164 abstracts found.



Interim results from the IMPACT study: evidence for PSA screening in BRCA2 mutation carriers

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Rosalind Eeles1,Elizabeth Page2,Elizabeth Bancroft3,Mark Brook1,Melissa Assel4,Judith Offman5,Zsofia Kote-Jarai1,Andrew Vickers4,Hans Lilja4,The IMPACT study Steering Committee and IMPACT study collaborators6

1The Institute of Cancer Research, London, UK,2The Institute of Cancer Research,3Royal Marsden NHS Foundation Trust, London, UK,4Memorial Sloan Kettering Cancer Center, New York, US,5King’s College London, London, UK,6the Institute of Cancer Research

Non-invasive methylation test to detect cervical pre-cancer in self-collected vaginal and urine specimens

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Belinda Nedjai1,Caroline Reuter1,Toni Hollingworth1,Janet Austin1,Louise Cadman1,Jack Cuzick1,Attila Lorincz1

1Queen Mary University of London, London, UK

Prospective clinical validation of novel serum biomarker test for the identification of patients at risk of brain tumour.

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Paul Brennan1,Holly Butler2,Mark Hegarty3,Ben Smith2,David Palmer2,Michael Jenkinson4,Matt Baker5

1university of edinburgh,2University of Strathclyde,3Clin Spex Dx Ltd,4University of Liverpool,5university of Strathclyde

Occupational exposure and smoking adjusted risk of bladder cancer. Population based cohort studies in the Nordic countries.

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Kishor Hadkhale1,Jan Ivar Martinsen2,Elisabete Weiderpass3,Kristina Kjaerheim2,Par Sparen4,Laufey Tryggvadottir5,Elsebeth Lynge6,Eero Pukkala7,Tom K Grimsrud2
1Tampere University, Tampere, Finland,2Cancer registry of Norway, Oslo, Norway,3International Agency for Research on Cancer, Lyon, France,4Karolinska Institute, Stockholm, Sweden,5Icelandic cancer registry, Reykjavik, Iceland,6University of Copenhagen, Copenhagen, Denmark,7Finnish cancer registry, Helsinki, Finland

Verification of a Cartridge-based Microsatellite Instability (MSI) Platform and Cross-platform Assessment of Cases with Rare Germline Polymorphic Markers

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Gareth Gerrard1,Diana Pelka2,Nicole Gurunlian1,Georgina Briggs1,Jack Grant1,Kevin Balibi1,Phil Bennett1
1Sarah Cannon Molecular Diagnostics,2HCA Healthcare UK

Development and validation of a risk prediction model for lung cancer with common health examination indexes

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Zhangyan Lyu1,Ni Li1,Fengwei Tan1,Jiang Li1,Chunqing Lin1,Hongda Chen1,Jiansong Ren1,Jufang Shi1,Kai Su1,Fang Li1,Xiaoshuang Feng1,Luopei Wei1,Xin Li1,Yan Wen1,Gang Wang2,Shuohua Chen2,Shouling Wu2,Min Dai1,Jie He1
1National Cancer Center, Beijing, China, National Clinical Research Center for Cancer, Beijing, China, Cancer Hospital, Beijing, China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China,2Kailuan General Hospital, Tangshan, China

Acceptability of circulating microRNAs for testicular germ cell malignancy: validation of an initial user consultation exercise

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Lorna Fern1,Michelle Greenwood2,Sue Brand3,Dan Stark4,Mathew Murray5
1University College London Hospitals,2St Bartholomew's Hospital London,3It’s in the Bag,4University of Leeds,5Cambridge University Hospitals

NORAD2: an enhancer RNA that strongly activates DCBLD2 gene transcription upon drug treatment

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Andrei Zheltukhin1,Dmitry Karpov1,Pavel Spirin1,Olga Zinovieva1,Evgenia Grineva1,George Krasnov1,Tamara Mashkova1,Nikolai Lisitsyn1
1Engelhardt Institute of Molecular Biology

