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William Cross1,Giulio Caravagna2,Jacob Houseman1,Alona Sosinsky3,Nirupa Murugaesu3,Daniel Chubb2,Alexander Cornish2,Anna Frangou4,John Ambrose3,David Wedge4,Richard Houlston2,Andrea Sottoriva2,Trevor Graham1,Ian Tomlinson5
1Queen Mary University, Barts Cancer Institute,2The Institute of Cancer Research,3Genomics England,4The Big Data Institute University of Oxford,5Institute of Cancer and Genomic Sciences Birmingham University

Improving the representability of samples donated to a specialist breast cancer biobank using core needle biopsy

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Jenna Williams1,Andrew Hanby1,Valerie Speirs2
1University of Leeds,2University of Aberdeen

TBX2 interacts with Heterochromatin Protein 1 to recruit a novel repression complex to EGR1-responsive promoters and promote the proliferation of breast cancer cells

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Alexander McIntyre1,Nyree Crawford1,Anna McCormick1,Zenobia D'Costa1,Naomi Dickson1,Niamh Buckley1,Paul Mullan1
1QUB

Understanding why prostate cancer is multifocal

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Claudia Buhigas1,Colin Cooper1,David Wedge2,Daniel Brewer1
1University of East Anglia,2Oxford Big Data Institute

Regulation of IL-17-producing γδ T cells in breast cancer metastasis.

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Sarah C. Edwards1,Anna Kilbey2,Robert Wiesheu2,Erin R. Morris3,Liam Hayman2,Damiano Rami2,Seth B. Coffelt2
1Beatson CRUK,2Beatson CRUK. Institute of Cancer Sciences, University of Glasgow.,3Baker University, Baldwin City, Kansas

Nuclear morphometry features distinguish cell types and outcome groupings in lung cancer

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Katey Enfield1,Spencer Martin2,Erin Marshall2,Zhaolin Xu3,Martial Guillaud2,Calum MacAulay2,Wan Lam2
1British Columbia Cancer Research Centre,2BC Cancer,3Dalhousie University

Understanding the links between mutations in the BAF/PBAF chromatin-remodeling complexes and expression in Kidney ccRCC cancer

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Noora Al-Muftah1
1Qatar Foundation

BIOLOGICAL FACTORS IN PAIRED TUMOUR AND PLASMA SAMPLES: RELATIONSHIP TO COLORECTAL CANCER PATHOLOGY AND 15-YEAR SURVIVAL

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Liz Baker1,Norma Robinson2,Mohamed Tabaqchali2,David Leaper2
1North Tees and Hartlepool NHS Foundation Trust,2UNIVERSITY HOSPITAL OF NORTH TEES

Multi-parameter flow cytometry immune profiling of head and neck and salivary gland cancers.

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Rizwana Sharmin Rahman1,Gareth Howell1,Anupam Goenka1,Emma Connolly1,Christopher Jagger1,Guy Betts2,Jarrod Homer2,Tracy Hussell1,Robert Metcalf1
1University of Manchester,2Manchester University NHS Foundation Trust

A novel high-throughput multi-parametric drug screening method for 3D tumor spheroids using Celigo image cytometer

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Leo Chan1,Scott Cribbes1,Sarah Kessel1,Jean Qiu1,Suzanne Riches1
1Nexcelom Bioscience

Characterising mechanisms of acquired resistance in Triple Negative Breast Cancers (TNBCs)

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Charlotte McBrien1
1Queens University Belfast

MMP9 circulating levels and promoter polymorphism in risk prediction of breast cancer

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Farhad Mashayekhi1,Farbod Bahreini2
1University of Guilan, Rasht,2University of Guilan, Iran

Tumour suppressing and tumour promoting TGFß signalling in squamous cell cancers.

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Richard Taylor1,Aidan Rose1,Charlotte Proby1,Irene Leigh1,Gareth Inman1
1University of Dundee

Investigating the Interplay between Wilms’ Tumour 1 Protein and DNA Demethylation in Brain Tumours

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Ashley Ramsawhook1,Ashley Ramsawhook1
1University of Nottingham

Single cell copy number variation analysis (CNV) of circulating tumour cells (CTCs) in neuroendocrine tumour (NET) patients

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Alexa Childs1,Clare Vesely1,Francesca Rizzo1,Leah Ensell1,Helen Lowe1,Christina Thirlwell1,Christos Toumpanakis2,Martyn Caplin2,John Hartley1,Tim Meyer1
1UCL Cancer Institute,2Royal Free Hospital, London

Dual CRISPRi and CRISPRa screening reveals phenotypic switches in BRAF inhibition

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Abhay Joshi1,Jochen Hartner1
1Horizon Discovery

Counteracting breast cancer metastasis: Harnessing anti-tumour γδ T cells and targeting the RON-MSP axis

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Sarah-Jane Remak1,Kyla Foster1,Sandeep Dhayade1,Karen Blyth1,Seth Coffelt1
1The Beatson Institute

Multiple mutation detection from circulating tumour DNA can be a valid tool in endocrine resistance of estrogen-receptor positive breast cancer patients: Experience from the FAKTION trial.

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Magdalena Meissner1,Rachel Butler2,Robert Jones3
1Cardiff University,2Cardiff and Vale UHB - Medical Genetics,3Velindre Cancer Centre

Highly characterized patient derived breast cancer collection for preclinical efficacy studies

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Abhay Joshi1,Jochen Hartner1
1Horizon Discovery