237 abstracts found.



Modulation of RAB5A early endosome trafficking in response to KRas mediated macropinocytic fluxes in pancreatic cancer cells

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Christian Teske1,Christine Schweitzer1,Andrea Palamidessi2,Daniela Aust3,Giorgio Scita2,Jürgen Weitz1,Thilo Welsch1
1University Hospital Dresden, Dept. of Visceral, Thoracic and Vascular Surgery,2Fondazione Istituto FIRC di Oncologia Molecolare (IFOM),3University Hospital Dresden, Dept. of Pathology

Study of circulating DNA structures and origins

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Zahra Al Amir Dache1,Amaelle Otandault1,Corinne Prevostel1,Alain Thierry1
1Institut de recherche en cancérologie de montpellier

MUC1 Regulates TGF-Β Function in Pancreatic Cancer

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Priyanka Grover1,Mahboubeh Yazdanifar1,Mohammad Ahmad1,Ru Zhou1,Angat Puri1,Kajal Grover2,Xinghua Shi1,Pinku Mukherjee1
1University of North Carolina at Charlotte,2University of North Carolina at Chapel Hill

An Effective Pipeline for Whole Genome Sequencing for Research in a Tertiary Cancer Centre

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George Morrissey1,Alison Berner2,Tracy Odigie3,Alice Rendall3,Keith Rogerson3,Rahul Kurup3,Glen Brice3,Helen Hanson3,John Short3,Katie Snape3,Ruth Pettengel3,Nirupa Murugaesu2
1,2Genomics England,3St George's University Hospital NHS Trust

Oncogenic KRAS rewires translation in colorectal cancer allowing targeting via the p38/MNK/eIF4E pathway

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John Knight1,William Faller2,David Gay1,Nikola Vlahov1,Rachel Ridgway1,Christopher Proud3,Angel Nebreda4,Martin Bushell1,Anne Willis5,Owen Sansom1
1CRUK Beatson Institute,2NKI,3SAHMRI Adelaide,4IRB Barcelona,5MRC Toxicology Unit

Endoglin expression on cancer-associated fibroblasts regulates invasion and stimulates colorectal cancer metastasis

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Madelon Paauwe1,Mark Schoonderwoerd2,Roxan Helderman2,Tom Harryvan2,Arwin Groenewoud3,Gabi van Pelt2,Rosalie Bor2,Danielle Hemmer2,Henri Versteeg2,Ewa Snaar-Jagalska3,Charles Theuer4,James Hardwick2,Cornelis Sier2,Peter ten Dijke2,Lukas Hawinkels2
1Beatson Institute for Cancer Research,2Leiden University Medical Center,3Institute of Biology, Leiden University,4Tracon Pharmaceuticals

Amino acid transporter SLC7A5 is required for growth of Kras-mutant colorectal cancer in vivo

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Arafath Najumudeen1,Fatih Ceteci1,Owen Sansom1
1Beatson Institute for Cancer Research

Bowel cancer genetics: investigating chromosomal instability by CRISPR knockout panels

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Fadipe Adetokunbo1,Lennard YW Lee2
1Merton College, Oxford,2Institute of Cancer Sciences, University of Birmingham

Analysis of proteomic changes in human breast carcinoma MDA-MB-231 cells induced by tributyltin isothiocyanate, the biologically active ligand of nuclear retinoid X receptors

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Julius Brtko1,Dana Strouhalova2,Lucia Toporova1,Dana Macejova1,Pavel Bobal3,Jan Otevrel3,Janette Bobalova2
1Institute of Experimental Endocrinology, BMC, Slovak Academy of Sciences, Bratislava,2Institute of Analytical Chemistry of the CAS, v. v. i., Brno,3Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Brno

Epigenetic inactivation of the epithelial splicing factor ESRP2 in Wilms’ tumour

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Danny Legge1,Whei Moriarty1,Sebastian Oltean2,Karim Malik1,Keith Brown1
1University of Bristol,2University of Exeter

Clinical implications of context specificity of dynamic signalling patterns in KRAS mutant cancers

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Adam Stewart1
1Institute of Cancer Research

Dysfunctional mitochondria are exported from myeloma cells to the bone marrow microenvironment

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Yu Sun1,Yu Sun1,Christopher Marlein1,Charlotte Hellmich1,Kristian Bowles1,Stuart Rushworth1
1University of East Anglia

Identification of therapeutic targets for Head and Neck Squamous Cell Carcinoma (HNSCC)

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Ahmad Malik1
1University of Toronto

eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival.

