772 abstracts found.



Evaluating the utility of hepatoma arterial-embolization prognostic (HAP) score in clinical practice to provide prognosis of hepatocellular carcinoma (HCC) irrespective of treatment modalities

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Nor Farzana Abdul Aziz1,Andrew Yeoman2,Marek Czajkowski2
1Cardiff University School of Medicine,2Royal Gwent Hospital, Newport

Three-Year Efficacy and Safety Update From the Phase III CheckMate 025 Study of Nivolumab Versus Everolimus in Patients With Advanced Renal Cell Carcinoma (aRCC)

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Padmanee Sharma1,Scott S Tykodi2,Bernard Escudier3,Michael Carducci4,Stephane Oudard5,Hans J. Hammers4,Saby George6,Daniel Castellano7,Ajjai S. Alva8,Martin E Richardet9,Christine Chevreau10,Elizabeth R. Plimack11,Sandhya Srinivas12,Giuseppe Procopio13,Jeffrey A. Sosman14,David F. McDermott15,Toni K. Choueiri16,Elmer Berghorn17,Lingfeng Yang17,Robert J. Motzer18,John Wagstaff19
1MD Anderson Cancer Center,2University of Washington and Fred Hutchinson Cancer Research Center,3Gustave Roussy,4Johns Hopkins Sidney Kimmel Comprehensive Cancer Center,5Hôpital Européen Georges Pompidou,6Roswell Park Cancer Institute,7Hospital Universitario,8University of Michigan,9Instituto Oncologico de Cordoba,10IUCT-O Institut Claudius Regaud,11Fox Chase Cancer Center,12Stanford Cancer Institute,13Fondazione Istituto Nazionale,14Vanderbilt University Medical Center,15Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center,16Dana-Farber Cancer Institute/Brigham and Women’s Hospital,17Bristol-Myers Squibb,18Memorial Sloan Kettering Cancer Center,19Swansea University

Primary endocrine therapy in elderly women with hormone sensitive breast cancer: disease response and clinical benefit outcomes

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Walid Sasi1,Petros Christopoulos1,Mihai Mancas1,Claire Murphy1
1Airedale General Hospital

Allowing GPs to Book 2-week Wait CRC Investigations Directly-Will we Open the Floodgates?

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Deji Odofin1,Anne Pullyblank2,Eric Loveday2,Anne Lyons2
1Walsall Healthcare NHS Trust,2North Bristol NHS Trust

Safety of Nivolumab in Patients With Clear Cell (CC) or Non-Clear Cell (NCC) Renal Cell Carcinoma (RCC): Results From the Phase IIIb/IV CheckMate 374 Study

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Joshua McFarlane1,Mark Olsen2,Ana Molina3,Todd M. Bauer4,Scott Tykodi5,Bradley Somer6,Mayer Fishman7,James Reeves8,Vijay Gunuganti9,Ray Page10,Sunil Babu11,Saby George12,Peter Van Veldhuizen13,Joshua Zhang14,Huanyu Zhao14,Nicholas Vogelzang15,John Wagstaff16
1Virginia Cancer Institute,2Tulsa Cancer Institute,3Weill Cornell Medical College,4Sarah Cannon Research Institute / Tennessee Oncology, PLLC,5University of Washington and Fred Hutchinson Cancer Research Center,6The West Clinic,7Moffitt Cancer Center,8Florida Cancer Specialists – South,9Cancer Care Centers of South Texas,10The Center for Cancer and Blood Disorders,11Fort Wayne Medical Oncology and Hematology,12Roswell Park Institute,13HCA Midwest Division,14Bristol-Myers Squibb,15Comprehensive Cancer Centers of Nevada,16Swansea University

New model for estimating glomerular filtration rate in patients with cancer results improves accuracy of carboplatin chemotherapy dosing

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Edward Williams1,Tobias Janowiz1,Andrea Marshall2,Nicola Ainsworth3,Peter Thomas4,Stephen Sammut1,Scott Shepherd5,Jeff White5,Patrick Mark5,Andy Lynch1,Duncan Joderell1,Simon Tavaré1,Helena Earl6
1Cancer Research UK Cambridge Institute,2Warwick Medical School,3Queen Elizabeth Hospital, King's Lynn,4University of Cambridge,5Beatson West of Scotland Cancer Centre,6Department of Oncology, University of Cambridge

Ultrasound-responsive lactic acid based agents for the delivery of targeted radiotherapy to solid tumours

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Irini Skaripa-Koukelli1,Ole Tietz1,Christophoros Mannaris2,Jason Brown3,Joshua Owen2,Robert Carlisle2,Katherine Vallis1
1CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology,2Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford,3Department of Physics, University of Oxford

Evaluation of single cell co-expression profiles of immune checkpoint therapeutic targets in the tumor microenvironment of Non-small Cell Lung Cancer

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Bradley Spencer-Dene1,Faraia Shah1,Na Li1,Jeff Kim1,Xiao-Jun Ma1,Emily Park1
1Advanced Cell Diagnostics

c-MYC – a novel regulator of mitotic cell fate which influences paclitaxel chemosensitivity in epithelial ovarian cancer?