An Analysis of Prognostic Biomarkers of the Systemic Inflammatory Response in Cancers of Unknown Primary

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Rebekah Patton1,Rebekah Patton1,Gillian Knowles1,Rachel Haigh1,Lucy Dobbs2,Barry Laird1,Colin Barrie1,Sally Clive1
1NHS Lothian, Edinburgh, UK,2University of Edinburgh, Edinburgh, UK

Making Big Data available: Informatics Infrastructure supporting the MRC/CRUK funded Stratification in COloRecTal Cancer (S-CORT) programme

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Andrew Blake1,Enric Domingo1,Michael Youdell1,Susan Richman2,Peter Stewart3,Celina Whalley4,Clare Hardy5,Katerina Chatazipli5,on behalf of S-CORT Consortium6,Tim Maughan1
1University of Oxford,2University of Leeds,3Queens University Belfast,4University of Birmingham,5Wellcome Trust Sanger Institute,6S-CORT Consortium

Explaining socio-economic differences in bladder cancer survival

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Beth Russell1,Mieke Van Hemelrijck1,Truls Gårdmark2,Lars Holmberg1,Pardeep Kumar3,Andrea Bellavia4,Christel Häggström5
1King's College London, London, UK,2Karolinska Institute, Stockholm, Sweden,3Royal Marsden NHS Foundation Trust, London, UK,4Havard T.H Chan School of Public Health, Boston, US,5Uppsala University, Uppsala, Sweden

Radical (chemo)radiotherapy in a population-based dataset of real-world patients with oropharyngeal cancer: comparison of 7th and 8th staging systems

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Francesca De Felice1,Thomas Bird2,Andriana Michaelidou3,Selvam Thavaraj4,Edward Oddell4,Ann Sandison4,Gillian Hall4,Peter Morgan4,Andrew Lyons4,Luke Cascarini4,Alastair Fry4,Richard Oakley4,Ricard Simo4,Jean Pierre Jeannon4,Miguel Reis Ferreira4,Mary Lei4,Teresa Guerrero Urbano4
1Guy's and St Thomas' NHS Foundation Trust, London, Sapienza University of Rome, Rome, Italy,2Bristol Cancer Institute, Horfield Road, Bristol, BS2 8ED,3King's College London and Kent Oncology Centre,4Guy's and St Thomas' NHS Foundation Trust

Is pelvic examination a key part of a patient’s gynaecological cancer diagnostic journey? A qualitative study of GPs and specialists.

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Pauline Williams1,Maggie Cruickshank1,Christine Bond1,Christ Burton2,Peter Murchie1
1University of Aberdeen,2University of Sheffield

Quantitative secretomics analysis of stem and non-stem cells of two different stages of colon cancer cell lines

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Jeyalakshmi Kandhavelu1,Kumar Subramanian1,Previn Naicker2,Stoyan Stochev2,Paul Ruff1,Clement Penny1
1University of the Witwatersrand,2Council for Scientific and Industrial Research

Characterising novel patient tumour tissue-derived organoid models for in vitro research

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Ibrahim Khot1,Roberto Coppo2,Masahiro Inoue2,David Jayne1
1University of Leeds,2Kyoto University

A biobank analysis of outcomes in patients with malignancy of undefined primary origin

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Mark Stares1,Rebekah Patton1,Gillian Knowles1,Rachel Haigh1,Colin Barrie1,Lucy Dobbs2,Barry Laird2,Sally Clive1
1NHS Lothian,2Edinburgh University

Assessment of systemic metabolic biomarkers to predict prostate cancer progression and mortality

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Meda R Sandu1,Diana L. Santos Ferreira1,Rebecca Richmond1,Lucy Hackshaw-McGeagh1,Eleanor Walsh1,Michael Davis1,Emma Turner1,Freddie C. Hamdy1,The ProtecT study group2,J Athene Lane1,Richard M Martin1
1University of Bristol,2multiple