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Hannah Bolland1,Alan McIntyre1,Abdol Shams-Nateri1,Cleo Bishop2,Andrew Silver2
1University of Nottingham,2Blizzard Institute Barts and the London School of Medicine and Dentistry

Targeting RSK4 prevents both chemoresistance and metastasis in lung cancer

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Stelios Chrysostomou1,Rajat Roy1,Filippo Prischi2,Katie Chapman3,Uwais Mufti4,Robert Peach1,Francesco Mauri1,Joel Abrahams1,Eric Aboagye1,Maruf Ali1,Michael Seckl1,Olivier Pardo1
1Imperial College London,2University of Essex,3Assay Biology, Domainex Ltd,4Department of Urology, Leeds Teaching Hospitals NHS Trust

Precision therapy in the p53 pathway

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Chit Fang Cheok1,Luis Coronel2,Ramesh Kumar3,Bhagi Somalanka3,Raju Anandh1,Obed Aning4,Ping Yin Hor5,An Omer6,Yingswan Ho7,Chen Shuwen7,Shi Ya Mak7,Henry Yang8,Mani LAKSHMANAN4,Hideki Itoh9,Soo Yong Tan10,Timothy Lim11,Adele Wong11,Sung Hock Chew11,The Hung Huynh12,Boon Cher Goh13,Vinay Tergoankar4,Chin Yan Lim9
1Institute of Molecular and Cell Biology (IMCB), A*STAR,2p53Laboratory, A*STAR,3IFOM-p53Lab JRL,4Institute of Molecular and Cell Biology (IMCB),5IFOM-p53Lab, A*STAR,6Cancer Science Institut, NUS,7Bioprocessing Technology Institute, A*STAR,8Cancer Science Institute, NUS,9Institute of Medical Biology, A*STAR,10Department of Pathology, NUS,11KK Women’s and Children’s Hospital,12National Cancer Center Singapore,13National University Cancer Institute

A Living Biobank Of Ovarian Cancer Ex Vivo Models Reveals Profound Mitotic Heterogeneity

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Stephen Taylor1
1University of Manchester

Fibroblast growth factor signalling influences platinum chemoresistance in ovarian cancer by altering both epithelial-to-mesenchymal transition and the DNA damage response

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Hugh Nicholson1,Francesco Rao2,Gillian Smith1
1University of Dundee,2DC Biosciences Ltd.

Ciz1 accumulation is regulated by opposing cyclin dependent kinase (CDK) and ubiquitin-proteasome system (UPS) activities

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Tekle Pauzaite1
1Lancaster University

Genomic analysis of Malaysian breast cancers unravel molecular differences from Caucasian breast cancers

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Muhammad Mamduh Ahmad Zabidi1,Jia Wern Pan1,Patsy Pei Sze Ng1,Mei Yee Meng1,Stephen-John Sammut2,Oscar Rueda2,Carlos Caldas2,Suet-Feung Chin2,Soo-Hwang Teo1
1Cancer Research Malaysia,2Cancer Research UK Cambridge Institute

An Immunoscore for Ovarian Cancer: Preliminary Evidence for Predicting the Ability to Expand Tumour-Infiltrating Lymphocytes from Surgical Biopsies

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James Platt1,Gemma Owens1,Richard Edmondson2
1The University of Manchester,2The University of MAnchester

Defining the role of FOSL2 in molecular adaptation to hypoxia in colorectal cancer

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Eric VANCAUWENBERGHE1,Hannah Bolland1,Christopher Carroll1,Leonardo Da Motta1,Victoria Wright2,Nadine Holmes2,Francesca Buffa3,Anna Grabowska4,Adrian Harris5,Alan McIntyre6
1Hypoxia and Tumour Microenvironment Group, Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,2Deep Seq, School of Life Sciences, University of Nottingham,3Computational Biology and Integrative Genomics, Department of Oncology, University of Oxford,4Cancer Biology, Division of Cancer and Stem Cells, University of Nottingham,5Molecular Oncology Laboratories, Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford,6University of Nottingham

Understanding the role of gamma-delta (γδ) T cells in pancreatic cancer.

