305 abstracts found.



Automatic 3D Segmentation of Head and Neck Tumours and Cancerous Lymph Nodes

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Baixiang Zhao1,John Soraghan1,Gaetano Di-caterina1,Derek Grose2
1university of strathclyde,2Beatson West of Scotland Cancer Centre

PRIMUS 002: An umbrella phase II study examining two neo-adjuvant regimens (FOLFOX-A and AG) in resectable and borderline resectable Pancreatic Ductal AdenoCarcinoma (PDAC)

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Derek Grose1,Colin McKay2,Nigel Jamieson3,Janet Graham1,David McIntosh1,Fraser Duthie3,Ganesh Radhakrishna4,Dave Colville1,Aileen Dufton1,Peter Houston1,Maria Hawkins5,Rebecca Goody6,Reena Ravikumar7,James Paul8,Jamie Stobo8,Susie Cooke3,Sarah Bradley8,Judith Dixon-Hughes3,Andrew Biankin3,David Chang3
1Beatson West of Scotland Cancer Centre,2West of Scotland Pancreatic Unit, Glasgow Royal,3University of Glasgow,4University of Manchester, Division of Cancer Sciences,5CRUK MRC Oxford Institute for Radiation Oncology,6Leeds Teaching Hospitals NHS Trust,7King’s College Hospital, London,8CRUK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow

A systematic review of outcome reporting in early phase studies of colorectal cancer surgical innovation

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Christin Hoffmann1,Kerry NL Avery1,Shelley Potter2,Nicholas Wilson1,Rhiannon Macefield1,Natalie Blencowe3,Sean Cousins1,Jane M Blazeby1,Angus GK McNair4
1Centre for Surgical Research, Bristol Medical School: Population Health Sciences, University of Bristol,21 Centre for Surgical Research, Bristol Medical School: Population Health Sciences, University of Bristol; 2 Bristol Breast Care Centre, North Bristol NHS Trust, Bristol, UK,31 Centre for Surgical Research, Bristol Medical School: Population Health Sciences, University of Bristol; 2 Division of Surgery Head and Neck, University Hospitals Bristol NHS Foundation Trust, Bristol, UK,41 Centre for Surgical Research, Bristol Medical School: Population Health Sciences, University of Bristol; 2 Department of Gastrointestinal Surgery, North Bristol NHS Trust, Bristol, UK

Impact of lung and cardiac dose on the survival of oesophageal cancer patients following single modality radiotherapy

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Matthew Hatton1,Bilal Tahir2,Helen Joyce3,Lynne Dixon3,Joseph Bradshaw4,Selina Hardy4,Stephen Tozer-Loft4,Jon Wadsley5
1Weston Park Hospital,2Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, UK,3Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK,4Department of Radiotherapy Physics, Weston Park Hospital, Sheffield, UK,5Academic Unit of Clinical Oncology, University of Sheffield, Sheffield

Estimating the gap in the provision of specialist cancer nurses in England

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Rachel White1,Jacqueline Goodchild1
1Macmillan Cancer Support

Should major surgery be offered to elderly patients with early-stage lung cancer? An emulated trial using observational data in England

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Camille Maringe1,Clémence Leyrat1,Sara Benitez Majano1,Aimilia Exarchakou1,Matthew Smith1,Bernard Rachet1,Aurélien Belot1
1London School of Hygienen and Tropical Medicine, London, UK

Assessment of the Outcome of Treating Spinal Oligometastases with Stereotactic Ablative Body Radiotherapy

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Helen Saxby1,Veni Ezhil2
1Charing Cross Hospital,2Royal Surrey County Hospital

Body composition and chemotherapy toxicity in women with early breast cancer: The Cando-3 study

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Ramsey Cutress1
1Faculty of Medicine, University of Southampton

PARP inhibition causes replication stress in preclinical models of high risk neuroblastoma and synergises with inhibition of ATR

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Harriet Southgate1,Nicola J Curtin1,Deborah A Tweddle1
1Newcastle University, Newcastle, UK

Patient recruitment for observational and interventional research studies in anal cancer in Leeds, England for 2013-2018

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Robert Samuel1,David Sebag-Montefiore2,Katie Spenver1,Alex Gilbert1,Nathalie Casanova3,Rachel Cooper3,Louise Loughman3,Pamela Shuttleworth3
1University of Leeds,2Universit of Leeds,3Leed University Teaching Hospitals NHS Foundation Trust