Assessment of tissue composition with digital pathology in colorectal cancer

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Enric Domingo1,Aikaterini Chatzipli2,Susan Richman3,Andrew Blake1,Claire Hardy2,Celina Whalley4,Keara Redmond5,Ian Tomlinson4,Philip Dunne5,Steven Walker6,Andrew Beggs4,Ultan McDermott2,Graeme Murray7,Leslie Samuel8,Matt Seymour3,Philip Quirke3,Tim Maughan1,Viktor Koelzer9
1University of Oxford, Oxford, UK,2Wellcome Trust Sanger Institute, Cambridge, UK,3Leeds Institute of Cancer and Pathology, Leeds, UK,4University of Birmingham, Birmingham, UK,5Queen's University Belfast, Belfast, UK,6Almac Diagnostics, Craigavon, UK,7University of Aberdeen, Aberdeen, UK,8Aberdeen Royal Infirmary, Aberdeen, UK,9University of Zurich, Zurich, Switzerland

Improving Outcomes For Immunotherapy-Induced Endocrinopathies in Metastatic Melanoma

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Christina Peters1,Carolyn Tang1,Joyce Ntata1,Yvette Moore1,Ankit Rao1,Poulam Patel1
1Nottingham University Hospitals NHS Trust

Survival outcomes in oropharyngeal cancer: a decision tree analysis

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Francesca De Felice1,Laia Humbert-Vidan2,Mary Lei2,Andrew King2,Teresa Guerrero Urbano2
1Guy's and St Thomas' NHS Foundation Trust, London, Sapienza University of Rome, Rome, Italy,2Guy’s and St Thomas’ NHS Foundation Trust, London, UK

Accurate targeted long-read DNA methylation sequencing with TAPS.

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Yibin Liu1,Yibin Liu1,Jingfei Cheng1,Paulina Siejka-Zielinska1,Chunxiao Song1
1University of Oxford

Could novel inhibition of acid ceramidase with LCL521 have a translatable role for locally advanced rectal cancer?

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Rachael Clifford1,Naren Govindarajah1,David Bowden1,Paul Sutton1,Aiping Bai2,Zdzislaw Szulc2,Besim Ogretmen2,Jason Parsons1,Dale Vimalachandran3
1Institute of Cancer Medicine, The University of Liverpool,2Medical University of South Carolina,3The Countess of Chester Hospital

Lung cancer survival in seven high-income countries 2010-2014: assessing the impact of stage at diagnosis by sex (the ICBP SURVMARK-2 project)

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Marzieh Araghi1,Miranda Fidler-Benaoudia2,Melina Arnold3,Eileen Morgan3,Mark Rutherford4,Freddie Bray3,Isabelle Soerjomataram3
1University College London,2Cancer Control Alberta,3International Agency for Research on Cancer (IARC/WHO),4University of Leicester

High plasmatic IL-8 and low nitrites levels are independent predictors of poor prognosis in nasopharyngeal carcinoma patients

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Ahmed Amine Zergoun1,Taha Merghoub2,Chafia Touil-Boukoffa3,Mehdi Bourouba3
1University of M'hamed Bougara, Boumerdes,2MSKCC,3USTHB

3-D cell culture models for detection of biomarker indicating anti-EGFR antibody resistance in colon cancer patients

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Jens Hahne1,Andrea Lampis1,Michele Ghidini2,Margherita Ratti2,Massimiliano Salati1,Chiara Senti2,Rodolfo Passalacqua2,Luciano Cascione3,Chiara Braconi1,Owen Sansom4,Matteo Fassan5,Nicola Valeri1
1The Institute of Cancer Research London,2Istituti Ospitalieri di Cremona,3Institute of Cancer Research Belinzola,4The Beatson Institute for Cancer Research,5University of Padua

Interferon-related signalling dictates prognosis in the fibroblast-rich subtype of stage II and III colon cancer

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Amy McCorry1,Rene Jackstadt2,Dustin Flanagan2,S:cort Consortium3,ACRCelerate Consortium4,Owen Sansom2,Mark Lawler1,Philip Dunne1
1Queen's University Belfast,2Cancer Research UK Beatson Institute,3S:CORT Consortium,4ACRCelerate

Neutrophil/Lymphocyte Ratio predicts resection margin status and lymphovascular invasion in patients with resectable oesophageal and gastric adenocarcinomas who received neoadjuvant FLOT.