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Mark Lawrence1,Saadia Karim2,Jennifer P. Morton2,Seth B. Coffelt2
1,2Cancer Research UK Beatson Institute

MIR1249 mediates chemoresistance in cholangiocarcinoma by controlling the growth of CD133+ sub-clones

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Pietro Carotenuto1,Vincenzo Cardinale2,Matteo Fassan3,Aldo Scarpa4,Andrea Lampis1,Luciano Cascione5,Somaieh Hedayat1,Domenico Alvaro2,Michele Ghidini6,Nicola Valeri1,Robert Te Poele1,Sofia Ventura1,Luke Boulter7,Rachel Guest7,Stuart Forbes7,Massimo Rugge3,Umberto Cillo3,Elizabeth Smyth8,David Cunningham8,Lorenza Rimassa9,Armando Santoro9,Massimo Roncalli9,Paul Clarke1,Paul Workman1,Rajesh Chopra1,Chiara Braconi1
1Institute of Cancer Research,2University Sapienza of Rome,3University of Padua,4University of Verona,5Institute of Oncology Research,6iInstitute of Cancer Research,7University of Edinburgh,8Royal Marsden Hospital,9Humanitas Cancer Center

Identification and targeting of metabolic vulnerabilities in leukaemic stem cells using integrated omic approach

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Vignir Helgason1,Zuzana Brabcova1,Kevin Rattigan1,Lisa Hopcroft1,Eyal Gottlieb2,Alexei Vazquez3
1University of Glasgow,24Technion Integrated Cancer Center,3Cancer Research UK, Beatson Institute

T Cells engineered to express the IL-13Rα2 specific CAR and a PD-L1 specific switch receptor show increased anti-tumor activity in the Glioblastoma tumor microenvironment

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Abel De Castro1,Abel De Castro1,Grant Wilson1,Megan Keys1,Jonathan Arroyo1
1Azusa Pacific University

Hypoxia PET/CT in Non Small Cell Lung Cancer cell lines

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Kirsten Laws1,Sergio Dall'angelo1,Lutz Schweiger1,Leslie Samuel2,Ian Fleming1
1University of Aberdeen,2NHS Grampian

C-terminal tensin-like (CTEN) ability to induce cell migration is independent of its interaction with β-catenin in colorectal cancer cell line

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Abdulaziz Alfahed1,Teresa Raposo1,Mohammad Ilyas1
1Molecular Pathology Group and Nottingham Molecular Pathology Node, School of Medicine, University of Nottingham

Role of E3 Ubiquitin Ligase FBXO31 in Ovarian Cancer Malignancy

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Sehbanul Islam1
1National Centre for Cell Science

Analysis of cell proliferation and tissue remodelling in colorectal cancer uncovers a KLF4 transcriptional activity signature associated with poor prognosis

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Silvia Halim1,Elke Markert2,Alexei Vazquez1
1Cancer Research UK Beatson Institute,2Institute of Cancer Sciences, University of Glasgow

Multiple myeloma increases autophagy in the bone marrow stromal cells which is regulated by NRF2 signalling

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Yu Sun1,Charlotte Hellmich1,Matthew Jefferson1,Thomas Wileman1,Kristian Bowles1,Stuart Rushworth1
1University of East Anglia

Investigating Aspirin and Ticagrelor for the prevention of tumour cell-induced platelet aggregation.

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Meera Chauhan1,David Adlam1,Anne Thomas1,Alison Goodall1,Joy Wright1
1University of Leicester

METASTASIS GENE DISCOVERY:- A WHOLE GENOME CRISPR KNOCKOUT SCREEN AND MURINE ENDOSCOPY IDENTIFIES FOXF1 AS A SUPPRESSOR OF COLORECTAL CANCER METASTASIS

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Lennard YW Lee1,Connor Woolley2,Ian Tomlinson2
1Institute of Cancer Sciences, Universityof Birmingham,2Institute of Cancer Sciences, University of Birmingham

The role of translational elongation loss in colorectal cancer

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Nikola Vlahov1,John Knight1,Owen Sansom1
1The Beatson Institute for Cancer Research

Strategic Bioassay guided fractionation – Isolation and characterization of novel, systematic, potent antiangiogenic molecules from seaweed associated actinomycetes

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Meenakshi Sundaram K1,Vincent S1,SUVRO Chatterjee2
1LOYOLA INSTITUTE OF FRONTIER ENERGY,2AUKBC, ANNA UNIVERSITY

Screen failures in Phase I trials – a single institution experience.

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Sreeja Aruketty1,Nadina Tinsley1,Joseph Cope1,Matthew Krebs1,Louise Carter1,Fiona Thistlethwaite1,Andrew Hughes1,Natalie Cook1
1Christie NHS Foundation Trust

Identifying IFITM1-dependent synthesized proteins in interferon gamma stimulated cells

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Maria Gomez Herranz1,Dr. Jakub Faktor2,Dr. Marta Nekulová2,Prof. Lenka Hernychova2,Prof. Borek Vojtesek2,Prof. Kathryn Ball3,Prof. Ted Hupp3
1University of Edinburgh, 1Institute of Genetics and Molecular Medicine,2Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute,3University of Edinburgh, Institute of Genetics and Molecular Medicine