Predicting platinum chemotherapy sensitivity in advanced oesophageal cancer using a DNA Damage Immune Response (DDIR) assay

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Mark Baxter1,Shaun Walsh2,Russell Petty1
1University of Dundee,2NHS Tayside

Assessment and monitoring of cardiotoxicity in Breast Cancer patients treated with  HER2-directed Agents (Trastuzumab, Pertuzumab, and Ado-trastuzumab emtansine (T-DM1)

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Sudha Karanam1,Mariam Jafri1,Daniel Rea1,Nyein Su Tun1
1University Hospital Birmingham NHS Trust

Combining tyrosine kinase inhibitors with novel thiosemicarbazone iron chletors in cell lines derived from pediatric solid tumors of neurogenic origin

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Maria Krchniakova1,Jakub Neradil1,Silvia Chovanova1,Petr Chlapek1,Des. R. Richardson2,Jaroslav Sterba3,Renata Veselska1
1Masaryk University,2University of Sydney,3University Hospital Brno

Making Outcome-Based Payment for Cancer Medicines a Reality in the NHS

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Amanda Cole1,Patricia Cubi-Molla1,Jack Pollard2,Duncan Sim3,Richard Sullivan4,Jon Sussex2,Paula Lorgelly4
1Office of Health Economics, London, UK,2RAND Europe, Cambridge, UK,3Cancer Research UK, London, UK,4King's College London, London, UK

Repurposing loperamide to overcome gefitinib resistance by triggering apoptosis independent of autophagy induction in KRAS mutant NSCLC cells

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Christy Wing Sum Tong1,Mia Mingxia Wu1,Wei Yan1,Kenneth Kin Wah To1
1The Chinese University of Hong Kong

Cachexia-related biomarkers predict shortened survival and treatment-related adverse outcomes in a population receiving palliative chemotherapy for lung cancer

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Joanna Bowden1,Linda Williams2,Amanda Swan3,Richard Skipworth4,Marie Fallon2
1NHS Fife, Kirkcaldy, UK, University of Edinburgh, Edinburgh, UK, University of St Andrews, St Andrews, UK,2University of Edinburgh, Edinburgh, UK,3NHS Fife, Kirkcaldy, UK ,4NHS Lothian, University of Edinburgh, Edinburgh, UK

ADSCaN: A Randomised Phase II study of Accelerated, Dose escalated, Sequential Chemo-radiotherapy in Non-Small Cell Lung Cancer (NSCLC)

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Claire Lawless1,Kathleen Boyd2,Corinne Faivre-Finn3,John Fenwick4,Tom Haswell5,David Landau6,Jason Lester7,Joe Maguire8,Elaine McCartney1,Jim Paul1,Matthew Hatton9

1CRUK Clinical Trials Unit, Beatson West of Scotland Cancer Centre, Glasgow, UK,2Health Economics & Health Technology Assessment, University of Glasgow, Glasgow, UK,3The Christie NHS Foundation Trust, Manchester, UK,4Gray Institute of Radiation Oncology & Biology, University of Oxford, Oxford, UK,5West of Scotland Cancer Research Consumer Panel, Glasgow, UK,6Guys & St Thomas NHS Trust, London, UK,7Velindre Cancer Centre, Cardiff, UK,8Clatterbridge Cancer Centre, Liverpool, UK,9Weston Park Hospital, Sheffield, UK


The continual reassessment method for phase I clinical trial design: is it always more efficient than the 3+3?

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Samantha Hinsley1
1Clinical Trials Unit, Cancer Research UK, Glasgow, UK

Neoadjuvant FOLFOXIRI for colorectal cancer – a single-centre retrospective study of outcomes

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Kimberley Durno1,Daniel Krell1,Hemal Ariyaratne1
1Royal Free London NHS Foundation Trust

Segmentation of Head and Neck Cancer from MRI Data using Deep Neural network

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Baixiang Zhao1,John Soraghan1,Gaetano Di-caterina1,Derek Grose2
1university of strathclyde,2Beatson West of Scotland Cancer Centre

Incidence and management of 3 years of immune mediated toxicities in metastatic non-small cell lung carcinoma (NSCLC) patients treated with anti PD-1/PD-L1 immunotherapy