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Danny Ulahannan1,Danny Ulahannan1,Konstantinos Kamposioras2,Jessica Tay3,George Papaxoinis4,Jeremy Hayden1,Dan Swinson1,Jonathan Wadsley3,Usman Ahmad5,Simon Brown6,Sohail Mughal6,Jo Dent7,Elizabeth Appleton7,Rajarshi Roy8,Ornella Belvedere9,Kim Last9,Mohan Hingorani1,Matt Seymour1
1Leeds Teaching Hospital,2Christie Hospital,3Weston Park cancer centre, Sheffield,4Agios Savvas Anticancer hospital, Athens, Greece,5Mid Yorkshire hospital NHS trust,6Bradford Teaching hospital,7Calderdale and Huddersfield NHS trust,8Hull University teaching hospital,9York teaching hospital

Mutation analysis of Beta2-Microglobulin identifies a subset of deficient mismatch repair (dMMR) colorectal cancers which are protected from disease recurrence.

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Susan Richman1,Paul Barrow2,Andrew Wallace3,Kelly Handley4,Gordon Hutchins5,David Kerr6,Laura Magill4,Gareth Evans3,Richard Gray6,Phil Quirke5,James Hill2
1Leeds Teaching Hospitals NHS Trust,2Manchester Royal Infirmary,3Central Manchester University Hospitals NHS Trust,4University of Birmingham,5University of Leeds,6University of Oxford

Expression of non-coding RNAs in early stage breast cancer and their prognostic implications

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Krishna Patel1,Arunagiri Kuha Deva Magendhra Rao2,Shirley Sundersingh2,Veluswami Sridevi2,Thangarajan Rajkumar2,Bipin Nair3,Akhilesh Pandey4,Aditi Chatterjee1,Samson Mani2,Harsha Gowda1
1Institute of Bioinformatics,2Cancer Institute (WIA),3Amrita Vishwa Vidyapeetham,4Mayo Clinic

SWATH mass spectrometry: Quantitative mapping of soft tissue sarcomas by digital proteome profiling

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Lukas Krasny1,Martina Milighetti1,Alexander T.J. Lee1,Aik-Choon Tan2,Robin Jones3,Paul H. Huang1
1The Institute of Cancer Research, London, UK,2University of Colorado, Aurora, US,3Royal Marsden Hospital, London, UK

Discovery of prognostic biomarkers from the prostate cancer membrane proteome using bioorthogonal chemistry.

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Lynn Asante-Asare1,Mike Deery2,Renata Feret2,Yagnesh Umrania2,Jodi Miller1,Cara Brodie1,Jo Arnold1,André Neves1,Kevin Brindle1
1Cancer Research UK Cambridge Institute,2Cambridge Centre for Proteomics

Concurrent and Future risk of Endometrial Cancer in women with Endometrial Hyperplasia: A systematic review and meta-analyses.

