26 abstracts found.



‘We’ve just had to hit the ground running’: Health professionals’ experiences of cancer immunotherapy: A qualitative study

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Stephen Jennings, Tessa Watts, Sally Anstey, Janet Bower

CALIBRATION: Can early changes in circulating tumour DNA (ctDNA) predict durable tumour responses in patients with advanced Oesophageal Adenocarcinoma receiving anti PD-L1 antibody durvalumab?

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Constanza Linossi, Gabriel Funingana Ionnut, Michelle Petruzzelli, Bruno Rala De Paula, Maria O'Donovan, Andrea Machin, Sarah Hewitt, Alexandra L Williams, Nicola Grehan, Aisling Redmond, Elizabeth Smyth, Richard Baird, Edmund M. Godfrey, Massimiliano Di Pietro, Iris Faull, Simon Dovedi, Rebecca C. Fitzgerald, Simon Pacey

Immune responses in pancreatic cancer may be restricted by prevalence of activated regulatory T-cells, dysfunctional and senescent T-cells

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Shivan Sivakumar1, Enas Abu-Shah, David Ahern, Edward Arbe-Barnes, Nagina Mangal, Srikanth Reddy, Aniko Rendek, Alistair Easton, Elke Kurz, Michael Silva, Zahir Soonawalla, Lara Heij, Rachael Bashford-Rogers, Mark Middleton, Michael Dustin
1University of Oxford

Measurement of pembrolizumab drug levels and anti-drug antibodies: real-world data from two centres

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Laura Wilkins, Sarah C. Sasson, Anna Olsson-Brown, Carol Jolly, Robert Watson, Paul Klenerman, Oliver Brain, Ben Fairfax

RAS orchestrates the increase of interstitial adenosine in lung adenocarcinoma to promote immune evasion

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Sophie de Carné Trécesson, Jesse Boumelha, Chris Moore, Deborah Caswell, Mariana Silva dos Santos, James MacRae, Edurne Mugarza-Strobl, Miriam Molina-Arcas, Paul Smith, Kris Sachsenmeier, Charles Swanton, Philip East, Julian Downward

The prognostic role of biomarkers of systemic inflammation for metastatic renal cell carcinoma patients who undergo cytoreductive nephrectomy

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Jigi Moudgil-Joshi, Mark Stares, Alex Laird, Steve Leung, Jahangeer Malik, Aravind Sundaramurthy, Stefan Symeonides

Radiation and DMXAA limit tumour development in a urethane-induced lung cancer model through inflammatory response

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Kay Shigemori, Yanyan Jiang, Stephen Stribbling, Jennifer C. Martin, Luiza H.M. Lourenco, Anderson J. Ryan

Playing Hide and Seek with Glioblastoma: Using epigenetic modulators to increase Cancer Testis and Neoantigen expression

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Ruichong Ma, Margarida Rei, Katherine Ferris, Isaac Woodhouse, Hashem Koohy, Puneet Plaha, Vincenzo Cerundolo

CD4 and CD8 T-cells contribute to the efficacy of the T-cell redirecting antibody CEA-TCB and TGFβ dampens its activity in in vitro colorectal cancer models

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Maria Semiannikova, Alice Newey, Fredrik Wallberg, Marina Bacac, Alan Melcher, Naureen Starling, David Cunningham, Ben Challoner, Andrew Woolston, Louise Barber, Marco Gerlinger

Characterising the peripheral myeloid response to immune checkpoint blockade

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Rosalin Cooper, Isar Nassiri, Robert A Watson, Chelsea Taylor, Elise A Mahé, Sara Danielli, Benjamin P Fairfax

Deconvolution of global gene expression profiles identifies differentially expressed immune-related gene profiles on aromatase inhibitor-resistant estrogen receptor positive tumours

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Milana Bergamino Sirvén1, Gabriele Morani, Joel Parker, Gene Schuster, Elena López-Knowles, Judith Bliss, Mitch Dowsett, Maggie Cheang
1Institute of Cancer Research (ICR)

Stratification of Non-Small-Cell Lung Cancer patients by PD-L1 Expression across Four NHS Trusts

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John Jackson, Mary Jones, Emma Valentine, Elizabeth Toy, Nicole Dorey, Manish Powari

Eosinophils are critical for response to immune checkpoint blockade in breast cancer and other cancer types