CRISPR/Cas9 mediated PTEN knockout induces EMT through Akt/β-Catenin/Snail signaling in non-small cell lung carcinoma cells

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Perumal Elumalai1,Kim So Youn1,Yeun Jun Chung1
1The Catholic University of Korea

PAK2-c-MYC-PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect

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Amit Gupta1,Sanjeev Shukla2
1Indian Institute of Science Education and Research,2Indian Institute of Science Education and Research Bhopal

Wnt/beta-catenin synergises with FOXG1 to drive exit from quiescence in neural stem cells, including glioblastoma stem cells

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Faye Robertson1,Harry Bulstrode1,Maria-Angeles Marques Torrejon1,Eoghan O'Duibhir1,Steve Pollard1
1University of Edinburgh

Tackling the Tgf-beta paradox via engineered organoids

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Michela Raponi1,Rene Jackstadt2,Stuart Aitken1,Philip Dunne3,Owen Sansom2,Kevin Myant1
1University of Edinburgh,2University of Glasgow,3Queens's University Belfast

DNA replication vulnerabilities render ovarian cancer cells sensitive to poly(ADP-ribose) glycohydrolase inhibitors.

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Nisha Pillay1,Anthony Tighe1,Nourdine Bah1,Louisa Nelson1,Samantha Littler1,Dominic James2,Kate Smith1,Allan Jordan1,Donald Olgilvie1,Stephen Taylor1
1Manchester Cancer Research Centre,2Drug Discovery Unit, CRUK Manchester Institute

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation

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Holger Auner1,Katarzyna Parzych1,Hibah Al-Sadah1,Mark Robinson1,Gabriel Valbuena1,Lucy Penfold1,Desislava Kuzeva1,Sandra Loaiza1,Valentina Caputo1,David Johnson2,Martin Kaiser2,Anastasios Karadimitris1,Eric Lam1,Eric Chevet3,Niklas Feldhahn1,Hector Keun1,Holger Auner1
1Imperial College London,2Institute of Cancer Research,3INSERM Universite de Rennes

Adenosine polarises human macrophages towards an immunosuppressive phenotype via the A2A and A2B adenosine receptors

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Hester Franks1,Andrew Jackson1,Stephen Hill1,Tajkia Musarrat1,Aanchal Kaur1,Poulam Patel1
1University of Nottingham

Characterisation of CRISPR-induced RET gatekeeper cell line in a medullary thyroid carcinoma model

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Habiba Begum1,Mandy Watson1,Elizabeth Blaikley1,Graeme Walker1,Ian Waddell1,Donald Ogilvie1,Caroline Springer1
1Cancer Research UK Manchester Institute

Phenotypic changes induced by low concentration of glutamine in pancreatic cancer cells: Effects of a hypomethylating therapy

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Jose Neptuno Rodriguez-Lopez1,Maria Fernanda Montenegro1,Luis Sanchez-del-Campo1,Rebeca Gonzalez-Guerrero1,Juan Cabezas-Herrera2
1University of Murcia,2Instituto Murciano de Investigación Biosanitaria. University Hospital Virgen de la Arrixaca

High-content Profiling in Oesophageal Adenocarcinoma for Identification and Mechanistic Characterisation of Small Molecules to Inform Preclinical Development and Patient Stratification

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Rebecca Hughes1,Richard Elliot1,Ashraff Makda1,Robert O'Neill1,Ted Hupp1,Neil Carragher1
1University of Edinburgh

Tumour-infiltrating lymphocytes correlate with circulating lymphocytes and influence survival

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Rashmi Verma1,Eldo T Verghese2,Clive RD Carter2,Kieran Horgan2,Thomas A Hughes3
1University of Leeds,2Leeds Teaching Hospitals NHS Trust,3Leeds Institue of Biomedical & Clinical Sciences

Understanding the role of γδ T cells in colorectal cancer

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Toshiyasu Suzuki1,Rachel Ridgeway1,Rene Jackstadt1,Joshua Leach1,Natalie Roberts2,Anett Jandke2,Adrian Hayday2,Owen Sansom1,Seth Coffelt1
1Cancer Research UK Beatson Institute,2Francis Crick Institute

Long non-coding RNA LINC00973 is a putative biomarker of colon cancer relapse

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Nikolai Lisitsyn1,Olga Zinovieva1,Evgenia Grineva1,Maria Prokofjeva1,Dmitry Karpov1,Andrei Zheltukhin1,George Krasnov1,Anastasiya Snezhkina1,Anna Kudryavtseva1,Peter Chumakov1,Tamara Mashkova1,Vladimir Prassolov1
1Engelhardt Institute of Molecular Biology