164 abstracts found.



One Year Results from a South Wales Rapid Diagnostic Clinic for Patients with Serious but Non-Specific Symptoms of Cancer

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Kieran Foley1,Balan Palaniappan2,Anthony Gibson2,Gareth Davies2
1Cardiff University,2Cwm Taf University Health Board

Predictive markers of survival in Acute Oncology patients seen in a large tertiary academic hospital: Neutrophil/Lymphocyte Ratio, Platelet/Lymphocyte Ratio and CRP

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Tess O'Neill1,Tim Benepal1,Anna-Mary Young1,Hiten Patel1,Lisa Pickering1,Christopher Anderson1,Mehran Afshar1
1St George's University Hospitals NHS Foundation Trust

The role of comorbidities in influencing timely cancer diagnosis: A systematic review of comorbidity-specific effects and underlying mechanisms

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Cristina Renzi1,Aradhna Kaushal1,Bernard Rachet2,Willie Hamilton3,Jo Waller1,Georgios Lyratzopoulos1
1UCL,2LSHTM,3Exeter University

Radiology review of MRI screening used to detect rSCC (radiological spinal cord/compression) in a randomised trial of asymptomatic castrate resistant prostate cancer patients with spinal metastasis.

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Aslam Sohaib1,Keeley Tomkinson2,Philip Rich3,Graeme Houston4,Clare Cruickshank2,Clare Griffin2,Shama Hassan2,Laura Wiley2,Stephanie Gibbs5,Ann Henry6,Gail Horan7,Heather Payne8,Ian Pedley9,Narayanan Nair Srihari10,Emma Hall2,David Dearnaley1
1Royal Marsden Hospital,2Institute of Cancer Research,3St Georges Hospital London,4University of Dundee,5Queen's Hospital Romford,6Leeds Teaching Hospital,7Addenbrooke's Hospital,8University College Hospital,9Newcastle Hospital,10Royal Shrewsbury Hospital

Longitudinal and Network Serum Biomarker Models for Early Detection of Ovarian Cancer

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John Timms1,Harry Whitwell1,Jenny Worthington1,Oleg Blyuss1,Aleksandra Gentry-Maharaj1,Andy Ryan1,Richard Gunu1,Jatinderpal Kalsi1,Usha Menon1,Ian Jacobs2,Alexey Zaikin1,John Timms1
1UCL,2UNSW

Developing Pharmacodynamic Biomarkers for Monitoring Response to Cdc7 Inhibitors in Patients

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Eleanor Tiplady1,Krishna Yalla1,Eilidh McCulloch1,Colin Nixon2,Alan Bilsland1,Sidath Katugampola3,Julie Stock3,Fiona Thomson1
1University of Glasgow,2Beatson Institute for Cancer Research,3Cancer Research UK Centre for Drug Development

The relationship between performance status, SIR, body composition, functional activity and survival in patients with advanced cancer

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Ross Dolan1,Ross Dolan1,Barry Laird2,Donald McMillan1,Paul Horgan1
1University of Glasgow Academic Unit of Surgery,2University of Edinburgh

The development of early warning diagnostic and treatment response markers of high grade serous carcinomas of the ovary/fallopian tube.

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Laura Feeney1,Sharon Eddie Parkinson2,Darren McArt2,Niamh O'Brien2,Ken Mills2,Manuel Salto-Tellez2,Richard Kennedy2,James Beirne2,Paul Mullan2
1CCRCB Queens University Belfast,2Queens University Belfast

The Yorkshire Lung Screening Trial

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Rhian Gabe1,Matthew Callister2,Phillip Crosbie3,Irene Simmonds2,Nazia Ahmed2,Richard Neal2,Samantha Quaife4,Puvan Tharmanathan1,Seb Hinde1
1University of York,2University of Leeds,3University of Manchester,4University College London

Reproducibility of magnetic resonance imaging radiomic features before and after androgen deprivation therapy in patients with high-risk prostate cancer

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Hannah Tharmalingam1,William Beasley2,Roberto Alonzi3,Jane Taylor4,Anwar Padhani4,Alan McWilliam2,Peter Hoskin3,Ananya Choudhury5
1University of Manchester, The Christie Hospital NHS Trust, Mount Vernon Cancer Centre,2University of Manchester,3Mount Vernon Cancer Centre,4Paul Strickland Scanner Centre,5The Christie Hospital NHS Trust

Metabolic Pathways and Cell Proliferation in the Advancing Front of Oropharyngeal Squamous Cell Carcinoma

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Khaled Ben Salah1,Asterios Triantafyllou2,Andrew Schache1,Richard Shaw1,Janet Risk1
1Department of Molecular & Clinical Cancer Medicine, University of Liverpool, UK,2Department pf Pathology, Liverpool Clinical Laboratories and School of Dentistry, University of Liverpool, Liverpool, UK