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Sarah Hawco1,Lindsey Allan1,Aparajitha Vaidyanathan1,Michelle Ferguson2,Russell Petty1,Gillian Smith1,Paul Clarke1
1University of Dundee,2NHS Tayside

Mutation burden and other molecular markers of prognosis in the QUASAR2 clinical trial of colorectal cancer treated with curative intent

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Enric Domingo1,Carme Camps1,Pamela Kaisaki1,Marie Parsons2,Dmitri Mouradov2,Melissa Pentony1,Seiko Makino1,Michelle Palmieri3,Robyn Ward4,Nicholas Hawkins4,Peter Gibbs5,Hanne Askautrud6,Dahmane Oukrif7,Haitao Wang1,Joe Wood8,Elaine Johnstone1,Claire Palles1,David Church1,Marco Novelli7,Havard Danielsen6,Jon Sherlock8,David Kerr1,Rachel Kerr1,Oliver Sieber2,Jenny Taylor1,Ian Tomlinson1
1University of Oxford,2The Walter and Eliza Hall Institute of Medial Research,3The Walter and Eliza Hall Institute of Medical Research,4University of Queensland,5Royal Melbourne Hospital,6Oslo University Hospital,7University College London,8Thermo Fisher Scientific

Absorbed dose from ⁹⁰Y selective internal radiotherapy (SIRT) is correlated with individual lesion response in colorectal cancer patients.

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Elliot Abbott1,Nadia Falzone1,Helen Winter1,Tessa Greenhalgh1,Christiana Kartsonaki1,Alison Craig2,Ana Denis-Bacelar3,Glenn Flux2,Ricky Sharma4,Katherine Vallis1
1University of Oxford,2Institute of Cancer Research,3National Physical Laboratory,4University College London

Unravelling the role of novel uncharacterised long non-coding RNAs in the control of cell fate

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Katerina Bountali1,Mirna Mourtada-Maarabouni1
1Keele University

Use of NGS for stratification of patients with advanced NSCLC within the NHS using FFPE-extracted DNA from diagnostic biopsies

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Sumi Subramaniam1
1Cancer Research UK

Predictors of Lymph Node Count in Left-Sided Colon and Rectal Cancer Resections

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Nikhil Lal1,Nikhil Lal1,Andrea Sheel2,Fran McNicol2,Ufuk Gur2,Richard Heath2,Paul Rooney2
1University of Liverpool,2The Royal Liverpool University Hopsital

NON-EPITHELIAL PRIMARY BREAST NEOPLASMS: THE PREVALENCE AND MANAGEMENT OF A RARE CONDITION IN A SINGLE INSTITUTION OVER A 23 YEAR PERIOD

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Jack Nolan1,Liam Devane2,Chwanrow Baban2,Jane Rothwell2,Denis Evoy2,James Geraghty2,Anne O'Doherty2,Cecily Quinn2,Clare D'arcy2,Enda McDermott2,Ruth Prichard2
1St. Vincent's University Hospital Dublin,2St. Vincent's University Hospital

Deregulation of Long Noncoding RNA HOTTIP/HOXA13 expression associates with poor prognosis in cervical squamous cell carcinomas

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Sweta Sharma Saha1,Sharmila Sengupta2,Rahul Roy Chowdhury2,Nidhu Ranjan Mondal2,Sudipta Roy3
1Tata Medical Center,2Saroj Gupta Cancer Centre and Research Institute,3Sri Aurobindo Seva Kendra

AroCell TK 210 ELISA may complement pro PSA and the prostate health index in differentiating non-cancerous from cancerous conditions in prostate disease