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Úna McMenamin1,Michelle Doherty2,Omolara Sanni2,Helen Coleman2,Chris Cardwell2,Glenn McCluggage3,Declan Quinn4,James Wylie4
1Queen's University Belfast, Belfast, UK,2Queen's University Belfast,3Belfast Health and Social Care Trust,4Northern Health and Social Care Trust

Non-Attendance in Two-week wait and Urgent Colorectal Cancer Referrals

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Vincenza Scanella1,Harpreet Sekhon Inderjit Singh2,Rabiya Aseem2,Jason Smith2,Nikhil Pawa2
1Imperial College London, London, UK,2West Middlesex University Hospital, Isleworth, UK

CT Scan to Screen for Occult Cancer in Unprovoked Venous Thromboembolism (VTE)

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CHUN WAI Wong1,Kelly Lim1,Rachel Garnett1,Harris Khan1,Faisal Solkar1,Shahab Abbas1
1ROYAL STOKE UNIVERSITY HOSPITAL

Oesophageal Cancer Diagnostics using Multi-Centre Raman Spectroscopy

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Martin Isabelle1,Catherine Kendall2,Nick Stone3,Geraint Thomas4,Gavin Lloyd2,Neil Shepherd5,Manuel Rodriguez-Justo4,Ian Bell1,Hugh Barr2
1Spectroscopy Products Division, Renishaw plc,2Biophotonics Research Unit, Gloucestershire Hospitals NHSFT,3Biomedical Spectroscopy, Physics and Astronomy, University of Exeter,4Department of Cell and Developmental Biology, University College London,5Gloucestershire Hospitals NHSFT

Top Ten Research Priorities in Cancer Early Detection: a priority setting partnership between patients and healthcare professionals

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Ellena Badrick1,Andrew Renehan1,Gen Buckley2,Lindsey Brown2,Katharine Cresswell,3,Phil Crosbie1,Clare Dickinson4,Patricia Elis5,Peter Hall6,James Leighton7,David Makin2,Lee Malcomson4,Richard Martin8,Rebecca Morris1,Helena O’Flynn9,Emma Thorpe4,Emma Crosbie1
1University of Manchester,2Public Contributor,3Manchester Foundation Trust,4Christie Hospital,5James Lind Alliance,6University of Edinburgh,7Greater Manchester Cancer,8University of Bristol,9NHS

Assessment of the role of the preoperative neutrophil-lymphocyte ratio as a prognostic biomarker in nonmetastatic rectal cancer

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Manar Almusarhed1,Osamah Al-Asadi1,Azhar Rizvi1,Anil Hermanad1,Qamar Zaman1,Somnath Mukherjee1,Hany Eldeeb1
1Milton Keynes Universiy Hospital

Integrating Germline and Somatic Genetic Test Result Data into the English National Cancer Registration and Analysis Service

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Fiona McRonald1,Brian Shand1,Sophia Richardson1,Katrina Lavelle1,Sally Vernon1,Caroline Brook1,Francesco Santaniello1,Joanna Pethick1,Margreet Luchtenborg1,Steven Hardy1,Jem Rashbass1
1National Disease Registration, Public Health England, London, UK

Elevated Parkinson’s-like tumour signalling from very early-stage colorectal cancer is associated with disease relapse

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Aoife McCooey1,Keara Redmond1,Emma Kerr1,Daniel Longley1,Philip Dunne1,S-cort Consortium2
1Queen's University Belfast,2S:CORT Consortium

Is gynaecological cancer stage affected by pre-referral pelvic examination: a linked data study?

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Pauline Williams1,Peter Murchie1,Maggie Cruickshank1,Christine Bond1,Chris Burton2,Dolapo Ayansina1
1University of Aberdeen,2University of Sheffield

Clinical utility of circulating microRNAs in malignant germ cell tumours

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Matthew Murray1,Nicholas Coleman1
1University of Cambridge, Cambridge, UK

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

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Korsuk Sirinukunwattana1,Enric Domingo1,Susan Richman2,Keara Redmond3,Andrew Blake1,Clare Verrill1,Simon Leedham1,Katerina Chatzipli4,Claire Hardy4,Celina Whalley5,Chieh-Hsi Wu1,Andrew Beggs5,Ultan McDermott6,Philip Dunne3,Angela Meade7,Steven Walker8,Graeme Murray9,Leslie Samuel10,Matt Seymour11,Ian Tomlinson5,Philip Quirke2,Tim Maughan1,Jens Rittscher1,Viktor Koelzer12
1University of Oxford,2University of Leeds,3Queen's University Belfast,4Wellcome Sanger Institute,5University of Birmingham,6AstraZeneca,7University College London,8Almac Group Ltd,9University of Aberdeen,10NHS,11NIHR,12University of Zürich