Performance characteristics of transrectal shear wave elastography (SWE) imaging in the evaluation of clinically localised prostate cancer

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Cheng Wei1,Chunhui Li1,Magdalena Szewczyk-Bieda2,Stephen Lang2,Dilip Upreti1,Zhihong Huang1,Ghulam Nabi1
1University of Dundee,2Ninewells Hospital

Obesity as a barrier to participation in breast screening – insights from Australia

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Kate McBride1,Catharine Fleming1,Emma George1,Genevieve Steiner1,Freya MacMillan1
1Western Sydney University

Alternative Fixative for Genome Friendly Tissue Handling to Implement Genomic Analysis in the 100,000 Genomes Project

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Clare Craig1,Emily Shaw2,Rachel Nelan3,Sally Smith4,Noor Jahan4,Victoria Hipperson4,Faisal Mihaimeed4,Shirley Henderson1,Miao He5,Zoya Kingsbury5,Lisa Browning6,Margaret Ashton-Key7,Afshan Siddiq1,Emma Walsh1,Kay Lawson1,Martina Mijiskovic1,Alona Sosinsky1,Greg Elgar1,Joanne Mason1,Tom Fowler1,James Brenton8,Mark Ross5,Louise Jones9
1Genomics England,2University Hospital Southampton NHS Trust,3Queen Mary University,4Barts Health NHS Trust,5Illumina,6Oxford Health NHS Foundation Trust,7Southampton University Hospital NHS Trust,8Cancer Research UK's Cambridge Institute,9Genomics England; Queen Mary University London and Barts Health NHS Trust

Tumour Cell Morphometrics Predict Survival in Lung Adenocarcinoma

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Najah Alsubaie1,David Snead2,Nasir Rajpoot3
1Department of Computer Science, University of Warwick, UK. Department of Computer Science, Princess Nourah University, KSA,2Department of Pathology, University Hospitals Coventry and Warwickshire, UK,3Department of Computer Science, University of Warwick, UK. Department of Pathology, University Hospitals Coventry and Warwickshire, UK. The Alan Turing Institute, UK

ROR1- A biomarker for chemoresistance in ovarian cancer.

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Eamaan Syed1,Frank Hills1,Britta Stordal1
1Middlesex University

Establishing the significance of TP53 and LKB1 co-mutations in KRAS-mutant lung cancer for prediction of checkpoint inhibitor response.

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Mathew Carter1,Ali Kia2,Rebecca Tay3,Philip Russell3,Andrew Wallace4,Katie Baker5,Lynsey Franklin5,Jane Rogan6,Matthew Krebs7,Raffaele Califano8,Yvonne Summers8,Fiona Blackhall8,Colin Lindsay8
1The Christie NHS Foundation Trust,2Faculty of Biology, Medicine and Health, The University of Manchester,3Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester,4Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester,5Clinical and Experimental Pharmacology Group, Cancer Research UK, Manchester Institute,6Manchester Cancer Research Centre Biobank, Manchester,7Experimental Cancer Medicine Team, The Christie NHS Foundation Trust & Division of Cancer Sciences, The University of Manchester, Manchester,8Department of Medical Oncology, The Christie NHS Foundation Trust & Division of Cancer Sciences, The University of Manchester, Manchester

Does the EndoPredict test improve decision making about adjuvant chemotherapy in early stage breast cancer?

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Lucy Matthews1,Shirley May1,David Bloomfield2,Valerie Jenkins1,Lesley Fallowfield1
1SHORE-C,2Brighton and Sussex University Hospitals

Automated Segmentation of Nucleus, Cytoplasm and Background of Pap-smear Images using a Trainable Pixel Level Classifier

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Wasswa William1
1Mbarara University of Science and Technology

The identification of a brown fat phenotype in colorectal cancer and its association with prognosis

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Graeme Murray1,Abdo Alnabulsi2,Beatriz Cash3,Ayham Alnabulsi3
1University of Aberdeen,2,3Vertebrate Antibodies

Performance Status, hypoalbuminemia and leucocytosis as prognostic factors for Cancer of Unknown Primary (CUP)

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Bradley Lonergan1,Marwan Bukhari1,David Fyfe1
1University Hospital of Morecambe Bay (UHMB) Trust

Pathways to diagnosis of a second primary cancer: a qualitative interview study

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Christine Campbell1,Annemieke Bikker1,Lovney Kanguru1,Debbie Cavers1,Karen Barnett2,David Weller3,David Brewster1
1University of Edinburgh,2University of Dundee,3Univeristy of Edinburgh

TGF beta dependent Epithelial to Mesenchymal Transition (EMT) in 3D spheroid models of ovarian cancer cells

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Thasni Kardeath1, Ikhlak Ahmed1, Wafaa Al Ameri1, Fatima Al-Dasim1, Joel Malek1

1weill cornell medicine- qatar


Investigating radioresistance in non-small cell lung cancer: Assessing the potential role for alkaline comet assay as a single end-point tool in guiding radiotherapy treatment and prognosis.