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Kiran Kumar Jagalamudi1,Staffan Eriksson2,Mojca Zupan3,Kristina Kumer4,Teja Fabjan4,Goran Hlebič5,Tomaž Smrkolj5,Joško Osredkar4
1AroCell AB. www.arocell.com,2Swedish Agricultural University,3Blood Transfusion Unit, Ljubljana,4Institute of Clinical Biochemistry, Ljubljana,5University Medical Centre, Ljubljana

Preliminary results from a phase I dose-escalation study of the ATR inhibitor AZD6738 as monotherapy and in combination with palliative radiotherapy

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Magnus Dillon1,Dale Smith2,Kabir Mohammed2,Lyndall McLellan3,Simon Smith4,Emma Dean4,James Spicer5,Martin Forster6,Kevin Harrington1
1The Institute of Cancer Research,2The Royal Marsden NHS Foundation Trust,3Cancer Research UK,4AstraZeneca,5,6University College London Cancer Institute

Glutamine-Proline regulatory axis is associated with MYC expression in Luminal B breast cancer

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Andy Green1,Madeleine L. Craze1,Hayley Cheung1,Natasha Jewa1,Nuno D.M. Coimbra2,Daniele Soria3,Rokaya El-Ansari1,Mohammed A. Aleskandarany1,Kiu Wai Cheng1,Maria Diez-Rodriguez1,Christopher C. Nolan1,Ian O. Ellis4,Emad A. Rakha4
1University of Nottingham,2Istituto Portugues do Oncologia do Porta FG,3University of Westminster,4Nottingham University Hospitals NHS Trust

Research Database of Sequential Mammography Screening events: a resource for AI in breast cancer

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Mishal Patel1,Mark HAlling-Brown1
1Royal Surrey County Hospital

Multi-omic profiling and radiotherapy response in rectal cancer biopsies of COPERNICUS trial: results from SCORT (Stratification in COloRecTal cancer)

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Enric Domingo1,Andrew Blake1,Susan Richman2,Peter Stewart3,Alessandro Barberis1,Syed Haider1,Wei-Chen Cheng1,Philip Dunne3,Francesca Buffa1,Simon Gollins4,Tim Maughan1
1University of Oxford,2Leeds Institute of Cancer and Pathology,3Queens University,4North Wales Cancer Treatment Centre

MMP9, TIMP1, TIMP2 concentration in the serum of patients with meningioma

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Farhad Mashayekhi1,Sohail Mashayekhi2,Alia Saberi2
1University of Guilan, Rasht,2Neuroscience Research Center, Poursina Hospital, Guilan University of Medical Sciences, Rasht

Infrared imaging of oral squamous cell carcinoma can distinguish carcinoma from other cell types

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Janet Risk1,Barnaby Ellis1,John Chadwick1,James Ingham1,Richard Shaw2,Peter Weightman1
1University of Liverpool,2University of Liverpool & Aintree University Hospital NHS Trust

Symptom appraisal of potential lung cancer symptoms in people with Chronic Obstructive Pulmonary Disease

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Katie Robb1,Yvonne Cunninghamm1,Una Macleod2,Sara Macdonald1,Jo Waller3,Stephen Harrow4,Sally Wyke1,Katriina Whitaker5
1University of Glasgow,2Hull Medical School,3University College London,4NHS Greater Glasgow and Clyde,5University of Surrey

Does External Beam Radiation Boost to Pelvic Lymph Nodes Reduce Recurrence Rate in Patients with Locally Advanced Cervical Cancer?

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Caryn Wujanto1,Liang Shen2,David SP Tan1,Yiat Horng Leong3,Johann Tang3,Vicky Koh1
1National University Hospital, Singapore,2National University Singapore,3National University Hospital, SIngapore

From intracellular antibody fragments to small molecule inhibitors of mutant KRAS

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Camilo Quevedo1
1University of Oxford

Risk of second primary smoking-related cancers following lung cancer diagnosis

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Matthew Barclay1,Georgios Lyratzopoulos2,Fiona Walter1,Robert Rintoul3
1University of Cambridge,2University College London,3Papworth Hospital NHS Foundation Trust

R-spondin gain-of-function in colorectal cancer – a comparison between mature tumours and precursor polyps

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Sam Kleeman1,Roland Arnold1,on behalf of S-CORT Consortium2,Tim Maughan3,Simon Leedham1
1Wellcome Trust Centre for Human Genetics,2S-CORT Consortium,3CRUK/MRC Oxford Institute for Radiation Oncology

Hypoxia-activated prodrugs to deliver targeted radiosensitisation to hypoxic oesophageal tumours