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Grace Tze-en Ding1,Colin Barrie1,Alan Simms2,Melanie Mackean3
1Edinburgh Cancer Centre,2Department of Radiology, NHS Lothian,3Edinburgh

Novel mechanisms of overcoming apoptotic resistance in Pancreatic Cancer

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Julie Nicoll1,Daniel Longley1,Chris Scott1
1CCRCB, Queen's University Belfast

Overcoming sorafenib resistance in hepatocellular carcinoma by fasting

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Jelena Krstic1,Isabel Reinisch1,Maria Depaoli1,Natascha Berger2,Christoph Noessing3,Markus Galhuber1,Ines Anders4,Martina Auer1,Elisabeth Moyschewitz1,Beate Rinner5,Martin Pichler6,Roland Malli1,Andreas Prokesch1
1Medical University of Graz, Graz, Austria, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Graz, Austria,2Department of Obstretics and Gynaecology, Medical University of Graz, Graz, Austria,3Cancer Research UK Beatson Institute, London, UK,4Medical University of Graz, Graz, Austria, Core Facility Alternative Biomodels and Preclinical Imaging, Graz, Austria,5Division of Biomedical Research, Medical University of Graz, Graz, Austria,6Division of Oncology, Medical University of Graz, Graz, Austria

Antiproliferation and anti-invasion of 1’-Acetoxychavicol acetate on hormonal-resistant breast cancer cells

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Nalinee Pradubyat1,Wannarasmi Ketchart2,Carlo Palmieri3,Athina Giannoudis4
1University of Liverpool,2Faculty of Medicine, Chulalongkorn University,3Institute of Translational Medicine, University of Liverpool, Clatterbridge Cancer Centre, UK,4Institute of Translational Medicine, University of Liverpool

Evaluation of older patients in early phase clinical trials

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Jessica Lowe1,Rosie Lauste2,Tine Descamps3,Matthew Krebs1,Donna Graham1,Fiona Thistlethwaite1,Louise Carter1,Natalie Cook1
1The Christie NHS Foundation Trust, Manchester, UK,2University of Manchester, Manchester, UK,3Cancer Research UK, London, UK

CEBOC: Evaluation of the safety of Cediranib in the prevention of Bowel perforation in platinum-resistant Ovarian Cancer

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Ann White1,Andrew Clamp2,Robert Morgan2,Dilly Goonetilleke3,Angela Casbard4,Tracie-Ann Madden4,Jennifer Swettenham4,Alkesh Patel2,Charlotte Wilhelm-Benartzi4,Catherine Rogers2,Gordon Jayson2
1,2The Christie NHS Foundation Trust,3The University of Manchester,4Cardiff University

Factors associated with Emergency Admissions for Cancer Patients in Last year of life in a UK region

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Victoria Cairnduff1,Laura Dwyer1,Colin Fox1,Gregory Fallica2,Kelly Shiell-Davis3,Anna Gavin1
1Northern Ireland Cancer Registry, Belfast, UK,2Macmillan Cancer Support,3Macmillan Cancer Support, London, UK

Standardised SACT consent forms improve patient understanding of their treatment intent

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Iman Ahmed Ainuddin1,Sally Clive2
1University of Edinburgh,2Edinburgh Cancer Centre

Identifying blood bio-markers for immunotherapy toxicity in melanoma patients

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Anna Olsson-Brown1,Charlotte Hogg1,Marie Allirajah1,Joseph Hanna1,Tsz Hin Lo1,Anusha Yoganathan1,Umair Akbani1,Helen Wong2,Marie McKay3,Shien Chow3,Joseph Sacco2
1University of Liverpool,2University of liverpool,3Clatterbridge Cancer Centre

Investigating the role of NF-κB/RelA in hypoxia induced stemness and EMT characteristics using NF-κB overexpression and CRISPR/Cas9- knockout models of glioblastoma cells.