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Rick Karsan1
1University Hospital of Wales

METASTATIC DISEASE REPRESENTATION- AN ANALYSIS OF 148 PAIRED COLORECTAL CANCER LYMPH NODE METASTATIC TUMOUR DEPOSITS

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Thomas Starkey1,Tessa Sandberg2,Ian Tomlinson2,Lennard YW Lee2
1,2Institute of Cancer Sciences, University of Birmingham

Attitudes towards faecal immunochemical testing in patients at increased risk of colorectal cancer in primary care: a survey of English General Practitioners.

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Christian von Wagner1,Sandro Stoffel2,Helga Laszlo2,Brian Nicholson3,Jessica Sheringham2,Dorothy Szinay2,Yasemin Hirst2
1University College London,2UCL,3Nuffield Department of Primary Care

Evaluating the impact of the NHS Breast Screening Programme on breast cancer incidence: a case-control study

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Oleg Blyuss1,Dharmishta Parmar1,Nathalie J. Massat1,Jack Cuzick1,Peter D. Sasieni1,Stephen W. Duffy1
1Queen Mary University of London

Magnetic resonance imaging in accurate TNM staging of rectal cancer – can we live up to the Royal Marsden standard?

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Nsiah Yvonne1,Ahmad Zia2,Philip Garwood2,Amdad Ahmed2,Brendan McIlroy2,Edmund Leung2
1West Midlands Deanery,2Hereford County Hospital

Role of DYRK2 in invasive ductal carcinoma of the breast

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Jean Quinn1,Phungern Khongthong1,Donald McMillan1,Laureano de la Vega2,Joanne Edwards1
1university of glasgow,2university of Dundee

Ethnic differences in prostate cancer: Improving clinical outcomes

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Byiravey Pathmanathan1,Deepak Batura2,Gaurav Mukerji2,Omar Mohamed2,Giles Hellawell2
1Imperial College Healthcare NHS trust,2London North West University Healthcare NHS trust

Kinomic profiling of resected cholangiocarcinoma reveals patient and subtype specific patterns of targetable kinase activation

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David Britton1,Arran Dokal1,Shirin Khorsandi2,Ryan Smith1,Saul Teijeiro1,Vinothini Rajeeve Rajeeve1,Nigel Heaton2,Pedro Cutillas1
1BARTS CANCER INSTITUTE, QMUL,2King's College Hospital

Presenting symptoms and time to presentation among teenagers and young adults diagnosed with cancer: findings from the BRIGHTLIGHT cohort

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Minjoung Monica Koo1,Georgios Lyratzopoulos1,Annie Herbert1,Rachel Taylor2,Julie Barber1,Faith Gibson3,Jeremy Whelan2,Lorna Fern2
1UCL,2University College London Hospitals NHS Foundation Trust,3Great Ormond Street Hospital for Children NHS Foundation Trust

The influence of aortic calcification on outcome following rectal cancer resection.

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Kate Boland1,Katrina Knight1,James Park1
1University of Glasgow

Characterising the metabolic fate of (2S, 4R)-4[¹⁹F]-fluoroglutamine in cancer cells using ¹⁹F-MRS

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Nhat Nguyen1,Andreas Doepner1,Graham Smith1,Yuen-Li Chung1
1The Institute of Cancer Research

Diagnosis of usual ductal hyperplasia, atypical ductal hyperplasia and low grade ductal carcinoma in situ using copy number alterations

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Tanjina Kader1,Prue Hill2,Richard Young3,G.bruce Mann4,Ian Campbell1,Kylie Gorringe3
1Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne,The Sir Peter MacCallum Department of Oncology, University of Melbourne,2Department of Anatomical Pathology, St Vincent's Hospital,3The Sir Peter MacCallum Cancer Centre,4The Breast Service, The Royal Women's Hospital

Phenome-wide association study of pancreatic cancer using summary genetic data

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Ryan Langdon1,Rebecca Richmond1,Gibran Hemani1,Jie Zheng1,Kaitlin Wade1,Robert Carreras2,Mattias Johansson2,Paul Brennan2,George Davey-Smith1,Caroline Relton1,Richard Martin1,Emma Vincent1,Philip Haycock1
1University of Bristol,2IARC

TP53 mutation status strongly correlates with protein expression in a subset of patients enrolled in the FOCUS4 clinical trial.