A novel capillary nano-immunoassay towards rapid, quantitative measurement of cell cycle biomarkers in clinical trials

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Eleanor Tiplady1,Krishna Yalla1,Eilidh McCulloch1,Alan Bilsland1,Kathrin Heinzmann2,Fiona Thomson1
1University of Glasgow,2Cancer Research UK

Methylation Sensitive High Resolution Melting (MS-HRM) Assay for the Detection of BRCA1 and BRCA2 Promoter Hypermethylation

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Diana Pelka1,Jack Grant1,Sasha Hansel1,David Moore1,Phil Bennett1,Geraldine Thomas2,Gareth Gerrard1
1Sarah Cannon Molecular Diagnostics, London, UK,2Imperial College London, London, UK

Applicability of routine targeted next generation sequencing to estimate tumour mutational burden (TMB) in patients treated with immune-checkpoint inhibitor therapy

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Heather Urus1,David Pinato2,Thomas Newsom- Davis3,Persephone Du Parcq4,Katherine Belessiotis2,Leah Mapara2,Nandita Gupta5,Danielle Power2,Justin Weir5,Ching N Wong1,Ragu P Ratnakumaran2,Jamshid Khorashad4,Kathy Dominy4,Mark Bower3
1Department of Surgery & Cancer, Imperial College London,2Department of Oncology, Imperial College NHS Trust,3Department of Oncology, Chelsea & Westminster Hospital,4Molecular Pathology Laboratory, Hammersmith Hospital,5Department of Histopathology, Imperial College NHS Trust

A multiplex proteomics analysis reveals a novel plasma biomarker signature that predicts for outcomes in gastro-oesophageal cancer

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Eilidh McCulloch1,Alan Bilsland1,Liz-Anne Lewsley2,Antonia MacMillan2,Martin MacLeod2,Jennifer Walker1,Jamie Stobo2,James Paul2,W. Nicol Keith1,Patricia Roxburgh1,Fiona Thomson1,T.R. Jeffry Evans1
1Glasgow ECMC, Institute of Cancer Science, University of Glasgow,2CRUK Clinical Trials Unit, Institute of Cancer Science, University of Glasgow

Renal cell carcinoma patients under 60 should be screened for colorectal carcinoma

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Joseph John1,Eleanor Burden2,Edward Smyth1,Adam Chambers1
1Taunton and Somerset NHS Foundation Trust, Taunton, UK,2Royal Devon and Exeter Hospital, Exeter, UK

Hospital activity before and after diagnosis of monoclonal gammopathy of undetermined significance (MGUS)

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Maxine Lamb1,Eleanor Kane1,Alexandra Smith1,Eve Roman1

1University of York, York, UK

Plasma levels of mammaglobin-A, VEGF and PlGF in human breast cancer pathology and 8-year survival

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Liz Baker1,Louise Hall2,Deborah Wilson1,Pud Bhaskar1
1North Tees and Hartlepool NHS Foundation Trust,2Royal Victoria Infirmary

T-stage migration by routine pre-biopsy MRI staging may affect risk assessment with current risk classification systems

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Na Hyun Kim1,Daniel Ball1,Taimur Shah1,Max Peters2,Saiful Miah3,Enrique Gomez4,David Eldred-Evans5,Hashim Ahmed3,Mathias Winkler3,Ashley McFarlane6
1Imperial College Healthcare,2University Medical Center Utrecht,3Charing Cross Hospital, Imperial Health and Imperial College London (ICL),4IMIBIC,5Imperial College London,6Imperial College Healthcare Trust