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Samna Sagadevan1,Ben Smith1,Vinodh Kannappan1,Sathishkumar Kurusamy1,Karim Azar1,Weiguang Wang1
1University of Wolverhampton

The direct and indirect effects of affluence on survival in colon cancer: A population-based study

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Rosie Dew1,Jonathan Pratschke2,Louise Hayes1,Linda Sharp1
1Newcastle University,2University of Naples "Federico II"

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

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Matthew J. Sale1,Emma Minihane1,Noel R. Monks2,Rebecca Gilley1,Frances M. Richards3,Kevin P. Schifferli2,Courtney L. Andersen2,Emma J. Davies2,Mario Aladren Vicente4,Eiko Ozono1,Aleksandra Markovets2,Lisa Drew2,Vikki Flemington2,Theresa Proia2,Duncan I. Jodrell5,Paul D. Smith2,Simon J. Cook1
1Babraham Institute,2AstraZeneca,3Cancer Research UK,4CRUK Therapeutic Discovery Laboratories,5CRUK

Anti-oestrogen medication use in breast cancer patients and subsequent risk of gastrointestinal cancers: a two country pooled analysis

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Úna McMenamin1,Harlinde De Schutter2,Michael B Cook3,Stuart McIntosh4,Brian T Johnston5,Chris Cardwell1
1Queen's University Belfast, Belfast, UK,2Belgian Cancer Registry, Saint-Josse-ten-Noode, Belgium,3National Cancer Institute, Bethesda, US,4Belfast Health & Social Care Trust, Belfast, UK,5Belfast Health & Social Care Trust

Chronic exposure to the novel PARP inhibitor niraparib (ZEJULA®), in contrast to olaparib, limits the impact of chemotherapy-induced multidrug resistance in ovarian cancer

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Gillian Smith1,Aparajitha Vaidyanathan1,Amber McWhirter1,Lynne Sawers1,Susan Bray1,Kaiming Sun2,Jing Yu Wang2,Michelle Ferguson3
1University of Dundee,2TESARO,3NHS Tayside

Safety and Efficacy of Combined Metronomic Capecitabine with Aromatase Inhibitors for Patients with Newly Diagnosed Metastatic Hormone Positive, HER2 Negative Breast Cancer

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Badr Abdelmaksoud1,Mostafa Toam2
1faculty of medicine, zagazig university,2zagazig university

A predictive model to estimate the probability of EGFR mutation(s) in New Zealand patients with non-squamous NSCLC

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Phyu Aye1,Sandar Tin Tin1,Mark McKeage1,Prashannata Khwaounjoo1,Arier Lee1,Alana Cavadino1,Mark Elwood1
1The University of Auckland

Immune-related hypophysitis: a tertiary referral centre experience

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Ionut-Gabriel Funingana1,Sarah Welsh1,Benjamin Devoy1,Christine Parkinson1,Krishna Chatterjee1,Pippa Corrie1
1Cambridge University Hospitals NHS Foundation Trust

Development of PLGA-Encapsulated Disulfiram as an orphan drug for MALIGNANT mesothelioma

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Sathishkumar Kurusamy1,Vinodh Kannappan2,Andrew Pollard3,Garima Tyagi1,Sathishkumar Kurusamy4,Peng Liu5,Yaohe Wang5,Christopher Ireson6,Weiguang Wang7
1University of Wolverhampton,2Disulfican Ltd.,University of Wolverhampton,3Disulfican Ltd., Wolverhampton,4University of wolverhampton,5Barts Cancer Institute,6Pharmidex Ltd, UK,7Disulfican Ltd, University of Wolverhampton

A Breast Cancer Trainees Research Collaborative Group (BCTRCG) prospective observational study in patients with metastatic breast cancer involving the central nervous system (PRIMROSE)

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Vinton Cheng1,Amanda Fitzpatrick2,Apostolos Konstantis3,Hayley McKenzie4,Amy Kwan5,Ruichong Ma6,Pei Jing Teo7,Harry Haynes8,Shaveta Mehta9,Arunima Mukhapadhyay10,Carlo Palmieri5
1Leeds Teaching Hospitals NHS Trust,2Institute of Cancer Research,3University College London Hospitals NHS Foundation Trust,4University of Southampton,5University of Liverpool,6Oxford University Hospitals NHS Foundation Trust,7University Hospitals Birmingham NHS Foundation Trust,8University of Bristol,9Clatterbridge Cancer Centre NHS Foundation Trust,10University of Glasgow

Bioelectical impedance changes during chemotherapy for early breast cancer: The Cando-2 study

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Stephen Wootton1
1University of Southampton, Southampton, UK

Real world treatment sequencing patterns in secondary breast cancer (SBC): Pathway visualisation using national datasets.