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Susan Richman1,Gordon Hutchins2,Gemma Hemmings2,Phil Quirke2
1Leeds Teaching Hospitals NHS Trust,2University of Leeds

Exploring the barriers and facilitators to uptake of colorectal screening within ethnic minority groups

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Lenoj Kanageswaran1,Nikhil Pawa2
1Imperial College, London,2Chelsea and Westminster Hospitals NHS Trust

Automatic Quantification of Lung Adenocarcinoma Growth Patterns Predicts Five-Year Survival

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Najah Alsubaie1,David Snead2,Syed Ali Khurram3,Nasir Rajpoot4
1Department of Computer Science, University of Warwick, UK. Department of Computer Science, Princess Nourah University, KSA,2Department of Pathology, University Hospitals Coventry and Warwickshire, UK,3School of Clinical Dentistry, University of Sheffield, Sheffield,4Department of Computer Science, University of Warwick, UK. Department of Pathology, University Hospitals Coventry and Warwickshire, UK. The Alan Turing Institute, UK

Association of Vitamin D receptor and group-specific component gene polymorphisms with prostate cancer

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Farhad Mashayekhi1,Alireza Lotfabadi2
1University of Guilan, Rasht,2University of Guilan, Iran

Mitochondrial DNA sequence variations in uveal melanoma

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Amit Sharma1,Margarete Odenthal2,Frank Holz1,Solange Landreville3,Michael Zeschnigk4,Karin Loeffler1,Martina Herwig-Carl1
1University of Bonn,2University of Cologne,3Centre de recherche du CHU de Québec-Université Laval,4University of Duisburg, Essen

A novel blood-based biomarker for OAC with the potential for use as an early treatment response predictor.

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Rachel Lawrence1,Lucy Swithenbank2,Hasan Haboubi2,Lisa Williams3,Sarah Gwynne3,Shareen Doak4,Gareth Jenkins2
1Swansea University Medical school,2Swansea University medical school,3ABMU NHS Trust,4Swnasea University medical school

Improving the intra-operative diagnosis of high-grade glioma using a fluorescence biomarker – result of the UK NCRI GALA-BIDD study

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Colin Watts1,Keyoumars Ashkan2,Michael Jenkinson3,Kathreena Kurian4,Wendi Qian5,Stephen Price5,Tomasz Matys6,Gail Doughton5,Andrea Machin5,Josephine Jung2,Ibrahim Jalloh3,Chloe Harman5,Katrina Gatley5,Gemma Young5,Richard Hardy5,Alimu Dayimu7

1University of Birmingham,2Kings College Hospital,3University of Liverpool,4Southmead Hospital,5Cambridge University Hospitals NHS Foundation Trust,6University of Cambridge,7Shandong University


Rates of Symptomatic and Incidentally found Non Haematological Malignancies made in New Patients Referrals to the Haematology clinic over a 5 year period

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Andrew Fyfe1
1NHS Lanarkshire

The impact of sarcopenia on mortality following elective colorectal cancer resection.

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Daniel Dolan1,Katrina Knight1,Susan Moug2
1University of Glasgow,2NHS Greater Glasgow & Clyde

Integrating Genomic Medicine into the Routine Cancer Diagnostic Pathway – Role of the Manchester Cancer Research Centre Biobank and the 100k Genomes Project in Manchester, UK

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Jane Rogan1,John Radford2,Anshuman Chaturvedi3
1Manchester Cancer Research Centre,2The University of Manchester,3The Christie NHS Foundation Trust

Circulating Tumor DNA Analysis to Help Investigate Cancers at Risk of Failing Therapy – A Study in Advanced Stage Lung Adenocarcinoma

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Xiaoju Max Ma1,Christine Ju1,Liu Xi1,Stephanie Yaung1,Aarthi Balasubramanyam1,Nalin Tikoo1,Dan Klass1,Michael Thomas2,Felix Lasitschka2,Michael Meister2,Marc Schneider2,Felix Herth2,Thomas Muley2,Andrew Livingston3,Birgit Wehnl4,John F Palma1
1Roche Sequencing Solutions, Inc,2Thoraxklinik at Heidelberg University Hospital, Röntgenstr. 1, 69126 Heidelberg, Germany,3Roche Diagnostics Limited, Charles Avenue, Burgess Hill, West Sussex, RH15 9RY, United Kingdom,4Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany

Long-term effect of breast symptoms reported at mammography screening visit on cancer incidence and mortality

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Deependra Singh1,Joonas Miettinen2,Nea Malila2,Ahti Anttila2
1University of Tampere,2Finnish Cancer Registry

Tracking ‘developing’ Focal Densities in Breast Quadrants

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Faraz Janan1,Faraz Janan1,Michael Brady2
1University of Lincoln,2University of Oxford

Socio-demographic variation in stage at diagnosis and its population impact: How many cancer patients would be diagnosed at an earlier stage if socio-demographic inequalities were eliminated?

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Matthew Barclay1,Gary Abel2,Brian Rous3,David Greenberg3,Georgios Lyratzopoulos4
1University of Cambridge,2University of Exeter,3Public Health England,4University College London