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Ishna Mistry1,Ewen DD Calder2,Stuart J Conway2,Ester M Hammond1
1Oxford Institute for Radiation Oncology,2Chemistry Research Laboratory, University of Oxford

A novel NGS library preparation method for detection of mutations and gene-fusions in circulating cell-free DNA and RNA

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Guoliang Fu1,Sarah Scaife1,Winnie Wu2
1Genefirst ltd,2genefirst ltd

Branched chain amino acids regulate the sensitivity of breast and ovarian cancer cells to paclitaxel

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Alan Richardson1,Mohammed Abed1,Suad Ibrahim2
1Keele University,2keele university

Modern Cancer Analytics: a natural language application to a complex biological landscape

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Jessica Black1,Paul O'Reilly2,Manuel Salto-Tellez2,Darragh McArt2
1Bioinformatics and Integromics Laboratory, CCRCB,2CCRCB, Queen's University Belfast

Breast cancer liver metastases: systematic review and time to event metanalysis with comparison between available treatments

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Daniela Votano1,Zaed Hamady1,Hassan Malik2
1Southampton General Hospital,2University Hospital Aintree NHS Foundation Trust

Fulvestrant +/- Vandetanib in advanced aromatase inhibitor resistant breast cancer

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Joanna Smith1,Zoe Hudson2,Tracie-Ann Madden1,Angela Casbard1,Laura Butlin1,Terri Kitson1,Mark Beresford3,Peter Barrett-Lee4,Sacha Howell5,David Cameron6,Julia Gee2,Jacinta Abraham4,Kay Wilson4,Bethan Tranter4,Gareth Griffiths7,Lesley Radley8,Robert Jones4
1Centre for Trial Research, Cardiff University,2Cardiff University,3Royal United Hospital Bath,4Velindre Cancer Centre,5The University of Manchester,6The University of Edinburgh,7University of Southampton Clinical Trials Unit,8c/o Centre for Trial Research, Cardiff University

COPELIA: A Randomised Phase II Trial of Cediranib in Combination with Paclitaxel or Olaparib Versus Weekly Paclitaxel Chemotherapy as Second-Line Therapy for Advanced/Metastatic Endometrial Cancer

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Jennifer Swettenham1,Gordon Jayson2,Robert Morgan2,Dilly Goonetilleke3,Richard Edmondson3,Ann White4,Angela Casbard1,Tracie-Ann Madden1,Nisa Khan2,Charlotte Wilhelm-Benartzi1,Catherine Rogers2,Rebecca Kristeleit5,Andrew Clamp2
1Cardiff University,2The Christie NHS Foundation Trust,3University of Manchester,4,5University College London

Development of animal model to reduce anti-angiogenesis resistance in Glioblastoma

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Sreynet Srun1
1graduate school of cancer science and policy, national cancer center, south korea

IMvigor211: A global, open-label, phase III randomised study examining atezolizumab vs chemotherapy for platinum-treated advanced urothelial carcinoma

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Syed Hussain1,Thomas Powles2,Yohann Loriot3,Ignacio Durán4,Alain Ravaud5,Margitta M. Retz6,Nicholas J. Vogelzang7,Sanjeev Mariathasan8,Na Cui8,Christina L. Derleth8,Michiel S. van der Heijden9
1,2Barts Cancer Institute ECMC, Barts Health and the Royal Free NHS Trust, Queen Mary University of London,3Département de Médecine Oncologique, Université Paris-Saclay and Gustave Roussy,4Department of Medical Oncology, Hospital Universitario Virgen del Rocío and Institute of Biomedicine of Seville,5Hôpital Saint-André CHU and Department of Medical Oncology, Bordeaux University Hospital,6Department of Urology, Klinikum Rechts der Isar, Technical University Munich,7US Oncology Research, Comprehensive Cancer Centers of Nevada,8Genentech, Inc.,9Department of Medical Oncology, Netherlands Cancer Institute

Outcomes of everolimus + exemestane in ER+, HER2 neg, heavily pre-treated metastatic breast cancer: a real life multicentre experience

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Parth Desai1,Martin Hogg1
1Rosemere Cancer Foundation

Identification and characterisation of cyclic peptide inhibitors of Ras/PI3K and Ras/Raf protein complexes

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Mohamed Ismail1,Julian Downward1
1The Francis Crick Institute

Predicting oesophageal cancer progression using genomic information in pre-malignant oesophageal tissues