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Ashley Horne1,Maria McMenemy2,Holly Ennis3,Lauren Murdoch3,Grace Ding1,Olga Oikonomidou1,Caroline Michie1,Larry Haywood1,David Cameron1,Christina Lilley1,Peter Hall4,Alison Stillie1,Aisling Hennessy1,Frances Yuille1
1Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK,2Lothian Analytical Services, NHS Lothian, Edinburgh, UK,3Edinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK,4Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK

Palliative radiotherapy to the oesophagus: Less is just as good.

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Shefali Parikh1,Oliver Coen1,Rebecca Goody1,Ganesh Radhakrishna2,Paul Hatfield1,Mohan Hingorani1
1Leeds Cancer Centre,2The Christie, Manchester

Introducing DPD Screening into Clinical Practice: The Sheffield Experience

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Alexander Burnett1,Alice Dewdney2
1Weston Park Hospital,2weston park hospital

Endocrinopathies in patients undergoing treatment with Immune Checkpoint Inhibitors at Royal Cornwall Hospital.

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Dhruv Abhi1
1Royal Cornwall Hospitals NHS Trust

Retrospective analysis of the prevalence of family history of psoriasis in patients who develop rheumatological immune-related adverse events (irAEs)

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Ionut-Gabriel Funingana1,Christine Parkinson1,Sarah Welsh1,Deniz Tafrali2,Pippa Corrie1,Anshuman Malaviya1
1Cambridge University Hospitals NHS Foundation Trust,2Medical University of Graz

Colorectal cancer in patients less than 35 years: 10 year clinical experience from 3 University Hospital Trusts in South East London

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Julien de Naurois1,Matthaios Kapiris1,Ailsa Sita-Lumsden1,Paul Ross1
1Guy's and St Thomas' NHS Foundation Trust

Exploiting the metabolic vulnerabilities imposed by glucocorticoids for glioblastoma treatment

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Maria Francesca Allega1,Victor Villar Cortes2,David Sumpton2,Gillian Mackay2,Saverio Tardito2
1Beatson Institute for Cancer Research,2Cancer Research UK Beatson Institute

Assessment of CCR5/Maraviroc immunotherapy in combination with PD1 and MR-Guided radiotherapy for treatment of pancreatic cancer

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Simone Lanfredini1,Sophie Hughes2,Asmita Thapa2,Fiona Bangs2,Jennifer Morton3,Helen Ferry2,Veerle Kersemans2,Paul Kinchesh2,Sean Smart2,Amily Elliot2,James Thompson2,Mark Hill2,Somnath Mukherjee2,Eric O'Neill2
1Oxford University,2University of Oxford,3University of Glasgow

Best supportive care (BSC) with or without low-dose chemotherapy (chemo) in frail elderly patients with advanced gastroesophageal cancer (aGOAC): The uncertain randomization of the GO2 phase III trial

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Daniel Swinson1,Peter Hall2,Mohan Hingorani3,Zuzani Stokes4,Jo Dent5,Kamalnayan Guptal6,Anirban Chatterjee7,Konstantinos Kamposioras8,Simon Aird Grumett9,Mohammad Khan10,Helen Marshall11,Ruddock Sharon11,Cairns David11,Christine Allmark12,Eszter Katona11,Helen C Howard11,Galina Velikova13,Simon Lord14,Matthew T Seymour15
1St James's University Hospital, Leeds, UK,2University of Edinburgh, Edinburgh.,3St James's University Hospital, Leeds.,4Lincolnshire Hospitals, Lincoln,5Calderdale and Huddersfield Royal Infirmary,6Worcester, United Kingdom,7Shrewsbury & Telford Hospitals, Shrewsbury,8Christie Hospital, Manchester,9Royal Wolverhampton Hospitals, Wolverhampton,10Scarborough Hospital, Scarborough,11CTRU, University of Leeds, Leeds,12NCRI Consumer Forum, London,13University of Leeds, Leeds,14University of Oxford, Oxford,15National Institute for Health Research Clinical Research Network, Leeds, United Kingdom

Polyphenols Enhance the Activity of Alkylating Agents in Leukaemia Cell Lines

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Amani Mahbub1,Dr Nicola Jordan-Mahy2,Prof Christine Le Maitre2,Neil Cross2,Sarah Haywood-Small2
1Umm Al Qura University,2Biomolecular Sciences Research Centre, Sheffield Hallam University