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Hannah Garner, Olga Blomberg, Lorenzo Spagnuolo, Leonie Voorwerk, Ewald van Dyk, Myriam Chalabi, Olga Isaeva, Noor Bakker, Kelly Kersten, Chris Klaver, Maxime Duijst, Dorien Pastoors, Cheei-Sing Hau, Kim Vrijland, Elisabeth Raeven, Louisa Hoes, Willemijn Theelen, Paul Baas, Emile Voest, Lodewyk Wessels, Karin de Visser, Marleen Kok

Development of a first-in-class Arginase 2 inhibitory monoclonal antibody that restores T cell proliferation in vitro

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Stuart W Haynes, Mark Austin, Denise Chan, Lesley Jenkinson, Agata Diamandakis, Daniel Burschowsky, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise Slater, Ellen Gowans, Yoko Shibata, Michelle Barnard, Robert Wilkinson, Tristan Vaughan, Fiona MCLAUGHLIN, Sarah Holt, Vincenzo Cerundulo, Mark Carr, Maria Groves

Retrospective review of the efficacy and tolerability of neoadjuvant biosimilar Trastuzumab (Herzuma) in combination with Pertuzumab and chemotherapy in HER2-positive early breast cancer.

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Ciara Martin1, Nadia Searle, Caroline Wilson, Alice Shaw
1University of Sheffield

Thyroid toxicities of Immune checkpoint inhibitors, Experience from Emirate of Dubai, UAE

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Mohamed Omara, Muhammad Latif, Elamin Abdelgader, Fatheya Alawadi, Faraz Khan, Maroun Elkhoury, Dalia Elshourbagy, Dina Hamza, S Hammad Tirmazy

Atezolizumab and Pembrolizumab Immunotherapy in the treatment of metastatic urothelial cancers – real world experience in Devon and Cornwall.

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Hannah Bond, Frances Mark, Rachel Wilkinson, Jennifer Hanks, Peter Sankey, Anna Lydon, Denise Sheehan, John Mcgrane

How do we manage brain metastases in the real world setting for patients with metastatic melanoma receiving immune checkpoint inhibition? Our experience within the North East of England.

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Abigail Gault, Nicola Cresti, Ruth Plummer

Clinical correlates of peripheral T cell immune awakening

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Zena Salih, Sara Valpione, Antonia Banyard, Joshua Tweedy, Elena Galvani, Philippa Middlehurst, Sarah Mills, John Weightman, Avinash Gupta, Paul Lorigan, Nathalie Dhomen, Richard Marais

Macrophages Mediate Response to PARP Inhibitor Treatment in Homologous Recombination-Proficient High-Grade Serous Ovarian Cancer

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Josip Vrancic, Susan Mason, Suzanne Dowson, Anna Kilbey, Sergio Lilla, Sara Zanivan, Iain McNeish, Karen Blyth, Seth Coffelt, Patricia Roxburgh

Outcomes for Advanced Non-Small Cell Lung Cancer Patients Treated with First-line Palliative Chemoimmunotherapy

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Elinor Gatfield1, Sini Shah, Carrie Morgan, Elspeth Saunders, Sunil Skaria, Dakshinamoorthy Muthukumar
1Addenbrooke's Hospital

Cancer Catabolism reflected by Prognostic Nutritional Index (PNI) is a better predictor of prognosis in early bladder cancers than Systemic Inflammation measured by Neutrophil Lymphocyte Ratio (NLR)

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Jessica Davies, Santhanam Sundar

Treatment of Immune-related adverse events secondary to immune checkpoint inhibitors in patients with Metastatic Melanoma associated with Improved Overall Survival

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Conor O'neill, Therese McCartney, Rebecca Gregory, Judith Carser

Learning about immune-checkpoint inhibitors (ICI) – time for change

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Rebecca Squires1, Jessica Ball, Christopher Herbert, Gemma Shaw, Hannah Taylor, Nick Leney, Helen Winter
1University Hospitals Bristol NHS Foundation Trust

The toxicity burden of Immune-checkpoint inhibitors: A single centre experience.

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Jessica Ball, Christopher Herbert, Hannah Taylor, Gemma Shaw, Helen Winter

Clinical implications of the MHC class I chain-related A (MICA) variants in gastric adenocarcinoma.

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Karen Toledo, Carolina Ribeiro, María Andrea Canals, Patricio González, Valentina Garate, Ricardo Armisen, Maria Carmen Molina