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Sarah Killcoyne1,Eleanor Gregson1,David Wedge2,Rachel de la Rue1,Ahmad Miremadi1,Matthew Eldridge3,Moritz Gerstung4,Rebecca Fitzgerald1
1University of Cambridge,2University of Oxford,3Cancer Research UK Cambridge Institute,4European Bioinformatics Institute

Factors associated with survival in lung cancer patients admitted to intensive care: an analysis of the West of Scotland Critical Care and Cancer Patient Database

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Christopher Grant1,Philip McLoone1,Billy Sloan1,Kathryn Puxty2,Tara Quasim2,David Morrison1
1University of Glasgow,2Glasgow Royal Infirmary

Differences in endometrial cancer molecular portraits based on ethnicity in The Cancer Genome Atlas

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David Guttery1,Kevin Blighe1,Konstantinos Polymeros2,Paul Symonds1,Salvador Macip1,Esther Moss1
1University of Leicester,2Univerisyt of Leicester

Predictors of patient-related delay of oral cancer diagnosis in Bangladesh

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Md Zahid Ullah1,Jennifer NW Lim2,Marie-Ann Ha1,Bas Bueno-de-Mesquita3
1Anglia Ruskin University,2University of Wolverhampton,3Imperial College London

Anti-metastatic effects of adrenergic analogues on the triple-negative breast cancer cell line, MDA-MB-231

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Alice Lee1,Mustafa Djamgoz1
1Imperial College London

PET-CT in gynaecology malignancy exenterations: a 5 year experience

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Jeffrey Lim1,Sebastian Smolarek2,Nagindra Das3,Kerryn Lutchman-Singh3
1Great Western Hospitals NHS Foundation Trust,2Plymouth Hospitals NHS Trust,3Abertawe Bro Morgannwg University Health Board

Epigenetic sensitisation of NSCLC Cells to Common Chemotherapy Agents

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Ghaliah Alnefaie1,Israa Al-Humairi1,Jason Parsons1,John Field1,Lakis Liloglou1
1University of Liverpool

Dietary Polyphenols Influence Antimetabolite Agents: Methotrexate, 6-Mercaptopurine and 5-Fluorouracil in Leukemia Cell Lines

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Amani Mahbub1,Dr Nicola Jordan-Mahy2,Dr Neil Cross2,Prof Christine Le Maitre2,Dr Sarah Haywood2
1Umm Al Qura University,2Biomolecular Sciences Research Centre, Sheffield Hallam University

Mammographic density in women with a previous breast cancer: case control study

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Shuk Yee Choo1,Elaine Harkness2,Soujanya Gadde3,Yit Y Lim4,Anthony J Maxwell5,D Gareth Evans6,Anthony Howell6,Susan Astley5

1University of Manchester Medical School,2Centre for Imaging Sciences, Institute of Population Health, University of Manchester. Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester. The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester,3Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester.,4Centre for Imaging Sciences, Institute of Population Health, University of Manchester. Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester.,5Centre for Imaging Sciences, Institute of Population Health, University of Manchester. Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester. The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester. Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Withington, Manchester.,6Nightingale Centre and Genesis Prevention Centre, University Hospital of South Manchester, Manchester. The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester. Manchester Breast Centre, Manchester Cancer Research Centre, University of Manchester, Christie Hospital, Withington, Manchester.


Patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies may inform prospective clinical trials

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Matt Alderdice1,Amy McCorry1,Claudio Isella2,Darragh McArt1,Susan Richman3,Dion Morton3,Philip Quirke3,Ultan McDermott3,Ian Tomlinson3,Graeme Murray3,Manuel Salto-Tellez1,Simon Gollins3,Richard Wilson1,Richard Adams3,Tim Maughan3,Enzo Medico2,Andrea Bertotti2,Mark Lawler1,Philip Dunne1
1Centre for Cancer Research and Cell Biology, Queen's University Belfast,2Università degli Studi di Torino,3Stratification in COloRecTal Cancer (S:CORT) Consortium

Association of circulating markers of immortality and cellular senescence with survival in advanced gastro-oesophageal adenocarcinoma patients

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Alan Bilsland1,Sofie Degerman2,Mattius Landfors2,Jennifer Walker3,Carol McCormick3,Eilidh McCulloch3,Liz-Anne Lewsley3,Antonia MacMillan4,Martin MacLeod5,Jamie Stobo3,James Paul3,Göran Roos2,T.R. Jeffry Evans3,Fiona Thomson3,W. Nicol Keith3
1University of glasgow,2Umea University,3university of glasgow,4University of Glasgow,5Beatson West of Scotland Cancer Centre